Protein Alignment sdt and MPP2

DIOPT Version :9

• Sequence 1: NP_001033835.2
• Gene: sdt / 44861
• FlyBaseID: FBgn0261873
• Length: 2020
• Species: Drosophila melanogaster
• Sequence 2: XP_011523129.2
• Gene: MPP2 / 4355
• HGNCID: 7220
• Length: 630
• Species: Homo sapiens
• Alignment Length: 597
• Identity: 197/597 - (32%)
• Similarity: 290/597 - (48%)
• Gaps: 129/597 - (21%)

  Fly  1427 KDIVELLTQSNTAAAIELGNLLTSHEMEGLLLAHDRIANHTDGTPSPTPTPTPAIGAATGSTLSS 1491
            :|:.:|..||:|||  ||.::|.....:.||..||.:|:.|..||.|:|...|        |.|:
Human   154 RDLAQLAEQSSTAA--ELAHILQEPHFQSLLETHDSVASKTYETPPPSPGLDP--------TFSN 208

  Fly  1492 PVAGPKRNLGMVVPPPVVPPPLAQRGAMPLPRGESPPPVPMPPLATMPMSMPVNLPMSACFGTLN 1556
            .                                      |:||
Human   209 Q--------------------------------------PVPP---------------------- 213

  Fly  1557 DQNDNIRIIQIEKST-EPLGATVRNEGEAVVIGRIVRGGAAEKSGLLHEGDEILEVNGQELRGKT 1620
               |.:|::.|.|:. |.||.|.|.||..:||.||:.||...:.||||.||.|.|||||.: |..
Human   214 ---DAVRMVGIRKTAGEHLGVTFRVEGGELVIARILHGGMVAQQGLLHVGDIIKEVNGQPV-GSD 274

  Fly  1621 VNEVCALLGAMQGTLTFLIVPAGSPPSVGVMGGTTGSQLAGLGGAHRDTAVLHVRAHFDYDPEDD 1685
            ...:..||....|::...|:|:...|                   |....|. |:.||||||..|
Human   275 PRALQELLRNASGSVILKILPSYQEP-------------------HLPRQVF-VKCHFDYDPARD 319

  Fly  1686 LYIPCRELGISFQKGDVLHVISREDPNWWQA-YREGEEDQTLAGLIPSQSFQHQRETMKLAIAEE 1749
            ..|||:|.|:.|..||:|.:::::|.||||| :.||..    |||||||..:.:|   |..:..:
Human   320 SLIPCKEAGLRFNAGDLLQIVNQDDANWWQACHVEGGS----AGLIPSQLLEEKR---KAFVKRD 377

  Fly  1750 AGLARSRGKDGSGSKGATLLCARKGRKKKKKASSEAGYPLYATTAPDETDPEEILTYEEVALYYP 1814
            ..|..:.|          .||.....||||:.       :|.||...|.|..|:|.|||||...|
Human   378 LELTPNSG----------TLCGSLSGKKKKRM-------MYLTTKNAEFDRHELLIYEEVARMPP 425

  Fly  1815 RATHKRPIVLIGPPNIGRHELRQRL-MADSERFSAAVPHTSRARREGEVPGVDYHFITRQAFEAD 1878
              ..::.:||||...:||..|:.:| |.|.:|:...||:|||..::.|..|..|.|::|...|||
Human   426 --FRRKTLVLIGAQGVGRRSLKNKLIMWDPDRYGTTVPYTSRRPKDSEREGQGYSFVSRGEMEAD 488

  Fly  1879 ILARRFVEHGEYEKAYYGTSLEAIRTVVASGKICVLNLHPQSLKLLRASDLKPYVVLVAPPSLDK 1943
            :.|.|::||||||...|||.:::||.|||:||:|||:::||::|:||.::..||||.:..|..:.
Human   489 VRAGRYLEHGEYEGNLYGTRIDSIRGVVAAGKVCVLDVNPQAVKVLRTAEFVPYVVFIEAPDFET 553

  Fly  1944 LR---QKKLRNG---EPFKEEELKDIIATARDMEARWGHLFDMIIINNDTERAYHQLLAEINSLE 2002
            ||   :..|.:|   :...|.:|:..:..:..::..:||.||:.::|::.||.:.:|...:..|.
Human   554 LRAMNRAALESGISTKQLTEADLRRTVEESSRIQRGYGHYFDLCLVNSNLERTFRELQTAMEKLR 618

  Fly  2003 REPQWVPAQWVH 2014
            .||||||..||:
Human   619 TEPQWVPVSWVY 630

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
sdt	NP_001033835.2	PDZ_signaling	<54..102	CDD:238492
		L27	1423..1466	CDD:295425	15/38 (39%)
		PDZ_signaling	1562..1640	CDD:238492	32/78 (41%)
		SH3_MPP5	1673..1734	CDD:212969	31/61 (51%)
		Guanylate_kin	1820..1994	CDD:279019	68/180 (38%)
		GuKc	1831..2002	CDD:214504	65/177 (37%)
MPP2	XP_011523129.2	None

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0194
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810