DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment sdt and dlg4b

DIOPT Version :9

Sequence 1:	NP_001033835.2	Gene:	sdt / 44861	FlyBaseID:	FBgn0261873	Length:	2020	Species:	Drosophila melanogaster
Sequence 2:	NP_999893.1	Gene:	dlg4b / 405796	ZFINID:	ZDB-GENE-040628-3	Length:	801	Species:	Danio rerio

Alignment Length:	878	Identity:	198/878 - (22%)
Similarity:	321/878 - (36%)	Gaps:	262/878 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly  1236 PDRRAPGNASSGSSGATTH----------------PLQHQQIAQ-IVEPT-----------LEQL 1272
            |.:.:|.:.|:|.|....|                |..|...|: ::.|:           :..:
Zfish    81 PLQHSPAHLSTGKSAEMLHLGDSGHAPIDGIHAYTPQMHVSPAKPVLLPSGHAPYYATSTLMNGM 145

  Fly  1273 DSIKKYQEQLRRRREEEERIAQQNEFLRNSLRGSRKLKALQDTAT-------PGKAVAQQ----- 1325
            |...:|         ||..:.:.|..|..|:.|......:.|..:       ||.|.||.
Zfish   146 DGDVEY---------EEITLERGNSGLGFSIAGGTDNPHIGDDPSIFITKIIPGGAAAQDGRLRV 201

  Fly  1326 ----------------QQQATLATQVVGVENEAYLPDEDQPQAEQIDGYGELIAALTRLQNQLSK 1374
                            ...|..|.:..|.....|:. ..:|.||:|          |.|:.....
Zfish   202 NDSILFVNDVDVREVTHSFAVEALKEAGPIVRLYVL-RHKPSAEKI----------TELKLIKGP 255

  Fly  1375 SGLS-TLAGRVSAAH---------SVLASASVAH----------VLAARTAVLQRRRSRVSGPLH 1419
            .||. ::||.|...|         :.:.....||          :||.....|:.
Zfish   256 KGLGFSIAGGVGNQHVPGDNSIYVTKIIEGGAAHKDGRLQIGDKILAVNNMYLEE---------- 310

  Fly  1420 HSSLGLQKDIVELLTQSNTAAAIELGNLLTSHEMEGLLLAHDRIANHTDGTPSPTPTPTPAIGAA 1484
                .:.:|.|..|..:.....:.:...|..|.       |....|..|.|.|.:|
Zfish   311 ----VMHEDAVAALKNTGDVVFLRVAKTLHQHH-------HQDAYNPPDITSSYSP--------- 355

  Fly  1485 TGSTLSSPVAGPKRNLGMVVPPPVVPPPLAQRGAMPLPRGESPPPVPMPPLATMPMSMPVNLPMS 1549
                          ::.|...|..:.|...:|.: |:|:|                     |.:.
Zfish   356 --------------HMDMSDYPQALSPSSPRRYS-PIPKG---------------------LFLD 384

  Fly  1550 ACFGTLNDQNDNIRIIQIEKSTEPLGATV--RNEGEAVVIGRIVRGGAAEKSGLLHEGDEILEVN 1612
                  :|.:...|.:.|.:.:..||..:  ..:||.:.|..|:.||||:.||.|.:||:||.||
Zfish   385 ------DDISREPRRVVIHRGSTGLGFNIVGGEDGEGIFISFILAGGAADLSGELRKGDQILSVN 443

  Fly  1613 GQELRGKTVNEVCALLGAMQGTLTFLIVPAGSPPSVG------------VMGGTTGSQLAGLGGA 1665
            |.:||..|..:..|.|.....|:|  |:....|....            :|..:..|..|.|...
Zfish   444 GVDLRHATHEQAAAALKNAGQTVT--IITQYRPEEYSRFEAKIHDLREQLMNSSLVSAAASLRSG 506

  Fly  1666 HRDTAVLHVRAHFDYDPEDDLYIPCRELG------ISFQKGDVLHVISREDPNWWQAYR---EGE 1721
            .|.   ..:||.||||...|        |      :||:.||||.|....|..||||.:   .||
Zfish   507 KRS---FFIRALFDYDKTAD--------GGFLSQAVSFRFGDVLQVFDCSDEEWWQAGKLAPHGE 560

  Fly  1722 EDQTLAGLIPSQSFQHQRETMKLAIAEEAGLARSRGKDGSGSKGATLLCARKGRKKKKKASSEAG 1786
            .::|  |.|||:....::|..:|         ::||::                    ..|..:.
Zfish   561 LEET--GYIPSKRRVERKEWSRL---------KTRGRE--------------------PVSGRSD 594

  Fly  1787 YPLYATTAPDETDPEEILTYEEVALYYPRATHKRPIVLIGPPNIGRHELRQRLMAD-SERFSAAV 1850
            |               |::||.|.  .....:.||::::||   .:..:...|::: .::|.:.|
Zfish   595 Y---------------IVSYETVT--QSEVHYARPVIILGP---SKDRVNDDLLSEFPDKFGSCV 639

  Fly  1851 PHTSRARREGEVPGVDYHFI-TRQAFEADILARRFVEHGEYEKAYYGTSLEAIRTVV-ASGKICV 1913
            |||:|.:||.|:.|.||||: :|:..|.||.:.||:|.|:|....||||::::|.|. ..||.|:
Zfish   640 PHTTRPKREYEMDGRDYHFVSSREQMEKDIQSHRFIEAGQYNSHLYGTSVQSVRQVAEQQGKHCI 704

  Fly  1914 LNLHPQSLKLLRASDLKPYVVLVAPPSLDKLRQKKLRNGEPFKEEELKDIIATARDMEARWGHLF 1978
            |::...:::.|:|:.|.|..:.:.|.||    |..|...:...||:.:..:..|..:|..:...|
Zfish   705 LDVSANAVRRLQAAQLYPIAIFIRPSSL----QNVLNISKRLTEEQARRALDRAVKLEQDFIECF 765

  Fly  1979 DMIIINNDTERAYHQLLAEINSLEREPQWVPAQ 2011
            ..|:.....|..||.:.:.|........|:||:
Zfish   766 SAIVEGESFEEIYHHVKSVIEEQSGPYIWIPAR 798

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
sdt	NP_001033835.2	PDZ_signaling	<54..102	CDD:238492
		L27	1423..1466	CDD:295425	6/42 (14%)
		PDZ_signaling	1562..1640	CDD:238492	29/79 (37%)
		SH3_MPP5	1673..1734	CDD:212969	27/69 (39%)
		Guanylate_kin	1820..1994	CDD:279019	56/176 (32%)
		GuKc	1831..2002	CDD:214504	53/173 (31%)
dlg4b	NP_999893.1	L27_1	4..58	CDD:286187
		MAGUK_N_PEST	71..152	CDD:287565	12/79 (15%)
		PDZ	153..237	CDD:278991	15/83 (18%)
		PDZ	245..331	CDD:214570	17/109 (16%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	339..373		9/63 (14%)
		PDZ_assoc	342..392	CDD:287558	14/100 (14%)
		PDZ_signaling	391..471	CDD:238492	30/81 (37%)
		SH3	509..574	CDD:302595	27/77 (35%)
		Guanylate_kin	609..788	CDD:279019	57/185 (31%)
		GuKc	617..788	CDD:214504	55/177 (31%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910