Protein Alignment sdt and magu-2

DIOPT Version :10

• Sequence 1: NP_001033835.2
• Gene: sdt / 44861
• FlyBaseID: FBgn0261873
• Length: 2020
• Species: Drosophila melanogaster
• Sequence 2: NP_001355433.1
• Gene: magu-2 / 3565703
• WormBaseID: WBGene00006467
• Length: 830
• Species: Caenorhabditis elegans
• Alignment Length: 976
• Identity: 286/976 - (29%)
• Similarity: 446/976 - (45%)
• Gaps: 230/976 - (23%)

  Fly  1114 VDVPDSFIEMVKTTPRYPPPAHLSSRGSLLSNGSASTAHTTLSSMGVAPS------PVTATAAAA 1172
            |.:|.:..::.:|:.|     .|||...:.:..:..:..|.||...:...      .:..|||..
 Worm     5 VSIPQALSDLKRTSLR-----RLSSARGVGNKKTVVSTSTPLSGFVILVEREEKVVRLYGTAAER 64

  Fly  1173 ASASAACATTAVAAAAVSGVADGDA--------RRVADELNGNAKPVPPPRDHLRVEKDGRLVNC 1229
            |..|.......|....:.|.:..:.        ||...:|....:.:..|     .|.:..:.||
 Worm    65 AGLSIGDEIVGVNDMKIEGKSYEEVTTYIQECIRRKIIQLKVRRRALEIP-----AENEASVFNC 124

  Fly  1230 SPAPQLPDRRAPGNASSGSSGATTHPLQHQQIAQIVEPTLEQLDSIKKYQEQ------------- 1281
            :            |::...:.|....:....|.::.:...::...|..|..:
 Worm   125 T------------NSNRMITDAYLVSVDKDHIKEVTKRLKKEYPEIHTYDMEYIAATSGPPSVAP 177

  Fly  1282 ---------------LRR-----RREEEERIAQQNEFLRNSLRGSRKLKALQDTATP-------- 1318
                           |||     ..:|::|..|:|.|||:|||.|:||:||.....|
 Worm   178 RGSVHTNGFGIERGSLRRPPEQFEMQEKKRKEQENTFLRSSLRKSKKLQALARNVDPLTNEPMKV 242

  Fly  1319 ---GKAVAQQQQQATLATQ------VVG---VENEAYLPDEDQPQAEQIDGYGELIAALTRLQNQ 1371
               ...:|:.::..:..|:      .||   :|:...|.||:...:.|:|   |:|.::.|:
 Worm   243 TSFANPLAEVEETPSRKTENGATRITVGEEVLESSEVLIDEENKDSRQLD---EVIISVERI--- 301

  Fly  1372 LSKSGLSTLAGRVSAAHSVLASASVAHVLAARTAVLQRRRSRVSGPLHHSSLGLQKDIVELLTQS 1436
              .|.||::.||.|                 ..|:|   |...:.|      .:|..|.:.:.|:
 Worm   302 --ASKLSSMQGRES-----------------DVAML---RDFFAAP------PIQAAIEQTVKQN 338

  Fly  1437 NTAAAIELGNLLTSHEMEGLLLAHDRIANHTDGTPSPTPTPTPAIGAATGSTLSSPVAGPKRNLG 1501
            ........|                      .||.|         |..:.|..|||:
 Worm   339 GKCGTTSSG----------------------IGTDS---------GGDSSSCTSSPI-------- 364

  Fly  1502 MVVPPPVVPPPLAQRGAMPLPRGESPPPVPMPPLATMPMSMPVNLPMSACFGTLNDQNDNIRIIQ 1566
                     ||:...|     .|:|.   ..|..::.....|.|.|             |:::::
 Worm   365 ---------PPVIMNG-----NGKSE---RCPSTSSSSSVSPRNAP-------------NVKVVE 399

  Fly  1567 IEKSTEP-LGATVRNEGEAVVIGRIVRGGAAEKSGLLHEGDEILEVNGQELRGKTVNEVCALLGA 1630
            :.|..:. ||||||||...:::||:|:||..||..|..||||:||:||..|:||.|||:|.:|..
 Worm   400 VVKDEDSYLGATVRNENNKIIVGRVVKGGIVEKMNLFQEGDELLELNGSSLKGKQVNEICDILRN 464

  Fly  1631 MQGTLTFLIVPAGSPPSVGVMGGTTGSQLAGLGGAHRDTAVLHVRAHFDYDPEDDLYIPCRELGI 1695
            :.|.:||::.|.....:.......|.:..|.....|    |.|:||.||||||||:|:||:||.:
 Worm   465 LSGPITFVVAPKEEQDTEQPTDTATNTVTAKKSQQH----VQHLRALFDYDPEDDVYVPCKELAM 525

  Fly  1696 SFQKGDVLHVISREDPNWWQAYREGEEDQ-TLAGLIPSQSFQHQRETMKLAIAEEAGLARSRGKD 1759
            .||:||:|||::.:|.|||||||:||:.| :|||||||.||:.|    .:..|:|  :.|.:.:.
 Worm   526 KFQRGDILHVLNTKDDNWWQAYRDGEDIQHSLAGLIPSSSFRQQ----VVLYADE--VEREQEQK 584

  Fly  1760 GSGSKGATLLCARKGRKKKKKASSEAGYPLYATTAPDETDP-----EEILTYEEVALYYPRATHK 1819
            ....||          |||||...:.|       |.:|..|     .:.||||||.|..|:|||:
 Worm   585 RKECKG----------KKKKKLEVKKG-------ADEENLPAIGVYSDFLTYEEVVLELPKATHR 632

  Fly  1820 RPIVLIGPPNIGRHELRQRLMADSERFSAA--VPHTSRARREGEVPGVDYHFITRQAFEADILAR 1882
            |||||.|...:|..:||.||: :|:|.:.|  ||:|||..:|||..||.|||:::|.|..|..:.
 Worm   633 RPIVLCGAEGVGCLKLRDRLL-ESDRITLACPVPYTSRTPKEGEFNGVHYHFVSKQKFHEDAKSG 696

  Fly  1883 RFVEHGEYEKAYYGTSLEAIRTVVASGKICVLNLHPQSLKLLRASDLKPYVVLVAPPSLDKL-RQ 1946
            :|||.|||:|.:|||:.:.:..|:..||.||:.|..:||..:|:.|::||::.:|.|||..| ||
 Worm   697 KFVEFGEYQKFWYGTAKKDVVNVIERGKTCVMTLKAESLGAIRSPDIQPYIIFIAAPSLYILRRQ 761

  Fly  1947 KKLRNGEPFKEEELKDIIATARDMEARWGHLFDMIIINNDTERAYHQLLAEINSLEREPQWVPAQ 2011
            :::......|::|||.|:..::.:|.::|||||.||:|.|.|:::.:|...:..:..||.||||.
 Worm   762 REVEGTFGVKDDELKAILTQSKSIEQKYGHLFDGIIVNIDFEKSFRELKQILMKVNTEPMWVPAT 826

  Fly  2012 W 2012
            |
 Worm   827 W 827

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
sdt	NP_001033835.2	PDZ	<54..100	CDD:214570
		PDZ_MPP5-like	1563..1641	CDD:467259	36/78 (46%)
		SH3_MPP5	1673..1734	CDD:212969	41/61 (67%)
		GuKc	1831..2002	CDD:214504	70/173 (40%)
magu-2	NP_001355433.1	PDZ	<59..109	CDD:214570	10/49 (20%)
		PDZ_MPP5-like	406..475	CDD:467259	35/68 (51%)
		SH3_MPP5	503..565	CDD:212969	41/61 (67%)
		GuKc	642..817	CDD:214504	70/175 (40%)