DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment sdt and PALS2

DIOPT Version :9

Sequence 1:	NP_001033835.2	Gene:	sdt / 44861	FlyBaseID:	FBgn0261873	Length:	2020	Species:	Drosophila melanogaster
Sequence 2:	NP_001289966.1	Gene:	PALS2 / 51678	HGNCID:	18167	Length:	540	Species:	Homo sapiens

Alignment Length:	703	Identity:	221/703 - (31%)
Similarity:	316/703 - (44%)	Gaps:	193/703 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly  1338 VENEAYLPDEDQPQAEQIDGYGELIAALTRLQNQLSKSGLSTLAGRVSAAHSVLASASVAHVLAA 1402
            :||...||  ....||:||    ||.....::|.:.||        ::.||..|..:.:..|
Human     5 LENLTELP--SSTGAEEID----LIFLKGIMENPIVKS--------LAKAHERLEDSKLEAV--- 52

  Fly  1403 RTAVLQRRRSRVSGPLHHSSLGLQKDIVELLT-----QSNTAAAIELGNLLTSHEMEGLLLAHDR 1462
                            ..::|.|..:|:|.:|     ..|.|   ||..:|.....:.||.|||.
Human    53 ----------------SDNNLELVNEILEDITPLINVDENVA---ELVGILKEPHFQSLLEAHDI 98

  Fly  1463 IANHTDGTPSPTPTPTPAIGAATGSTLSSPVAGPKRNLGMVVPPPVVPPPLAQRGAMPLPRGESP 1527
            :|:                     ....||.:.|:.|
Human    99 VAS---------------------KCYDSPPSSPEMN---------------------------- 114

  Fly  1528 PPVPMPPLATMPMSMPVN---LPMSACFGTLNDQNDNIRIIQIEK-STEPLGATVRNEGEAVVIG 1588
                         :..:|   ||:           |.|||:.|.| :.||||.|.|.|...:||.
Human   115 -------------NSSINNQLLPV-----------DAIRILGIHKRAGEPLGVTFRVENNDLVIA 155

  Fly  1589 RIVRGGAAEKSGLLHEGDEILEVNGQELRGKTVNEVCALLGAMQGTLTFLIVPAGSPPSVGVMGG 1653
            ||:.||..::.||||.||.|.||||.|: |....|:..||..:.|::|..|:|
Human   156 RILHGGMIDRQGLLHVGDIIKEVNGHEV-GNNPKELQELLKNISGSVTLKILP------------ 207

  Fly  1654 TTGSQLAGLGGAHRDTAV---LHVRAHFDYDPEDDLYIPCRELGISFQKGDVLHVISREDPNWWQ 1715
                       ::|||..   :.|:.||||:|.:|..|||:|.|:.|.||::|.:::||||||||
Human   208 -----------SYRDTITPQQVFVKCHFDYNPYNDNLIPCKEAGLKFSKGEILQIVNREDPNWWQ 261

  Fly  1716 A--YREGEEDQTLAGLIPSQSFQHQRETMKLAIAEEAGLARSRGKDGSGSKGATLLCARKGRKKK 1778
            |  .:||..    |||||||..:.:|:...           .|..|.||.     .|.....|||
Human   262 ASHVKEGGS----AGLIPSQFLEEKRKAFV-----------RRDWDNSGP-----FCGTISSKKK 306

  Fly  1779 KKASSEAGYPLYATTAPDETDPEEILTYEEVALYYPRATHKRPIVLIGPPNIGRHELRQR-LMAD 1842
            ||.       :|.||...|.|..||..|||||...|  ..::.:||||...:||..|:.| ::.:
Human   307 KKM-------MYLTTRNAEFDRHEIQIYEEVAKMPP--FQRKTLVLIGAQGVGRRSLKNRFIVLN 362

  Fly  1843 SERFSAAVPHTSRARREGEVPGVDYHFITRQAFEADILARRFVEHGEYEKAYYGTSLEAIRTVVA 1907
            ..||...||.|||..||.|..|..|.|::|...||||.|.:::||||||...|||.:::|..||.
Human   363 PTRFGTTVPFTSRKPREDEKDGQAYKFVSRSEMEADIKAGKYLEHGEYEGNLYGTKIDSILEVVQ 427

  Fly  1908 SGKICVLNLHPQSLKLLRASDLKPYVVLVAPPSLDKLR-----------QKKLRNGEPFKEEELK 1961
            :|:.|:|:::||:||:||.|:..||||.:|.|.|:.||           ..||     ..:.:||
Human   428 TGRTCILDVNPQALKVLRTSEFMPYVVFIAAPELETLRAMHKAVVDAGITTKL-----LTDSDLK 487

  Fly  1962 DIIATARDMEARWGHLFDMIIINNDTERAYHQLLAEINSLEREPQWVPAQWVH 2014
            ..:..:..::..:.|.||:||||::.::|:.:|...|..|..||||||..||:
Human   488 KTVDESARIQRAYNHYFDLIIINDNLDKAFEKLQTAIEKLRMEPQWVPISWVY 540

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
sdt	NP_001033835.2	PDZ_signaling	<54..102	CDD:238492
		L27	1423..1466	CDD:295425	16/47 (34%)
		PDZ_signaling	1562..1640	CDD:238492	36/78 (46%)
		SH3_MPP5	1673..1734	CDD:212969	33/62 (53%)
		Guanylate_kin	1820..1994	CDD:279019	70/185 (38%)
		GuKc	1831..2002	CDD:214504	68/182 (37%)
PALS2	NP_001289966.1	L27	2..55	CDD:197794	17/82 (21%)
		L27	57..108	CDD:397114	17/74 (23%)
		PDZ_signaling	133..206	CDD:238492	33/73 (45%)
		SH3_MPP6	219..279	CDD:212971	34/63 (54%)
		Guanylate_kin	337..527	CDD:395500	72/194 (37%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0194
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810