DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment sdt and Mpp7

DIOPT Version :9

Sequence 1:	NP_001033835.2	Gene:	sdt / 44861	FlyBaseID:	FBgn0261873	Length:	2020	Species:	Drosophila melanogaster
Sequence 2:	XP_017456050.1	Gene:	Mpp7 / 307035	RGDID:	1305675	Length:	601	Species:	Rattus norvegicus

Alignment Length:	708	Identity:	224/708 - (31%)
Similarity:	359/708 - (50%)	Gaps:	168/708 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly  1357 GYGELIAAL-TRLQ----NQLSKSGLSTLAGRVSAAHSVLASASVAHVLAARTAVLQRRRSRVSG 1416
            |..||:||| .:||    :|...:.|..:.|..| .||::......|....::.|
  Rat    13 GLYELLAALPAQLQPHVDSQEDLTFLWDMFGEKS-LHSLVKIHEKLHYYEKQSPV---------- 66

  Fly  1417 PLHHSSLGLQKDIV-ELLTQSNTAAAIELGNLLTSHEMEGLLLAHDRIANHTDGTPSPTPTPTPA 1480
            |:.|.:..|..|:. ||..:...:...||..||:...::.||..||.:|..:
  Rat    67 PILHGAAALADDLADELQNKPPNSEIRELLKLLSKPNVKALLSVHDTVAQKS------------- 118

  Fly  1481 IGAATGSTLSSPVAGPKRNLGMVVPPPVVPPPLAQRGAMPLPRGESPPPVPMPPLATMPMSMPVN 1545
                                    ..||:||                              ||
  Rat   119 ------------------------YDPVLPP------------------------------MP-- 127

  Fly  1546 LPMSACFGTLNDQNDNIRIIQIEKSTEPLGATVRNEGE--AVVIGRIVRGGAAEKSGLLHEGDEI 1608
                   ..::|:.|:::||::.|:.||||||::.:.:  |:.:.||:|||||::|||:|.|||:
  Rat   128 -------DDIDDEEDSVKIIRLVKNREPLGATIKKDEQTGAITVARIMRGGAADRSGLIHVGDEL 185

  Fly  1609 LEVNGQELRGKTVNEVCALLGAMQGTLTFLIVPAGSPPSVGVMGGTTGSQLAGLGGAHRDTAVLH 1673
            .||||..:..|...|:..:|...||.:||.|:|            :|..::....|.      :.
  Rat   186 REVNGIPVEDKRPEEIIQILSQSQGAITFKIIP------------STKEEIPSKEGK------IF 232

  Fly  1674 VRAHFDYDPEDDLYIPCRELGISFQKGDVLHVISREDPNWWQAYREGEEDQTLAGLIPSQSFQHQ 1738
            ::|.|||||::|..|||:|.|:||:|||:|.::|::|..||||..||:.:.. ||||||:.||.:
  Rat   233 IKALFDYDPKEDKAIPCKEAGLSFRKGDILQIMSQDDATWWQAKHEGDTNPR-AGLIPSKHFQER 296

  Fly  1739 R----------ETMKLA-------------IAEEAGLARSRGKDGSGSKGATLLCARK----GRK 1776
            |          :.:||:             |.|:|      |.||:.| |..:...|:    .||
  Rat   297 RLALRRPEIVVQPLKLSNRKSYEETVECEEIKEDA------GHDGNNS-GPYIAGFRRSFRLSRK 354

  Fly  1777 KKKKASSEAGYPLYATTAPDETDPEEILTYEEVALYYPRATHK--RPIVLIGPPNIGRHELRQR- 1838
            .||...|     :|.....::.|..::.|||||. .|.|.||.  |.:||:||..:|.:||:::
  Rat   355 DKKTNKS-----MYECKKSEQYDTADVPTYEEVT-PYRRQTHDKYRLVVLVGPVGVGLNELKRKL 413

  Fly  1839 LMADSERFSAAVPHTSRARREGEVPGVDYHFITRQAFEADILARRFVEHGEYEKAYYGTSLEAIR 1903
            ||:|::.:...||||:||||..|..||:|.||::..||.|:...:|:|:|||:..|||||::::|
  Rat   414 LMSDTQHYGVTVPHTTRARRSQESDGVEYIFISKHLFETDVQNNKFIEYGEYKNNYYGTSIDSVR 478

  Fly  1904 TVVASGKICVLNLHPQSLKLLRASDLKPYVVLVAPPSLDKLRQKKLR-----------NGEPFKE 1957
            :|:|..|:|:|::.|.::|.||..:.||||:.:.|||:::||:.:..           ..:||.|
  Rat   479 SVLAKNKVCLLDVQPHTVKHLRTLEFKPYVIFIKPPSIERLRETRKNAKIISSRDDQGTAKPFTE 543

  Fly  1958 EELKDIIATARDMEARWGHLFDMIIINNDTERAYHQLLAEINSLEREPQWVPAQWVHN 2015
            |:.:::|.:|:.||:::|||||.||||:|...|:::|....:.||.:..|||..|:|:
  Rat   544 EDFQEMIKSAQIMESQYGHLFDKIIINDDLTVAFNELKTTFDKLETDAHWVPVSWLHS 601

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
sdt	NP_001033835.2	PDZ_signaling	<54..102	CDD:238492
		L27	1423..1466	CDD:295425	13/43 (30%)
		PDZ_signaling	1562..1640	CDD:238492	35/79 (44%)
		SH3_MPP5	1673..1734	CDD:212969	32/60 (53%)
		Guanylate_kin	1820..1994	CDD:279019	76/185 (41%)
		GuKc	1831..2002	CDD:214504	72/182 (40%)
Mpp7	XP_017456050.1	L27	16..68	CDD:197794	15/62 (24%)
		L27	<88..125	CDD:197794	11/73 (15%)
		PDZ_signaling	137..217	CDD:238492	35/79 (44%)
		SH3_MPP7	232..292	CDD:212966	32/60 (53%)
		GuKc	409..588	CDD:214504	70/178 (39%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0194
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D245552at33208
OrthoFinder	1	1.000	-	-		FOG0000824
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.820