DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment sdt and Lrguk

DIOPT Version :9

Sequence 1:	NP_001033835.2	Gene:	sdt / 44861	FlyBaseID:	FBgn0261873	Length:	2020	Species:	Drosophila melanogaster
Sequence 2:	XP_017448017.1	Gene:	Lrguk / 296968	RGDID:	1308226	Length:	1271	Species:	Rattus norvegicus

Alignment Length:	443	Identity:	97/443 - (21%)
Similarity:	165/443 - (37%)	Gaps:	103/443 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly  1601 LLHEGDEILEVNGQE---------LRGKTVNEVCALLGAMQGTLTFLIVPAGSPPSVGVMGGTTG 1656
            |:.:.:||.|:.|.|         |.|..:..:..|     |||...::...:.....:.|....
  Rat   220 LILDNNEIEEITGLEKCISLTHLSLAGNRITTIKGL-----GTLPIKVLSVSNNQIETITGLEEL 279

  Fly  1657 SQLAGLGGAHRDTAVLHVRAHFDYDPEDDLYIPCRELGISFQKGDVLHVISREDPNWWQAYREGE 1721
            ..|..|..:|...:.||                      ..:..|:|.||:.|| |..:...|.|
  Rat   280 KALQNLDLSHNQISSLH----------------------GLENHDLLEVINLED-NKIKELSEIE 321

  Fly  1722 EDQTLAGLIPSQSFQHQRET----------MKLAIAEEAGLARSRGKDGSGSKGATLLCARKGRK 1776
            ..:.|..|......::..:|          |.|.:.|   |.:.:.|                .:
  Rat   322 YIENLPILRVLNLLRNPIQTKPEYWFFVIFMLLRLTE---LDQQKIK----------------VE 367

  Fly  1777 KKKKASSEAGYPLYATTAPDE--------TDPEEIL--TYEEVALYYPRATHKRPIVLIGPPNIG 1831
            :|..|.::...|.....|.|.        :.|:.|.  |...:...||.      ::|.||...|
  Rat   368 EKVYAVNKYDPPPEVVAAQDHMTHVVNSMSQPQRIFDSTLPSLDAPYPM------LILTGPEACG 426

  Fly  1832 RHELRQRLMAD-SERFSAAVPHTSRARREGEVPGVDYHFITRQAFEADILARRFVEHGEYEKAYY 1895
            :.||..||... |..|.....||:|....||...|||||::::.|:..:...:|:....|....|
  Rat   427 KRELAHRLCRQFSTYFRYGACHTTRPPYFGEGDRVDYHFVSQEVFDEMLSMGKFILTFNYGNHNY 491

  Fly  1896 GTSLEAIRTVVASGKICVLNLHPQSLKLLRASDLKPYVVLVAPPSLDK----LRQKKLRNGEPFK 1956
            |.:.:.:..:...|....:::..:.::.|:.|..:|..:||.|...:|    ||:|.|     |.
  Rat   492 GLNRDTVEGIARDGLASCIHMELEGIRSLKYSYFEPRYILVVPMDKEKYEGYLRRKGL-----FS 551

  Fly  1957 EEELKDIIATAR-----DMEARWGHLFDMIIINNDTERAYHQLLAEINSLERE 2004
            ..|::  ||.:|     .:..::...||.:|..:|.:.||.:|    :.|.||
  Rat   552 RAEIE--IAVSRVDLYVKVNRKFPGYFDAVINADDLDIAYQKL----SELIRE 598

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
sdt	NP_001033835.2	PDZ_signaling	<54..102	CDD:238492
		L27	1423..1466	CDD:295425
		PDZ_signaling	1562..1640	CDD:238492	12/47 (26%)
		SH3_MPP5	1673..1734	CDD:212969	12/60 (20%)
		Guanylate_kin	1820..1994	CDD:279019	48/183 (26%)
		GuKc	1831..2002	CDD:214504	46/180 (26%)
Lrguk	XP_017448017.1	None
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0194
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810