DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment sdt and MPP1

DIOPT Version :9

Sequence 1:	NP_001033835.2	Gene:	sdt / 44861	FlyBaseID:	FBgn0261873	Length:	2020	Species:	Drosophila melanogaster
Sequence 2:	NP_002427.1	Gene:	MPP1 / 4354	HGNCID:	7219	Length:	466	Species:	Homo sapiens

Alignment Length:	494	Identity:	148/494 - (29%)
Similarity:	245/494 - (49%)	Gaps:	63/494 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly  1526 SPPPVPMPPLATMPMSMPVN-LPMSACFGTLNDQN-DNIRIIQIEKST-EPLGATVR-NEGEAVV 1586
            |.|.....||.|:...|..| .|.......:..|. ..:|:||.||.| ||:|.|:: ||.::..
Human    31 SRPEAVSHPLNTVTEDMYTNGSPAPGSPAQVKGQEVRKVRLIQFEKVTEEPMGITLKLNEKQSCT 95

  Fly  1587 IGRIVRGGAAEKSGLLHEGDEILEVNGQELRGKTVNEVCALLGAMQGTLTFLIVPAGSPPSVGVM 1651
            :.||:.||...:.|.||.||||||:||..:...:|:::...:...:|.::..::|
Human    96 VARILHGGMIHRQGSLHVGDEILEINGTNVTNHSVDQLQKAMKETKGMISLKVIP---------- 150

  Fly  1652 GGTTGSQLAGLGGAHRDTAVLHVRAHFDYDPEDDLYIPCRELGISFQKGDVLHVISREDPNWWQA 1716
              ...|:|..|        .:.:||.|||||:.|..|||:|.|:.|..||::.:|:::|.||||.
Human   151 --NQQSRLPAL--------QMFMRAQFDYDPKKDNLIPCKEAGLKFATGDIIQIINKDDSNWWQG 205

  Fly  1717 YREGEEDQTLAGLIPSQSFQHQRETMKLAIAEEAGLARSRGKDGSGSKGATLLCARKGRKKKKKA 1781
            ..||...:: ||||||...|..|         .|.:|:|...:...       |:..|:|||.|.
Human   206 RVEGSSKES-AGLIPSPELQEWR---------VASMAQSAPSEAPS-------CSPFGKKKKYKD 253

  Fly  1782 SSEAGYPLYATTAPDETDPEEILTYEEVALYYPRATHKRPIVLIGPPNIGRHELRQRLMADS-ER 1845
            .       |........|..::::|||| :..| |..::.:||||...:||..::..|::.: |:
Human   254 K-------YLAKHSSIFDQLDVVSYEEV-VRLP-AFKRKTLVLIGASGVGRSHIKNALLSQNPEK 309

  Fly  1846 FSAAVPHTSRARREGEVPGVDYHFITRQAFEADILARRFVEHGEYEKAYYGTSLEAIRTVVASGK 1910
            |...||:|:|..|:.|..|.:||||:.:....:|.|..|:|.|.|:...:||..|.:..:....|
Human   310 FVYPVPYTTRPPRKSEEDGKEYHFISTEEMTRNISANEFLEFGSYQGNMFGTKFETVHQIHKQNK 374

  Fly  1911 ICVLNLHPQSLKLLRASDLKPYVVLVAPPSLDKLRQKKLRNGEPFKEEELKDIIATARDMEARWG 1975
            |.:|::.||:||::|.::|.|::|.:||            ..:..:.|.|:.:...:..:.:::.
Human   375 IAILDIEPQTLKIVRTAELSPFIVFIAP------------TDQGTQTEALQQLQKDSEAIRSQYA 427

  Fly  1976 HLFDMIIINNDTERAYHQLLAEINSLEREPQWVPAQWVH 2014
            |.||:.::||..:....:|....:.....|||||..||:
Human   428 HYFDLSLVNNGVDETLKKLQEAFDQACSSPQWVPVSWVY 466

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
sdt	NP_001033835.2	PDZ_signaling	<54..102	CDD:238492
		L27	1423..1466	CDD:295425
		PDZ_signaling	1562..1640	CDD:238492	29/79 (37%)
		SH3_MPP5	1673..1734	CDD:212969	30/60 (50%)
		Guanylate_kin	1820..1994	CDD:279019	49/174 (28%)
		GuKc	1831..2002	CDD:214504	46/171 (27%)
MPP1	NP_002427.1	PDZ	71..149	CDD:366185	28/77 (36%)
		SH3_MPP1	162..223	CDD:213013	30/61 (49%)
		Interaction with PALS1. /evidence=ECO:0000269\|PubMed:17584769	268..466		62/211 (29%)
		Guanylate_kin	281..453	CDD:366206	50/183 (27%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0194
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810