DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment sdt and mpp7a

DIOPT Version :9

Sequence 1:	NP_001033835.2	Gene:	sdt / 44861	FlyBaseID:	FBgn0261873	Length:	2020	Species:	Drosophila melanogaster
Sequence 2:	XP_021335692.1	Gene:	mpp7a / 30166	ZFINID:	ZDB-GENE-991209-8	Length:	621	Species:	Danio rerio

Alignment Length:	689	Identity:	214/689 - (31%)
Similarity:	341/689 - (49%)	Gaps:	159/689 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly  1417 PLHHSSLGLQKDIVELLT--QSNTAAAIE-------LGNLLTSHEMEGLLLAHDRIANHTDGTPS 1472
            |...|..|.:..:.|||:  .|.....:|       |..:.....:..|:..|:::..:.|..|:
Zfish     2 PALSSRSGSEMGLYELLSVLPSQLQPHVESPDDRSFLHAMFGERSLHSLVKIHEKLQCYEDCAPT 66

  Fly  1473 PTPTPTPAIGAATGSTLSSPVAGPK-RNLGMVVPPPVVPPPLAQRGAMPLPRGESP--PPVPMPP 1534
            |......::.|.....|.:..|..: |.|..::..|.|...|:....: ..:...|  ||:|
Zfish    67 PVLDSAGSLAADLTEELQARSASNEIRELVKLLSKPHVKSLLSVHDTV-AKKSYDPELPPLP--- 127

  Fly  1535 LATMPMSMPVNLPMSACFGTLNDQNDNIRIIQIEKSTEPLGATVRNEGE--AVVIGRIVRGGAAE 1597
                              ..::|:.|:::||::.|:.||||||::.:..  |:::.||:|||||:
Zfish   128 ------------------DDIDDEEDSVKIIRLVKNKEPLGATIKKDEHTGAILVARILRGGAAD 174

  Fly  1598 KSGLLHEGDEILEVNGQELRGKTVNEVCALLGAMQGTLTFLIVPAGSPPSVGVMGGTTGSQLAGL 1662
            :|||:|.|||:.||||..:..|...|:..:|...||.:||.:||       |:
Zfish   175 RSGLIHVGDELKEVNGIPVDDKKPEEIIRILSQSQGAITFKVVP-------GI------------ 220

  Fly  1663 GGAHRDTA-----VLHVRAHFDYDPEDDLYIPCRELGISFQKGDVLHVISREDPNWWQAYREGEE 1722
                :|.|     .:.::|.|||:|.:|..|||:|.|:.|:|||:|.|:|::|..||||..|| :
Zfish   221 ----KDEAQSKEPKMFIKALFDYNPAEDKAIPCKEAGLGFKKGDILQVMSQDDATWWQAKLEG-D 280

  Fly  1723 DQTLAGLIPSQSFQHQR----------------------ETMKLA--IAEE------------AG 1751
            ....||||||:.||.:|                      :|:...  |.||            ||
Zfish   281 GNLRAGLIPSKHFQERRLAVWRPTPVMTLQRTSSKRFYDDTVNCVEDIEEENEFASYLSGLHVAG 345

  Fly  1752 LARSRGKDGSGSKGATLLCARKGRKKKKKASSEAGYPLYATTAPDETDPEEILTYEEVALYYPRA 1816
            |.||               .|..|:.||...|     :|.....::.|..::.|||||..|  |.
Zfish   346 LRRS---------------FRLSRRDKKTNKS-----MYECKKSEQYDTADVPTYEEVTTY--RR 388

  Fly  1817 TH---KRPIVLIGPPNIGRHELRQRLM-ADSERFSAAVPHTSRARREGEVPGVDYHFITRQAFEA 1877
            .|   .|.:||:||..:|.:||:::|: :|::.||..:|||||::|..|..||:||||::..|||
Zfish   389 KHGDRHRLVVLVGPTGVGLNELKRKLLISDTQHFSVTIPHTSRSKRHQESEGVEYHFISKNLFEA 453

  Fly  1878 DI------------------LAR-RFVEHGEYEKAYYGTSLEAIRTVVASGKICVLNLHPQSLKL 1923
            ||                  |.| ||:|||||:..|||||.:::|:|::..|:|:|::.|.:||.
Zfish   454 DIQNNKKSGYSCFWRSSLPVLQRNRFIEHGEYKGNYYGTSFDSVRSVLSKNKVCLLDVQPHTLKH 518

  Fly  1924 LRASDLKPYVVLVAPPSLDKLRQKKLRN------------GEPFKEEELKDIIATARDMEARWGH 1976
            ||.::.|||||.|.||.:::||:.: ||            .:.|.||:..::|:.::.||.::||
Zfish   519 LRTAEFKPYVVFVKPPCIERLRETR-RNAKVISGKDDKTSSKAFSEEDFLEMISASQMMENQYGH 582

  Fly  1977 LFDMIIINNDTERAYHQLLAEINSLEREPQWVPAQWVHN 2015
            ||:.:|:|:|...|:.:|...:..:|.|..|||..|.|:
Zfish   583 LFEKVIVNDDLTVAFSELKQALKKVETEAHWVPISWTHS 621

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
sdt	NP_001033835.2	PDZ_signaling	<54..102	CDD:238492
		L27	1423..1466	CDD:295425	9/51 (18%)
		PDZ_signaling	1562..1640	CDD:238492	35/79 (44%)
		SH3_MPP5	1673..1734	CDD:212969	31/60 (52%)
		Guanylate_kin	1820..1994	CDD:279019	80/205 (39%)
		GuKc	1831..2002	CDD:214504	76/202 (38%)
mpp7a	XP_021335692.1	L27	12..68	CDD:197794	10/55 (18%)
		L27	74..125	CDD:197794	9/51 (18%)
		PDZ_signaling	137..217	CDD:238492	35/79 (44%)
		SH3	232..292	CDD:327375	31/60 (52%)
		GuKc	403..608	CDD:214504	76/205 (37%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D245552at33208
OrthoFinder	1	1.000	-	-		FOG0000824
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	4	3.920