DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment sdt and Mpp4

DIOPT Version :9

Sequence 1:	NP_001033835.2	Gene:	sdt / 44861	FlyBaseID:	FBgn0261873	Length:	2020	Species:	Drosophila melanogaster
Sequence 2:	NP_001158154.1	Gene:	Mpp4 / 227157	MGIID:	2386681	Length:	654	Species:	Mus musculus

Alignment Length:	739	Identity:	209/739 - (28%)
Similarity:	341/739 - (46%)	Gaps:	184/739 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly  1342 AYLPDEDQPQAEQIDGYGELIAALTRLQNQLS------KSGLSTLAGRVSAAHSVLASASVAHVL 1400
            |.|.:||:......|....|...|..|..:||      .:||..|       :.:|.|..:..:|
Mouse    27 AELTNEDRALPTPPDPENGLSGILRLLLQELSLFYSRDVNGLCLL-------YDLLHSPWLQALL 84

  Fly  1401 AARTAVLQRRRSRVSGPLHHSSLGLQKDIVELLTQSNTAAAI-ELGNLLTSHEMEGLLLAHDRIA 1464
            .....:.:.:..::.....|:.: |..:::|||.:::.:..| ||..:|.:...:.||.|||.:
Mouse    85 KVYDCLQRFKEKKLVPDTTHAQI-LACEVLELLPKASGSPEIQELRQVLQAPHCKALLSAHDTV- 147

  Fly  1465 NHTDGTPSPTPTPTPAIGAATGSTLSSPVAGPKRNLGMVVPPPVVPPPLAQRGAMPLPRGESPPP 1529
                                                             ||:...||
Mouse   148 -------------------------------------------------AQKDFEPL-------- 155

  Fly  1530 VPMPPLATMPMSMPVNLPMSACFGTLNDQNDNIRIIQIEKSTEPLGATVRNE---GEAVVIGRIV 1591
              :|||       |.|:|         |..:.:||:.:.|:.:|||||::..   |: :::.|::
Mouse   156 --LPPL-------PDNIP---------DSEEAMRIVCLVKNQQPLGATIKRHEITGD-ILVARVI 201

  Fly  1592 RGGAAEKSGLLHEGDEILEVNGQELRGKTVNEVCALLGAMQGTLTFLIVPAGSPPSVGVMGGTTG 1656
            .||..|:||||:.||:::||||..:.|....:|..:|....||:.|.::|..:||        ..
Mouse   202 HGGLVERSGLLYAGDKLVEVNGVSVEGLDPEQVIHILAMSCGTIMFKVIPVSAPP--------VS 258

  Fly  1657 SQLAGLGGAHRDTAVLHVRAHFDYDPEDDLYIPCRELGISFQKGDVLHVISREDPNWWQAYREGE 1721
            ||           .:::|||..||.|::|..|||.:.|:.|.|||:|.::.:.|..||||.:  .
Mouse   259 SQ-----------KMVYVRAMIDYWPQEDPDIPCMDAGLPFLKGDILQIVDQNDALWWQARK--I 310

  Fly  1722 EDQTL-AGLIPSQSF--QHQRE---------------TMKLAIAEEAG----------------- 1751
            .|.|: ||||||...  :.|||               |..|::.||..
Mouse   311 SDLTICAGLIPSNHLLKRKQREFWWSQPYQPHTCLKSTRALSMEEEDSMKIDEKCVEADEETFES 375

  Fly  1752 --LARSRGK---DG-----SGSKGATLLCARKGRKKKKKASSEAGYPLY-ATTAPDETDPEEILT 1805
              ||.::.:   ||     :|.:.:..||.||....:..||.......| |..||
Mouse   376 EELAEAKDEFVGDGQKFFIAGFRRSMRLCRRKSHFSQLHASLCCSCSCYSAVGAP---------- 430

  Fly  1806 YEEVALYYPRATHK-RPIVLIGPPNIGRHELRQRLM-ADSERFSAAVPHTSRARREGEVPGVDYH 1868
            ||||..|..:...| |.|||:||..:|.:|||::|: .:...|.:|||||:|..:..|:.|.:||
Mouse   431 YEEVVRYQRQPADKHRLIVLVGPSGVGVNELRRQLIGCNPSCFQSAVPHTTRFPKSYEMDGREYH 495

  Fly  1869 FITRQAFEADILARRFVEHGEYEKAYYGTSLEAIRTVVASGKICVLNLHPQSLKLLRASDLKPYV 1933
            :::|:.||:.:...:.:|:|||:...||||:.|:..|:..||||:::|.||.::..|..||||||
Mouse   496 YVSRETFESLMYGHKMLEYGEYKGHLYGTSVNAVHAVLDEGKICIMDLEPQDIQSARTRDLKPYV 560

  Fly  1934 VLVAPPSLDKLRQKKLRNGE---------PFKEEELKDIIATARDMEARWGHLFDMIIINNDTER 1989
            :.:.||:...:|..: :|.:         .||:|:|:::...|:.||:::|..||.:|:|::.:.
Mouse   561 IFIKPPNTSSMRHSR-KNAKITTDYYVDMKFKDEDLQEMEELAQKMESQFGQFFDHVIVNDNLQD 624

  Fly  1990 AYHQLLAEINSLEREPQWVPAQWV 2013
            |..|||:.|...:.|.||||..||
Mouse   625 ACGQLLSAIQKAQEELQWVPEAWV 648

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
sdt	NP_001033835.2	PDZ_signaling	<54..102	CDD:238492
		L27	1423..1466	CDD:295425	13/43 (30%)
		PDZ_signaling	1562..1640	CDD:238492	29/80 (36%)
		SH3_MPP5	1673..1734	CDD:212969	29/61 (48%)
		Guanylate_kin	1820..1994	CDD:279019	66/183 (36%)
		GuKc	1831..2002	CDD:214504	64/180 (36%)
Mpp4	NP_001158154.1	L27	<66..100	CDD:197794	6/40 (15%)
		L27	108..154	CDD:280918	15/95 (16%)
		PDZ_signaling	171..250	CDD:238492	29/79 (37%)
		SH3_MPP4	264..324	CDD:212967	29/61 (48%)
		Guanylate_kin	446..636	CDD:279019	70/190 (37%)
		GuKc	454..637	CDD:214504	64/183 (35%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0194
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810