DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment sdt and Mpp2

DIOPT Version :9

Sequence 1:	NP_001033835.2	Gene:	sdt / 44861	FlyBaseID:	FBgn0261873	Length:	2020	Species:	Drosophila melanogaster
Sequence 2:	NP_001343253.1	Gene:	Mpp2 / 50997	MGIID:	1858257	Length:	569	Species:	Mus musculus

Alignment Length:	691	Identity:	219/691 - (31%)
Similarity:	316/691 - (45%)	Gaps:	149/691 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly  1336 VGVENEAYLPDEDQPQAEQIDGYGELIAALTRLQNQLSKSGLSTLAGRVSAAHSVLASASVAHVL 1400
            :|...||.|..|...|.  :|..|.       |.|....:.|..:..|......::.|.:.||..
Mouse    16 LGSSEEAELRREAMQQV--LDNLGS-------LPNATGAAELDLIFLRGIMESPIVRSLAKAHER 71

  Fly  1401 AART---AVLQRRRSRVSGPLHHSSLGLQKDIVELLTQSNTAAAIELGNLLTSHEMEGLLLAHDR 1462
            ...|   ||.......|...|        :|:.||..||:|||  ||..:|.....:.||..||.
Mouse    72 LEETKLEAVRDNNLELVQEIL--------RDLAELAEQSSTAA--ELARILQEPHFQSLLETHDS 126

  Fly  1463 IANHTDGTPSPTPTPTPAIGAATGSTLSSPVAGPKRNLGMVVPPPVVPPPLAQRGAMPLPRGESP 1527
            :|:.|..||.|:|...|        |.|:.
Mouse   127 VASKTYETPPPSPGLDP--------TFSNQ----------------------------------- 148

  Fly  1528 PPVPMPPLATMPMSMPVNLPMSACFGTLNDQNDNIRIIQIEKST-EPLGATVRNEGEAVVIGRIV 1591
               |:||                         |.:|::.|.|:. |.||.|.|.||..:||.||:
Mouse   149 ---PVPP-------------------------DAVRMVGIRKTAGEHLGVTFRVEGGELVIARIL 185

  Fly  1592 RGGAAEKSGLLHEGDEILEVNGQELRGKTVNEVCALLGAMQGTLTFLIVPAGSPPSVGVMGGTTG 1656
            .||...:.||||.||.|.|||||.: |.....:..||.:..|::...|:|:...|
Mouse   186 HGGMVAQQGLLHVGDIIKEVNGQPV-GSDPRALQELLRSASGSVILKILPSYQEP---------- 239

  Fly  1657 SQLAGLGGAHRDTAVLHVRAHFDYDPEDDLYIPCRELGISFQKGDVLHVISREDPNWWQA-YREG 1720
                     |....|. |:.||||||..|...||:|.|:.|..||:|.:::::|.||||| :.||
Mouse   240 ---------HLPRQVF-VKCHFDYDPARDSLSPCKEAGLRFNAGDLLQIVNQDDANWWQACHVEG 294

  Fly  1721 EEDQTLAGLIPSQSFQHQRETMKLAIAEEAGLARSRGKDGSGSKGATLLCARKGRKKKKKASSEA 1785
            ..    |||||||..:.:|   |..:..:..|..:.|          .||.....||||:.
Mouse   295 GS----AGLIPSQLLEEKR---KAFVKRDLELTPTSG----------TLCGSLSGKKKKRM---- 338

  Fly  1786 GYPLYATTAPDETDPEEILTYEEVALYYPRATHKRPIVLIGPPNIGRHELRQRLMA-DSERFSAA 1849
               :|.||...|.|..|:|.|||||...|  ..::.:||||...:||..|:.:|:. |.:|:...
Mouse   339 ---MYLTTKNAEFDRHELLIYEEVARMPP--FRRKTLVLIGAQGVGRRSLKNKLILWDPDRYGTT 398

  Fly  1850 VPHTSRARREGEVPGVDYHFITRQAFEADILARRFVEHGEYEKAYYGTSLEAIRTVVASGKICVL 1914
            ||:|||..::.|..|..|.|::|...||||.|.|::||||||...|||.:::||.||||||:|||
Mouse   399 VPYTSRRPKDSEREGQGYSFVSRGEMEADIRAGRYLEHGEYEGNLYGTRIDSIRGVVASGKVCVL 463

  Fly  1915 NLHPQSLKLLRASDLKPYVVLVAPPSLDKLR---QKKLRNGEPFK---EEELKDIIATARDMEAR 1973
            :::||::|:||.::..||||.:..|..:.||   :..|.:|...|   |.:|:..:..:..::..
Mouse   464 DVNPQAVKVLRTAEFVPYVVFIEAPDYETLRAMNRAALESGVSTKQLTEADLRRTVEESSRIQRG 528

  Fly  1974 WGHLFDMIIINNDTERAYHQLLAEINSLEREPQWVPAQWVH 2014
            :||.||:.::|::.||.:.:|...:..|..||||||..||:
Mouse   529 YGHYFDLSLVNSNLERTFRELQTAMEKLRTEPQWVPVSWVY 569

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
sdt	NP_001033835.2	PDZ_signaling	<54..102	CDD:238492
		L27	1423..1466	CDD:295425	16/42 (38%)
		PDZ_signaling	1562..1640	CDD:238492	32/78 (41%)
		SH3_MPP5	1673..1734	CDD:212969	30/61 (49%)
		Guanylate_kin	1820..1994	CDD:279019	70/180 (39%)
		GuKc	1831..2002	CDD:214504	67/177 (38%)
Mpp2	NP_001343253.1	L27	30..83	CDD:197794	13/61 (21%)
		L27	85..136	CDD:308467	20/60 (33%)
		PDZ_signaling	155..233	CDD:238492	32/78 (41%)
		SH3_MPP2	246..304	CDD:212970	30/62 (48%)
		GuKc	376..557	CDD:214504	67/180 (37%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0194
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810