Protein Alignment sdt and CASK

DIOPT Version :10

• Sequence 1: NP_001033835.2
• Gene: sdt / 44861
• FlyBaseID: FBgn0261873
• Length: 2020
• Species: Drosophila melanogaster
• Sequence 2: XP_061499758.1
• Gene: CASK / 4577273
• VectorBaseID: AGAMI1_013356
• Length: 955
• Species: Anopheles gambiae
• Alignment Length: 981
• Identity: 260/981 - (26%)
• Similarity: 394/981 - (40%)
• Gaps: 287/981 - (29%)

  Fly  1122 EMVKTTPRYPP-PAHLSSRGSLL----SNGSASTAHTTLSSMGVAPSPVTATAAAAASASAACAT 1181
            :.|:|..|..| .:.||.||.|.    |.|.....|.      :||..|
Mosquito   174 DSVETHERLDPHRSFLSPRGKLYLKTDSEGRVGCPHY------MAPEVV---------------- 216

  Fly  1182 TAVAAAAVSGVADGDARRVADELNGNAKPVPPPRD------HLRVEKDGRLVNCSPAPQLPDRRA 1240
                           ||||..:          |.|      .|.|...|||.......:|.|..|
Mosquito   217 ---------------ARRVYGK----------PCDVWGAGVMLHVLLSGRLPFHGSGKRLQDAIA 256

  Fly  1241 PGNASSG-------SSGA--------TTHPLQHQQIAQIVE-PTLEQLDSIKKYQ-----EQLRR 1284
            .|..:..       ||.|        ..:|:....|.:::: |.:...|.:::..     |:|:|
Mosquito   257 RGRVTLDTPEWKHISSNAKDLVLKMLAPNPISRPTITEVLDHPWIRDRDKLQRIHLGDTVEELKR 321

  Fly  1285 RREEEERIAQQNEFLRNSLRGSRKLKALQDTATPGKAV-----AQQQQQATLATQVVGVENEA-- 1342
                              ....|||||...|...|.|:     |.....|      :|..:|:
Mosquito   322 ------------------YNARRKLKAAVQTVAGGVAMDPLCCADTDSMA------IGAASESLN 362

  Fly  1343 -YLPDEDQPQAEQ--IDGYGELIAALTRLQNQLSKSGLSTLAG--RVSAAHSVLASASVAHVLAA 1402
             :..:|...:|.|  :|...::||    ||:  :......|||  |....|.:|
Mosquito   363 EWADEEAGLEAIQKILDSLDDIIA----LQD--ANCDPDMLAGMLRDVKLHELL----------- 410

  Fly  1403 RTAVLQRRRSRVSGPLH---HSSLGLQKDIVELLTQSNTAA------AIELGNLLTSHEMEGLLL 1458
              .:..|..|.|..|..   ..::...:|.::::  |:||.      ..||.|||.|..::.||.
Mosquito   411 --QLFDRISSSVINPSRAPPGDAISRCRDAIDVI--SSTAGHKYVREKSELINLLGSPHIQALLH 471

  Fly  1459 AHDRIANHTDGTPSPTPTPTPAIGAATGSTLSSPVAGPKRNLGMVVPPPVVPPPLAQRGAMPLPR 1523
            .||.:|....|..:..                                 |.|||:|     |...
Mosquito   472 THDVVAREVYGEEALR---------------------------------VTPPPIA-----PYLN 498

  Fly  1524 GESPPPVPMPPLATMPMSMPVNLPMSACFGTLNDQNDN-----------IRIIQIEKST-EPLGA 1576
            |.                              ||:.||           :|::|.:|:| ||:|.
Mosquito   499 GG------------------------------NDELDNGDAGELQHVTRVRLVQFQKNTDEPMGI 533

  Fly  1577 TVR-NEGEAVVIGRIVRGGAAEKSGLLHEGDEILEVNGQELRGKTVNEVCALLGAMQGTLTFLIV 1640
            |:: .|....::.||:.||...:...||.||||.|:|||.::.:||:::..||...:|::||.||
Mosquito   534 TLKMTEDGRCIVARIMHGGMIHRQATLHVGDEIREINGQPVQHQTVSQLQRLLRDARGSVTFKIV 598

  Fly  1641 PA--GSPPSVGVMGGTTGSQLAGLGGAHRDTAVLHVRAHFDYDPEDDLYIPCRELGISFQKGDVL 1703
            |:  .:||.|         :|..:..|......:.|||.|||||.||..|||.:.||:|:.||:|
Mosquito   599 PSYRSAPPPV---------ELFRIRPAPVLVDQIFVRAQFDYDPLDDELIPCAQAGIAFRVGDIL 654

  Fly  1704 HVISREDPNWWQAYREGEEDQTLAGLIPSQSFQHQRETMKLAIAE-----EAGLARSRGKDGSGS 1763
            .:||::|.:||||..:.....  ||||||...|..|...:.|...     |||...|  ....|.
Mosquito   655 QIISKDDHHWWQARHDAAGGS--AGLIPSPELQEWRIACQSADKSHKEQGEAGPGCS--AQAEGC 715

  Fly  1764 KGATLL-CARKGRKKKKKASSEAGYPLYATTAPDETDPEEILTYEEVALYYP---RATHKRPIVL 1824
            :|.|:: |:...||||:....      |........|..:::||||| :..|   .|..:|.:||
Mosquito   716 EGPTVVNCSIFSRKKKQCRDK------YLAKHNAVFDQLDLVTYEEV-VKVPIGDPAFQRRTLVL 773

  Fly  1825 IGPPNIGRHELRQRLMAD-SERFSAAVPHTSRARREGEVPGVDYHFITRQAFEADILARRFVEHG 1888
            :|...:||..::..|:|. .::::..:|||:|..|..|..|..|:||:.....|||.|..::|:|
Mosquito   774 LGAHGVGRRHIKNTLIAKYPDKYAYPIPHTTRPPRPDEENGRSYYFISHDEMMADISANEYLEYG 838

  Fly  1889 EYEKAYYGTSLEAIRTVVASGKICVLNLHPQSLKLLRASDLKPYVVLVAPP----------SLDK 1943
            .:|.|.|||.||.||.:.|.||:.:|::.||:||:||.::..||||.:|.|          ||::
Mosquito   839 THEDAMYGTKLETIRRIHADGKMAILDVEPQALKILRTAEFTPYVVFIAAPLLQNIADYDGSLER 903

  Fly  1944 LRQKKLRNGEPFKEEELKDIIATARDMEARWGHLFDMIIINNDTERAYHQLLAEINSLEREPQWV 2008
            |.          ||.::         :...:||.||:.|:|||.......|...|:.:....|||
Mosquito   904 LA----------KESDM---------LRQAYGHFFDLTIVNNDIGETIATLENAIDKVHSTAQWV 949

  Fly  2009 PAQWVH 2014
            |..|::
Mosquito   950 PVSWLY 955

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
sdt	NP_001033835.2	PDZ	<54..100	CDD:214570
		PDZ_MPP5-like	1563..1641	CDD:467259	31/79 (39%)
		SH3_MPP5	1673..1734	CDD:212969	32/60 (53%)
		GuKc	1831..2002	CDD:214504	60/181 (33%)
CASK	XP_061499758.1	None