DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment sdt and Dlg2

DIOPT Version :9

Sequence 1:	NP_001033835.2	Gene:	sdt / 44861	FlyBaseID:	FBgn0261873	Length:	2020	Species:	Drosophila melanogaster
Sequence 2:	XP_006507830.1	Gene:	Dlg2 / 23859	MGIID:	1344351	Length:	1027	Species:	Mus musculus

Alignment Length:	1100	Identity:	247/1100 - (22%)
Similarity:	410/1100 - (37%)	Gaps:	288/1100 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly  1037 LNSSNSSMHTSS---SSSGHSSNIASATSSSSATSSSTVPDDLSLAPPGYEVSQQQQQQHLVATP 1098
            |:|...|:..||   |.||...|......:.....|....::.:....|    :...|...|..|
Mouse    88 LDSCRDSLQKSSEHASCSGPKENALYIEQNKENQCSENETEEKTCQNQG----KCPAQNCSVEAP 148

  Fly  1099 VTMLLPPMAKHRELPVDVP-DSFIEMVKTTPRYPPPAHLSSRG-SLLSNGSASTAHTTLSSMGVA 1161
            ..|.:....|:|....|.| |..:..:....|.|...|:|.:. |.:.|.......:.:|.:..:
Mouse   149 TWMPVHHCTKYRYQDEDGPHDHSLPRLTHEVRGPELVHVSEKNLSQIENVHGYVLQSHISPLKAS 213

  Fly  1162 PSPVTATAAAAASASAACATTAVAAAAVSGVADGDARRVADELNGNAKPVPPPRDHLRVEKDGRL 1226
            |:|:                          :.:.|.......:||.  .:....:.:.:|:....
Mouse   214 PAPI--------------------------IVNTDTLDTIPYVNGT--EIEYEFEEITLERGNSG 250

  Fly  1227 VNCSPA-----PQLPD-------RRAPGNASS--GSSGATTHPLQHQQI-------AQIVEPTLE 1270
            :..|.|     |.:.|       :..||.|::  |........|:..::       ::.||...|
Mouse   251 LGFSIAGGTDNPHIGDDPGIFITKIIPGGAAAEDGRLRVNDCILRVNEVDVSEVSHSKAVEALKE 315

  Fly  1271 QLDSIKKYQEQLRRRREEEERIAQQNEFLRNSLRGSRKLKALQDTATPGKAVAQQQQQATLATQV 1335
            ....::.|   :||||...|.:.:...|     :|.:.|         |.::|.
Mouse   316 AGSIVRLY---VRRRRPILETVVEIKLF-----KGPKGL---------GFSIAG----------- 352

  Fly  1336 VGVENEAYLPDEDQPQAEQ-IDGYGELIAALTRLQNQLSKSGLSTLAGRVSAAHSVL-----ASA 1394
             ||.|: ::|.::.....: |||                  |.:...||:.....:|     :..
Mouse   353 -GVGNQ-HIPGDNSIYVTKIIDG------------------GAAQKDGRLQVGDRLLMVNNYSLE 397

  Fly  1395 SVAHVLAARTAVLQRRRSRVSGPLHHSSLGLQKDIVELLTQSNTAAAIELGNLLTSHEMEGLLLA 1459
            .|.|                            ::.|.:|..::....:::|...|.:
Mouse   398 EVTH----------------------------EEAVAILKNTSDVVYLKVGKPTTIY-------- 426

  Fly  1460 HDRIANHTD--GTPSPTPTPTPAIG----AATGSTLS-------------SPVAGPKRNLG---M 1502
                  .||  |.|..|.:.:|.:.    :....||.             ||:  ||..||   .
Mouse   427 ------MTDPYGPPDITHSYSPPMENHLLSGNNGTLEYKTSLPPISPGRYSPI--PKHMLGEDDY 483

  Fly  1503 VVPPPVVPPPLAQRGAMPL-PRGESP----------PPVPMPPLATMPMSMPVNLPMSACFGTLN 1556
            ..||..|...:.:....|. ||..||          .|.|...|..:|.|   ::...:...|..
Mouse   484 TRPPEPVYSTVNKLCDKPASPRHYSPVECDKSFLLSTPYPHYHLGLLPDS---DMTSHSQHSTAT 545

  Fly  1557 DQ-----------NDNIRIIQIEKSTEPLGATV--RNEGEAVVIGRIVRGGAAEKSGLLHEGDEI 1608
            .|           ....|.:.:.|.:..||..:  ..:||.:.:..|:.||.|:.||.|..||:|
Mouse   546 RQPSVTLQRAISLEGEPRKVVLHKGSTGLGFNIVGGEDGEGIFVSFILAGGPADLSGELQRGDQI 610

  Fly  1609 LEVNGQELRGKTVNEVCALL-GAMQGTLTFLIVPAGSPPSVG------------VMGGTTGSQLA 1660
            |.|||.:|||.:..:..|.| ||.|   |..|:....|....            :|..:..|...
Mouse   611 LSVNGIDLRGASHEQAAAALKGAGQ---TVTIIAQYQPEDYARFEAKIHDLREQMMNHSMSSGSG 672

  Fly  1661 GLGGAHRDTAVLHVRAHFDYDPEDDLYIPCRELGISFQKGDVLHVISREDPNWWQAYR---EGEE 1722
            .|....:.:  |:|||.||||...|..:|.:  |:||:.||:||||:..|..||||.|   :|:.
Mouse   673 SLRTNQKRS--LYVRAMFDYDKSKDSGLPSQ--GLSFKYGDILHVINASDDEWWQARRVTLDGDS 733

  Fly  1723 DQTLAGLIPSQSFQHQRETMKLAIAE---EAGLARSRGKDGSGSKGATLLCARKGRKKKKKASSE 1784
            ::  .|:|||:....::|..:|...:   :.|:..|:|....              |:||.....
Mouse   734 EE--MGVIPSKRRVERKERARLKTVKFNAKPGVIDSKGSFND--------------KRKKSFIFS 782

  Fly  1785 AGYPLYATTAPDE---TDPEE-------------------ILTYEEVALYYPRATHKRPIVLIGP 1827
            ..:|.|......|   :|||:                   ||:||.|.  .....:.||::::||
Mouse   783 RKFPFYKNKEQSEQETSDPEQHVSSNASDSESSCRGQEDLILSYEPVT--RQEINYTRPVIILGP 845

  Fly  1828 PNIGRHELRQRLMAD-----SERFSAAVPHTSRARREGEVPGVDYHF-ITRQAFEADILARRFVE 1886
                   ::.|:..|     .::|.:.||||:|.:|:.||.|.|||| |:|:..|.||...:|:|
Mouse   846 -------MKDRINDDLISEFPDKFGSCVPHTTRPKRDYEVDGRDYHFVISREQMEKDIQEHKFIE 903

  Fly  1887 HGEYEKAYYGTSLEAIRTVVASGKICVLNLHPQSLKLLRASDLKPYVVLVAPPSLDKLRQKKLRN 1951
            .|:|....||||::::|.|...||.|:|::...::|.|:.:.|.|..:.:.|.||:.|.:...|
Mouse   904 AGQYNDNLYGTSVQSVRFVAERGKHCILDVSGNAIKRLQVAQLYPIAIFIKPKSLEPLMEMNKR- 967

  Fly  1952 GEPFKEEELKDIIATARDMEARWGHLFDMIIINNDTERAYHQLLAEINSLEREPQWVPAQ 2011
               ..||:.|.....|..:|..:|..|..|:..:..|..|:|....|........|:|::
Mouse   968 ---LTEEQAKKTYDRAIKLEQEFGEYFTAIVQGDTLEDIYNQCKLVIEEQSGPFIWIPSK 1024

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
sdt	NP_001033835.2	PDZ_signaling	<54..102	CDD:238492
		L27	1423..1466	CDD:295425	4/42 (10%)
		PDZ_signaling	1562..1640	CDD:238492	29/80 (36%)
		SH3_MPP5	1673..1734	CDD:212969	29/63 (46%)
		Guanylate_kin	1820..1994	CDD:279019	58/179 (32%)
		GuKc	1831..2002	CDD:214504	56/176 (32%)
Dlg2	XP_006507830.1	L27_1	4..63	CDD:370268
		MAGUK_N_PEST	158..240	CDD:371162	17/109 (16%)
		PDZ_signaling	241..325	CDD:238492	14/86 (16%)
		PDZ_signaling	334..419	CDD:238492	20/157 (13%)
		PDZ_assoc	421..488	CDD:371157	16/82 (20%)
		PDZ_signaling	562..640	CDD:238492	29/80 (36%)
		SH3_DLG2	677..750	CDD:212965	30/78 (38%)
		Guanylate_kin	836..1014	CDD:366206	60/188 (32%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0194
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810