DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment sdt and CASK

DIOPT Version :9

Sequence 1:	NP_001033835.2	Gene:	sdt / 44861	FlyBaseID:	FBgn0261873	Length:	2020	Species:	Drosophila melanogaster
Sequence 2:	NP_001262811.1	Gene:	CASK / 42567	FlyBaseID:	FBgn0013759	Length:	929	Species:	Drosophila melanogaster

Alignment Length:	912	Identity:	228/912 - (25%)
Similarity:	361/912 - (39%)	Gaps:	231/912 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly  1186 AAAVSGVADGDARRVADELNGNAKPVPPPRDHLRVEKDGRLVNCS--PAPQLPDRRAPGNASS-G 1247
            |.|:....|..|   ..:|.|....:..|.....:|..|| |.|.  .||::..||..|.... .
  Fly   145 ACALLATVDNSA---PVKLGGFGSAIQLPGTRETIETHGR-VGCPHYMAPEVVTRRLYGKGCDVW 205

  Fly  1248 SSGATTHPLQHQQIAQIVEPTLEQLDSIKKYQEQLRRRREEEE----------------RIAQQN 1296
            .:|...|.|        :...|..|.|..:.|:.:.|.|...|                ::...|
  Fly   206 GAGVMLHVL--------LSGRLPFLGSGVRLQQSVARGRLSFEAPEWKSISANAKDLVMKMLAAN 262

  Fly  1297 EFLRNS---------LRGSRKLKA--LQDTATPGKAVAQQQQQATLATQVVGVEN--EAYLPDED 1348
            ...|.|         :|...||:.  |.||....|....:::.......:.|..|  ..|..|.|
  Fly   263 PHHRLSITEVLDHPWIRDRDKLQRTHLADTVEELKRYNARRKLKGAVQAIAGGTNMDPLYATDAD 327

  Fly  1349 QPQAEQIDGYGELIAALTRLQNQLSKSGLSTLAGRVSAAHSVLASASVAHVLA------------ 1401
            .|.....|.:.:..|.:..:|             |:......:.|...|||.|
  Fly   328 MPITGATDEWADEEAGIEAVQ-------------RILDCLDDIYSLQDAHVDADVLRDMLRDNRL 379

  Fly  1402 ----------ARTAVLQRRRSRVSGPLHHSSLGLQKDIVELLTQSNTAAAI-------ELGNLLT 1449
                      |.|.|....|:..:     .::|..:|::|.|:.::...::       ||..||.
  Fly   380 HQFLQLFDRIAATVVTSNGRAPAA-----EAVGRCRDVLEQLSSTSGGNSLGGKYAKEELMRLLA 439

  Fly  1450 SHEMEGLLLAHDRIANHTDGTPSPTPTPTPAIGAATGSTLSSPVAGPKRNLGMVVPPPVVPPPLA 1514
            :..|:.||.:||.:|....|..:...||.|.:....|..|.:...|..:::
  Fly   440 APHMQALLHSHDVVARDVYGEEALRVTPPPMVPYLNGDELDNVEGGELQHV-------------- 490

  Fly  1515 QRGAMPLPRGESPPPVPMPPLATMPMSMPVNLPMSACFGTLNDQNDNIRIIQIEKST-EPLGATV 1578
                                                         ..:|::|.:|:| ||:|.|:
  Fly   491 ---------------------------------------------TRVRLVQFQKNTDEPMGITL 510

  Fly  1579 R-NEGEAVVIGRIVRGGAAEKSGLLHEGDEILEVNGQELRGKTVNEVCALLGAMQGTLTFLIVPA 1642
            : .|....::.||:.||...:...||.||||.|:|||.::.::|.::..:|...:|::||.|||:
  Fly   511 KMTEDGRCIVARIMHGGMIHRQATLHVGDEIREINGQPVQHQSVGQLQRMLREARGSVTFKIVPS 575

  Fly  1643 --GSPPSVGVMGGTTGSQLAGLGGAHRDTAVLHVRAHFDYDPEDDLYIPCRELGISFQKGDVLHV 1705
              .:||...:.                      |||.|||:|.||..|||.:.|||||.||:|.:
  Fly   576 YRSAPPPCEIF----------------------VRAQFDYNPLDDELIPCAQAGISFQVGDILQI 618

  Fly  1706 ISREDPNWWQAYREGEEDQTL---AGLIPSQSFQHQR---ETMKLAIAEEAGLARSRGKDGSGSK 1764
            ||::|.:||||..:     |:   ||||||...|..|   :|:.....|:..
  Fly   619 ISKDDHHWWQARLD-----TVGGSAGLIPSPELQEWRIACQTVDKTKQEQVN------------- 665

  Fly  1765 GATLLCARKGRKKKKKASSEAGYPLYATTAPDETDPEEILTYEEVALY------YPRATHKRPIV 1823
                 |:..|||||:....      |........|..:::|||||...      :.|.|    :|
  Fly   666 -----CSIFGRKKKQCRDK------YLAKHNAIFDTLDVVTYEEVVKVPVGDPNFQRKT----LV 715

  Fly  1824 LIGPPNIGRHELRQRLMAD-SERFSAAVPHTSRARREGEVPGVDYHFITRQAFEADILARRFVEH 1887
            |:|...:||..::..|::. .::::..:|||:|..:..|..|..|:|::.....|||.|..::|:
  Fly   716 LLGAHGVGRRHIKNTLISKYPDKYAYPIPHTTRPAKPEEENGRSYYFVSHDEMMADIGANEYLEY 780

  Fly  1888 GEYEKAYYGTSLEAIRTVVASGKICVLNLHPQSLKLLRASDLKPYVVLVAPPSLDKLRQKKLRNG 1952
            |.:|.|.|||.|:.||.:...||:.:|::.||:||:||.::..||||.:|.|||..:........
  Fly   781 GTHEDAMYGTKLDTIRRIHTEGKMAILDVEPQALKILRTAEFTPYVVFIAAPSLQNIADYDGSLE 845

  Fly  1953 EPFKEEELKDIIATARDMEARWGHLFDMIIINNDTERAYHQLLAEINSLEREPQWVPAQWVHNNR 2017
            ...||.|:         :...:||.||:.|:|||.......|...|:.:...|||||..|::...
  Fly   846 RLAKESEM---------LRQLYGHFFDLTIVNNDISETIATLETAIDRVHTTPQWVPVSWLYXQD 901

  Fly  2018 DE 2019
            .|
  Fly   902 SE 903

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
sdt	NP_001033835.2	PDZ_signaling	<54..102	CDD:238492
		L27	1423..1466	CDD:295425	14/49 (29%)
		PDZ_signaling	1562..1640	CDD:238492	28/79 (35%)
		SH3_MPP5	1673..1734	CDD:212969	34/63 (54%)
		Guanylate_kin	1820..1994	CDD:279019	56/174 (32%)
		GuKc	1831..2002	CDD:214504	55/171 (32%)
CASK	NP_001262811.1	STKc_CASK	8..308	CDD:270996	37/174 (21%)
		S_TKc	12..278	CDD:214567	30/144 (21%)
		L27	347..396	CDD:280918	10/61 (16%)
		L27	406..462	CDD:280918	15/55 (27%)
		PDZ_signaling	493..573	CDD:238492	28/79 (35%)
		SH3_CASK	586..646	CDD:213014	34/86 (40%)
		Guanylate_kin	710..883	CDD:279019	59/185 (32%)
		GuKc	720..883	CDD:214504	54/171 (32%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45468174
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0194
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR23122
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	4	3.840