Protein Alignment sdt and Cask

DIOPT Version :10

• Sequence 1: NP_001033835.2
• Gene: sdt / 44861
• FlyBaseID: FBgn0261873
• Length: 2020
• Species: Drosophila melanogaster
• Sequence 2: XP_038955486.1
• Gene: Cask / 29647
• RGDID: 62004
• Length: 932
• Species: Rattus norvegicus
• Alignment Length: 824
• Identity: 217/824 - (26%)
• Similarity: 351/824 - (42%)
• Gaps: 198/824 - (24%)

  Fly  1254 HPLQHQQIAQIVEP------TLEQLDSIKKYQEQLRRRREEEERIA------QQNEFLRNSLRGS 1306
            :|.|...|::..:.      .|:..:.|..|:.......:|.:|.|      :..|.|| .....
  Rat   244 NPRQWSHISESAKDLVRRMLMLDPAERITVYEALNHPWLKERDRYAYKIHLPETVEQLR-KFNAR 307

  Fly  1307 RKLKALQDTATPGKAVAQQQQQATLATQVVGVENEAY------LPD--ED----------QPQAE 1353
            ||||.                 |.||.......|..|      |||  ||          :..::
  Rat   308 RKLKG-----------------AVLAAVSSHKFNSFYGDPPEELPDFSEDPTSSGLLAAERAVSQ 355

  Fly  1354 QIDGYGELIAALTRLQNQLSKSGLSTLAGRVSAAHSVLASASVAHVLAARTAVLQRRRSRVSGPL 1418
            .:|...| |.|||    ..|:..|..|       |||.....:..:|.....:..:...::..|
  Rat   356 VLDSLEE-IHALT----DCSEKDLDFL-------HSVFQDQHLHTLLDLYDKINTKSSPQIRNP- 407

  Fly  1419 HHSSLGLQKDIVELLT---QSNTAAAIELGNLLTSHEMEGLLLAHDRIAN--HTDGTPSPTPTPT 1478
            ...::...|:::|.::   ::|.|.  ||..:||......||..||.:|:  ::|.....||.||
  Rat   408 PSDAVQRAKEVLEEISCYPENNDAK--ELKRILTQPHFMALLQTHDVVAHEVYSDEALRVTPPPT 470

  Fly  1479 PAIGAATGSTLSSPVAGPKRNLGMVVPPPVVPPPLAQRGAMPLPRGESPPPVPMPPLATMPMSMP 1543
                                                    .|...|:||
  Rat   471 ----------------------------------------SPYLNGDSP---------------- 479

  Fly  1544 VNLPMSACFGTLNDQN-DNIRIIQIEKST-EPLGATVR-NEGEAVVIGRIVRGGAAEKSGLLHEG 1605
                 .:..|.::.:| ..:|::|.:|:| ||:|.|:: ||....::.||:.||...:.|.||.|
  Rat   480 -----ESANGDMDMENVTRVRLVQFQKNTDEPMGITLKMNELNHCIVARIMHGGMIHRQGTLHVG 539

  Fly  1606 DEILEVNGQELRGKTVNEVCALLGAMQGTLTFLIVPA----------GSPPSVGVMGGTTGSQLA 1660
            |||.|:||..:..:||.::..:|..|:|::||.|||:          .||        :|..|..
  Rat   540 DEIREINGISVANQTVEQLQKMLREMRGSITFKIVPSYRTQSSSCERDSP--------STSRQSP 596

  Fly  1661 GLGGAHRDTAV-------------LHVRAHFDYDPEDDLYIPCRELGISFQKGDVLHVISREDPN 1712
            ..|.:..:.:|             ::|||.|:|||..|..|||:|.||.|:.||::.:||::|.|
  Rat   597 ANGHSSTNNSVSDLPSTTQPKGRQIYVRAQFEYDPAKDDLIPCKEAGIRFRVGDIIQIISKDDHN 661

  Fly  1713 WWQAYREGEEDQTLAGLIPSQSFQHQRETMKLAIAEEAGLARSRGKDGSGSKGATLLCARKGRKK 1777
            |||...|..::.| ||||||...|..|         .|.:|..:.|....:.     |...|:||
  Rat   662 WWQGKLENSKNGT-AGLIPSPELQEWR---------VACIAMEKTKQEQQAS-----CTWFGKKK 711

  Fly  1778 KKKASSEAGYPLYATTAPDETDPEEILTYEEVALYYPRATHKRPIVLIGPPNIGRHELRQRLMA- 1841
            |:....      |........|..:::||||| :..| |..::.:||:|...:||..::..|:.
  Rat   712 KQYKDK------YLAKHNAVFDQLDLVTYEEV-VKLP-AFKRKTLVLLGAHGVGRRHIKNTLITK 768

  Fly  1842 DSERFSAAVPHTSRARREGEVPGVDYHFITRQAFEADILARRFVEHGEYEKAYYGTSLEAIRTVV 1906
            ..|||:..:|||:|..::.|..|.:|:|::......||....::|:|.:|.|.|||.||.||.:.
  Rat   769 HPERFAYPIPHTTRPPKKDEENGKNYYFVSHDQMMQDISNNEYLEYGSHEDAMYGTKLETIRKIH 833

  Fly  1907 ASGKICVLNLHPQSLKLLRASDLKPYVVLVAPPSLDK-LRQKKLRNGEPFKEEELKDIIATARDM 1970
            ..|.|.:|::.||:||:||.::..|:||.:|.|::.. |.:          :|.|:.:...:..:
  Rat   834 EQGLIAILDVEPQALKVLRTAEFAPFVVFIAAPTITPGLNE----------DESLQRLQKESDVL 888

  Fly  1971 EARWGHLFDMIIINNDTERAYHQLLAEINSLEREPQWVPAQWVH 2014
            :..:.|.||:.||||:.:.....|...:..:...|||||..||:
  Rat   889 QRTYAHYFDLTIINNEIDETIRHLEEAVELVCTAPQWVPVSWVY 932

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
sdt	NP_001033835.2	PDZ	<54..100	CDD:214570
		PDZ_MPP5-like	1563..1641	CDD:467259	32/79 (41%)
		SH3_MPP5	1673..1734	CDD:212969	32/60 (53%)
		GuKc	1831..2002	CDD:214504	52/172 (30%)
Cask	XP_038955486.1	STKc_CASK	8..313	CDD:270996	16/86 (19%)
		L27	354..407	CDD:197794	13/64 (20%)
		L27	412..462	CDD:460717	14/51 (27%)
		PDZ_CASK-like	495..575	CDD:467267	32/79 (41%)
		SH3_CASK	622..683	CDD:213014	32/61 (52%)
		Guanylate_kin	744..917	CDD:395500	55/182 (30%)