DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment sdt and Pals1

DIOPT Version :9

Sequence 1:	NP_001033835.2	Gene:	sdt / 44861	FlyBaseID:	FBgn0261873	Length:	2020	Species:	Drosophila melanogaster
Sequence 2:	NP_062525.1	Gene:	Pals1 / 56217	MGIID:	1927339	Length:	675	Species:	Mus musculus

Alignment Length:	828	Identity:	329/828 - (39%)
Similarity:	442/828 - (53%)	Gaps:	193/828 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly  1217 HLRVEKDGRLVN---CSPAPQLPDRRAPGNASSGSSGATTHPLQHQQIAQIVEPTLEQLDSIKKY 1278
            |:..|.|..:.|   .|| .:.|..|.......|..|....|::..          .||:.|::.
Mouse     9 HVTEESDSGIKNLDLASP-EEYPKHREMAVDCPGDLGTRMMPVRRS----------AQLERIRQQ 62

  Fly  1279 QEQLRRRREEEERIAQQNEFLRNSLRGSRKLKALQDTATPGKAVAQQQQQATLATQVVGVENEAY 1343
            ||.:|||||||   .::.|.   .|..|.:||.|  ...|.|               .|::|..:
Mouse    63 QEDMRRRREEE---GKKQEL---DLNSSMRLKKL--AQIPPK---------------TGIDNPIF 104

  Fly  1344 LPDE----DQPQ-AEQIDGYGELIAALTRLQNQL----SKSGLSTL-----------AGRVSAAH 1388
            ..:|    :.|. |..|....:|.::|..:|:.|    |:..:|.|           |.::..|.
Mouse   105 DTEEGIVLESPHYAVNILDVEDLFSSLKHIQHTLVDSQSQEDISLLLQLVQNRDFQNAFKIHNAV 169

  Fly  1389 SV-LASASVAHVLAARTAVLQRRRSRVSGPLHHSSLGLQKDIVELLTQSNTAAAIELGNLLTSHE 1452
            :| ::.||....|.|....|.:....|..|:|      ||:..||     ||       ||.:..
Mouse   170 TVHMSKASPPFPLIANVQDLVQEVQTVLKPVH------QKEGQEL-----TA-------LLNAPH 216

  Fly  1453 MEGLLLAHDRIA-NHTDGTPSPTPTPTPAIGAATGSTLSSPVAGPKRNLGMVVPPPVVPPPLAQR 1516
            ::.||||||::| ......|........:||...|.|
Mouse   217 IQALLLAHDKVAEQEMQLEPITDERVYESIGHYGGET---------------------------- 253

  Fly  1517 GAMPLPRGESPPPVPMPPLATMPMSMPVNLPMSACFGTLNDQNDNIRIIQIEKSTE-PLGATVRN 1580
                                                         ::|::|||:.: ||||||||
Mouse   254 ---------------------------------------------VKIVRIEKARDIPLGATVRN 273

  Fly  1581 EGEAVVIGRIVRGGAAEKSGLLHEGDEILEVNGQELRGKTVNEVCALLGAMQGTLTFLIVPAGS- 1644
            |.::|:|.|||:|||||||||||||||:||:||.|:|||.||||..||..|.|||||:::|:..
Mouse   274 EMDSVIISRIVKGGAAEKSGLLHEGDEVLEINGIEIRGKDVNEVFDLLSDMHGTLTFVLIPSQQI 338

  Fly  1645 --PPSVGVMGGTTGSQLAGLGGAHRDTAVLHVRAHFDYDPEDDLYIPCRELGISFQKGDVLHVIS 1707
              ||:                   ::| |:||:|||||||.||.|:||||||:||||||:|||||
Mouse   339 KPPPA-------------------KET-VIHVKAHFDYDPSDDPYVPCRELGLSFQKGDILHVIS 383

  Fly  1708 REDPNWWQAYREGEED-QTLAGLIPSQSFQHQRETMKLAIAEEAGLARSRGKDGSGSKGATLLCA 1771
            :||||||||||||:|| |.||||:|.:|||.|||.||..|.|          |....|...|.||
Mouse   384 QEDPNWWQAYREGDEDNQPLAGLVPGKSFQQQREAMKQTIEE----------DKEPEKSGKLWCA 438

  Fly  1772 RKGRKKKKKASSEAGYPLYATTAPDETDPEEILTYEEVALYYPRATHKRPIVLIGPPNIGRHELR 1836
            :|.:||:||.       ||.....|:.|.||||||||::||:..|..||||:||||.|.|::|||
Mouse   439 KKNKKKRKKV-------LYNANKNDDYDNEEILTYEEMSLYHQPANRKRPIILIGPQNCGQNELR 496

  Fly  1837 QRLM-ADSERFSAAVPHTSRARREGEVPGVDYHFITRQAFEADILARRFVEHGEYEKAYYGTSLE 1900
            |||| .:.:||::|||||:|.||:.||.|.||||::||||||||.|.:|:||||:||..||||::
Mouse   497 QRLMNKEKDRFASAVPHTTRNRRDHEVAGRDYHFVSRQAFEADIAAGKFIEHGEFEKNLYGTSID 561

  Fly  1901 AIRTVVASGKICVLNLHPQSLKLLRASDLKPYVVLVAPPSLDKLRQKKLRNGEPFKEEELKDIIA 1965
            ::|.|:.|||||:|:|..||||.||.||||||::.:||||.::||....:.|:..|.|||::||.
Mouse   562 SVRQVINSGKICLLSLRTQSLKTLRNSDLKPYIIFIAPPSQERLRALLAKEGKNPKPEELREIIE 626

  Fly  1966 TARDMEARWGHLFDMIIINNDTERAYHQLLAEINSLEREPQWVPAQWV 2013
            ..|:||...||.||..|:|:|.::||.:||..||.|:.||||||:.|:
Mouse   627 KTREMEQNNGHYFDTAIVNSDLDKAYQELLRLINKLDTEPQWVPSTWL 674

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
sdt	NP_001033835.2	PDZ_signaling	<54..102	CDD:238492
		L27	1423..1466	CDD:295425	15/43 (35%)
		PDZ_signaling	1562..1640	CDD:238492	53/78 (68%)
		SH3_MPP5	1673..1734	CDD:212969	49/61 (80%)
		Guanylate_kin	1820..1994	CDD:279019	99/174 (57%)
		GuKc	1831..2002	CDD:214504	95/171 (56%)
Pals1	NP_062525.1	Required for the correct localization of PALS1 and PATJ at cell-cell contacts and the normal formation of tight junctions and adherens junctions. /evidence=ECO:0000269\|PubMed:17182851	1..345		131/479 (27%)
		Interaction with PARD6B. /evidence=ECO:0000269\|PubMed:15140881	21..140		37/152 (24%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	51..79		12/40 (30%)
		L27_N	123..170	CDD:370269	9/46 (20%)
		Interaction with LIN7C. /evidence=ECO:0000269\|PubMed:10753959	181..243		22/79 (28%)
		L27	189..237	CDD:197794	19/65 (29%)
		PDZ_signaling	254..333	CDD:238492	53/78 (68%)
		SH3_MPP5	349..411	CDD:212969	49/61 (80%)
		GuKc	491..661	CDD:214504	94/169 (56%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167841512
Domainoid	1	1.000	213	1.000	Domainoid score	I2754
eggNOG	1	0.900	-	-		E1_COG0194
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H9512
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S2106
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D245552at33208
OrthoFinder	1	1.000	-	-		FOG0000824
OrthoInspector	1	1.000	-	-		oto94004
orthoMCL	1	0.900	-	-		OOG6_107065
Panther	1	1.100	-	-	LDO	PTHR23122
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3662
SonicParanoid	1	1.000	-	-		X4595
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	14	13.690