DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment sdt and Dlg1

DIOPT Version :9

Sequence 1:	NP_001033835.2	Gene:	sdt / 44861	FlyBaseID:	FBgn0261873	Length:	2020	Species:	Drosophila melanogaster
Sequence 2:	XP_038943929.1	Gene:	Dlg1 / 25252	RGDID:	2505	Length:	939	Species:	Rattus norvegicus

Alignment Length:	1028	Identity:	237/1028 - (23%)
Similarity:	400/1028 - (38%)	Gaps:	250/1028 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly  1059 SATSSSSATSSSTVPDDLSLAPPGYEVSQQQQQQHLVATPVTMLLPPMAKHRELPVDVPDSFIEM 1123
            |.:.||:|.:|.::|..||  ||..:...|.::          :||    ...:...||:..:.
  Rat    84 SGSLSSAAVTSESLPGGLS--PPVEKYRYQDEE----------VLP----SERISPQVPNEVLG- 131

  Fly  1124 VKTTPRYPPPAHLSSRG-SLLSNGSASTAHTTLSSMGVAPSPVTATAAAAASASAACATTAVAAA 1187
                   |...|:|.:. |.:.|.....:|:.:       ||:..|.|...|:.....|.|:...
  Rat   132 -------PELVHVSEKSLSEIENVHGFVSHSHI-------SPIKPTEAVPPSSPIVPVTPALPVP 182

  Fly  1188 AVSGVADGDARRVADELNGNAKPVPPPRDHLRVEKDG----RLVNCSPA----PQLPDRRAPGNA 1244
            |.|.|.          |....:..|||   :.|..|.    ..||.:.|    .::...|  ||:
  Rat   183 AESPVV----------LPSTPQANPPP---VLVNTDSLETPTYVNGTDADYEYEEITLER--GNS 232

  Fly  1245 SSGSS--GATTHPLQHQQ----IAQIVEPTLEQLDSIKKYQEQLRRRREEEERIAQQNEFLRNSL 1303
            ..|.|  |.|.:|.....    |.:|:.......|...:..:.:.|..|.:.|          .:
  Rat   233 GLGFSIAGGTDNPHIGDDSSIFITKIITGGAAAQDGRLRVNDCILRVNEADVR----------DV 287

  Fly  1304 RGSRKLKALQDTATPGKAVAQQQQQATLATQVVGVENEAYLPDEDQPQAEQIDGYGELIAALTRL 1368
            ..|:.::||::..:..:...:::                      :|.:|:|            :
  Rat   288 THSKAVEALKEAGSIVRLYVKRR----------------------KPASEKI------------M 318

  Fly  1369 QNQLSK--SGLS-TLAGRVSAAHSVLASASVAHVLAARTAVLQRRRSRVSGPLHHSSLGLQKDIV 1430
            :.:|.|  .||. ::||.|...|  :...:..:|    |.:::...:...|.|         .|.
  Rat   319 EIKLIKGPKGLGFSIAGGVGNQH--IPGDNSIYV----TKIIEGGAAHKDGKL---------QIG 368

  Fly  1431 ELLTQSNTAAAIELGNLLTSHEMEGLLLAHDRIANHTDGTPSPTPTPTPAIGAATGSTLSSPVAG 1495
            :.|...|:....|:     :||.     |...:.|.:|........||
  Rat   369 DKLLAVNSVCLEEV-----THEE-----AVTALKNTSDFVYLKVAKPT----------------- 406

  Fly  1496 PKRNLGMVVPPPVVPPPLAQRGAMPLPRGESPP----PVPMPPLATMPMSMPVNLPMSACFGTLN 1556
                 .|.:.....||.:....:..:....||.    ..|..|....|:|..|          |.
  Rat   407 -----SMYINDGYAPPDITNSSSQSVDNHVSPSSYLGQTPASPARYSPISKAV----------LG 456

  Fly  1557 DQNDNI----RIIQIEKSTEPLGATV--RNEGEAVVIGRIVRGGAAEKSGLLHEGDEILEVNGQE 1615
            |  |.|    |.:.:.:.:..||..:  ..:||.:.|..|:.||.|:.||.|.:||.|:.||..:
  Rat   457 D--DEITREPRKVVLHRGSTGLGFNIVGGEDGEGIFISFILAGGPADLSGELRKGDRIISVNSVD 519

  Fly  1616 LRGKTVNEVCALLGAMQGTLTFLIVPAGSPPSVG------------VMGGTTGSQLAGLGGAHRD 1668
            ||..:..:..|.|......:|  ||....|....            :|..:..|....|..:.:.
  Rat   520 LRAASHEQAAAALKNAGQAVT--IVAQYRPEEYSRFEAKIHDLREQMMNSSVSSGSGSLRTSQKR 582

  Fly  1669 TAVLHVRAHFDYDPEDDLYIPCRELGISFQKGDVLHVISREDPNWWQAYR---EGEEDQTLAGLI 1730
            :  |:|||.||||...|..:|.:  |::|:.||:||||:..|..||||.:   :||.|:  .|:|
  Rat   583 S--LYVRALFDYDKTKDSGLPSQ--GLNFKFGDILHVINASDDEWWQARQVTPDGESDE--VGVI 641

  Fly  1731 PSQSFQHQRETMKLAIAEEAGLARSRGKDGS--GSKGATLLCARKGRKKKKK------------- 1780
            ||:....::|..:|...:..  :::||..|.  ..|....|.:||....|.|
  Rat   642 PSKRRVEKKERARLKTVKFN--SKTRGDKGQSFNDKRKKNLFSRKFPFYKNKDQSEQETSDADQH 704

  Fly  1781 -----ASSEAGYPLYATTAPDE------TDPEEILTYEEVALYYPRATHKRPIVLIGPPNIGRHE 1834
                 :.||:.|.:..|   ||      ...|.:|:||.|  ......:.||::::||
  Rat   705 VTSNASDSESSYLILIT---DEYGCSKGGQEEYVLSYEPV--NQQEVNYTRPVIILGP------- 757

  Fly  1835 LRQRLMAD-----SERFSAAVPHTSRARREGEVPGVDYHFIT-RQAFEADILARRFVEHGEYEKA 1893
            ::.|:..|     .::|.:.||||:|.:|:.||.|.||||:| |:..|.||...:|:|.|:|...
  Rat   758 MKDRVNDDLISEFPDKFGSCVPHTTRPKRDYEVDGRDYHFVTSREQMEKDIQEHKFIEAGQYNNH 822

  Fly  1894 YYGTSLEAIRTVVASGKICVLNLHPQSLKLLRASDLKPYVVLVAPPSLDKLRQKKLRNGEPFKEE 1958
            .||||::::|.|...||.|:|::...::|.|:.:.|.|..:.:.|.|::.:.:...|    ..:|
  Rat   823 LYGTSVQSVRAVAEKGKHCILDVSGNAIKRLQIAQLYPISIFIKPKSMENIMEMNKR----LTDE 883

  Fly  1959 ELKDIIATARDMEARWGHLFDMIIINNDTERAYHQLLAEINSLEREPQWVPAQ 2011
            :.:.....|..:|..:...|..|:..:..|..|:|:...|........||||:
  Rat   884 QARKTFERAVRLEQEFTEHFTAIVQGDTLEDIYNQVKQIIEEQSGPYIWVPAK 936

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
sdt	NP_001033835.2	PDZ_signaling	<54..102	CDD:238492
		L27	1423..1466	CDD:295425	7/42 (17%)
		PDZ_signaling	1562..1640	CDD:238492	24/83 (29%)
		SH3_MPP5	1673..1734	CDD:212969	29/63 (46%)
		Guanylate_kin	1820..1994	CDD:279019	53/179 (30%)
		GuKc	1831..2002	CDD:214504	51/176 (29%)
Dlg1	XP_038943929.1	PDZ_signaling	224..308	CDD:238492	17/95 (18%)
		PDZ_signaling	317..403	CDD:238492	22/122 (18%)
		PDZ_assoc	404..465	CDD:402299	16/94 (17%)
		PDZ	463..547	CDD:214570	25/85 (29%)
		SH3_DLG1	582..648	CDD:212964	30/71 (42%)
		Guanylate_kin	748..926	CDD:395500	55/188 (29%)
		L27_1	2..62	CDD:401120
		MAGUK_N_PEST	106..223	CDD:402306	30/158 (19%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0194
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810