DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment sdt and magu-2

DIOPT Version :9

Sequence 1:	NP_001033835.2	Gene:	sdt / 44861	FlyBaseID:	FBgn0261873	Length:	2020	Species:	Drosophila melanogaster
Sequence 2:	NP_001355433.1	Gene:	magu-2 / 3565703	WormBaseID:	WBGene00006467	Length:	830	Species:	Caenorhabditis elegans

Alignment Length:	976	Identity:	286/976 - (29%)
Similarity:	446/976 - (45%)	Gaps:	230/976 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly  1114 VDVPDSFIEMVKTTPRYPPPAHLSSRGSLLSNGSASTAHTTLSSMGVAPS------PVTATAAAA 1172
            |.:|.:..::.:|:.|     .|||...:.:..:..:..|.||...:...      .:..|||..
Worm     5 VSIPQALSDLKRTSLR-----RLSSARGVGNKKTVVSTSTPLSGFVILVEREEKVVRLYGTAAER 64

  Fly  1173 ASASAACATTAVAAAAVSGVADGDA--------RRVADELNGNAKPVPPPRDHLRVEKDGRLVNC 1229
            |..|.......|....:.|.:..:.        ||...:|....:.:..|     .|.:..:.||
Worm    65 AGLSIGDEIVGVNDMKIEGKSYEEVTTYIQECIRRKIIQLKVRRRALEIP-----AENEASVFNC 124

  Fly  1230 SPAPQLPDRRAPGNASSGSSGATTHPLQHQQIAQIVEPTLEQLDSIKKYQEQ------------- 1281
            :            |::...:.|....:....|.::.:...::...|..|..:
Worm   125 T------------NSNRMITDAYLVSVDKDHIKEVTKRLKKEYPEIHTYDMEYIAATSGPPSVAP 177

  Fly  1282 ---------------LRR-----RREEEERIAQQNEFLRNSLRGSRKLKALQDTATP-------- 1318
                           |||     ..:|::|..|:|.|||:|||.|:||:||.....|
Worm   178 RGSVHTNGFGIERGSLRRPPEQFEMQEKKRKEQENTFLRSSLRKSKKLQALARNVDPLTNEPMKV 242

  Fly  1319 ---GKAVAQQQQQATLATQ------VVG---VENEAYLPDEDQPQAEQIDGYGELIAALTRLQNQ 1371
               ...:|:.::..:..|:      .||   :|:...|.||:...:.|:|   |:|.::.|:
Worm   243 TSFANPLAEVEETPSRKTENGATRITVGEEVLESSEVLIDEENKDSRQLD---EVIISVERI--- 301

  Fly  1372 LSKSGLSTLAGRVSAAHSVLASASVAHVLAARTAVLQRRRSRVSGPLHHSSLGLQKDIVELLTQS 1436
              .|.||::.||.|                 ..|:|   |...:.|      .:|..|.:.:.|:
Worm   302 --ASKLSSMQGRES-----------------DVAML---RDFFAAP------PIQAAIEQTVKQN 338

  Fly  1437 NTAAAIELGNLLTSHEMEGLLLAHDRIANHTDGTPSPTPTPTPAIGAATGSTLSSPVAGPKRNLG 1501
            ........|                      .||.|         |..:.|..|||:
Worm   339 GKCGTTSSG----------------------IGTDS---------GGDSSSCTSSPI-------- 364

  Fly  1502 MVVPPPVVPPPLAQRGAMPLPRGESPPPVPMPPLATMPMSMPVNLPMSACFGTLNDQNDNIRIIQ 1566
                     ||:...|     .|:|.   ..|..::.....|.|.|             |:::::
Worm   365 ---------PPVIMNG-----NGKSE---RCPSTSSSSSVSPRNAP-------------NVKVVE 399

  Fly  1567 IEKSTEP-LGATVRNEGEAVVIGRIVRGGAAEKSGLLHEGDEILEVNGQELRGKTVNEVCALLGA 1630
            :.|..:. ||||||||...:::||:|:||..||..|..||||:||:||..|:||.|||:|.:|..
Worm   400 VVKDEDSYLGATVRNENNKIIVGRVVKGGIVEKMNLFQEGDELLELNGSSLKGKQVNEICDILRN 464

  Fly  1631 MQGTLTFLIVPAGSPPSVGVMGGTTGSQLAGLGGAHRDTAVLHVRAHFDYDPEDDLYIPCRELGI 1695
            :.|.:||::.|.....:.......|.:..|.....|    |.|:||.||||||||:|:||:||.:
Worm   465 LSGPITFVVAPKEEQDTEQPTDTATNTVTAKKSQQH----VQHLRALFDYDPEDDVYVPCKELAM 525

  Fly  1696 SFQKGDVLHVISREDPNWWQAYREGEEDQ-TLAGLIPSQSFQHQRETMKLAIAEEAGLARSRGKD 1759
            .||:||:|||::.:|.|||||||:||:.| :|||||||.||:.|    .:..|:|  :.|.:.:.
Worm   526 KFQRGDILHVLNTKDDNWWQAYRDGEDIQHSLAGLIPSSSFRQQ----VVLYADE--VEREQEQK 584

  Fly  1760 GSGSKGATLLCARKGRKKKKKASSEAGYPLYATTAPDETDP-----EEILTYEEVALYYPRATHK 1819
            ....||          |||||...:.|       |.:|..|     .:.||||||.|..|:|||:
Worm   585 RKECKG----------KKKKKLEVKKG-------ADEENLPAIGVYSDFLTYEEVVLELPKATHR 632

  Fly  1820 RPIVLIGPPNIGRHELRQRLMADSERFSAA--VPHTSRARREGEVPGVDYHFITRQAFEADILAR 1882
            |||||.|...:|..:||.||: :|:|.:.|  ||:|||..:|||..||.|||:::|.|..|..:.
Worm   633 RPIVLCGAEGVGCLKLRDRLL-ESDRITLACPVPYTSRTPKEGEFNGVHYHFVSKQKFHEDAKSG 696

  Fly  1883 RFVEHGEYEKAYYGTSLEAIRTVVASGKICVLNLHPQSLKLLRASDLKPYVVLVAPPSLDKL-RQ 1946
            :|||.|||:|.:|||:.:.:..|:..||.||:.|..:||..:|:.|::||::.:|.|||..| ||
Worm   697 KFVEFGEYQKFWYGTAKKDVVNVIERGKTCVMTLKAESLGAIRSPDIQPYIIFIAAPSLYILRRQ 761

  Fly  1947 KKLRNGEPFKEEELKDIIATARDMEARWGHLFDMIIINNDTERAYHQLLAEINSLEREPQWVPAQ 2011
            :::......|::|||.|:..::.:|.::|||||.||:|.|.|:::.:|...:..:..||.||||.
Worm   762 REVEGTFGVKDDELKAILTQSKSIEQKYGHLFDGIIVNIDFEKSFRELKQILMKVNTEPMWVPAT 826

  Fly  2012 W 2012
            |
Worm   827 W 827

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
sdt	NP_001033835.2	PDZ_signaling	<54..102	CDD:238492
		L27	1423..1466	CDD:295425	4/42 (10%)
		PDZ_signaling	1562..1640	CDD:238492	36/78 (46%)
		SH3_MPP5	1673..1734	CDD:212969	41/61 (67%)
		Guanylate_kin	1820..1994	CDD:279019	75/176 (43%)
		GuKc	1831..2002	CDD:214504	70/173 (40%)
magu-2	NP_001355433.1	PDZ	<59..107	CDD:238080	10/47 (21%)
		PDZ_signaling	408..474	CDD:238492	35/65 (54%)
		SH3_MPP5	503..565	CDD:212969	41/61 (67%)
		GuKc	642..817	CDD:214504	70/175 (40%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160161934
Domainoid	1	1.000	150	1.000	Domainoid score	I2697
eggNOG	1	0.900	-	-		E1_COG0194
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	466	1.000	Inparanoid score	I852
Isobase	1	0.950	-	0	Normalized mean entropy	S2106
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000824
OrthoInspector	1	1.000	-	-		otm14545
orthoMCL	1	0.900	-	-		OOG6_107065
Panther	1	1.100	-	-	LDO	PTHR23122
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X4595
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	14	13.700