DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment sdt and dlg-1

DIOPT Version :9

Sequence 1:	NP_001033835.2	Gene:	sdt / 44861	FlyBaseID:	FBgn0261873	Length:	2020	Species:	Drosophila melanogaster
Sequence 2:	NP_001024431.1	Gene:	dlg-1 / 180819	WormBaseID:	WBGene00001006	Length:	967	Species:	Caenorhabditis elegans

Alignment Length:	1270	Identity:	256/1270 - (20%)
Similarity:	429/1270 - (33%)	Gaps:	428/1270 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly   836 NQKQQNKLEQI----------------ENYENCLQSERNEQHEQQFEQQK--------QHQATTA 876
            |::.:..||::                :.||..|.|||....|:..|.::        .|...:.
Worm    28 NEELRTNLERVITTFKSNLMHSLLDIHDLYEQTLLSERKSDAEKNMEVRRVIERLEGGPHSYNSR 92

  Fly   877 MAATQVAQQQTPSHKLQAT--LSSD---------PNGNSNSNNNSHIVGISSSSSSNNSSITDDF 930
            .|||    ..|.::.|.:|  |.||         .||....|...:.:|....||..|||.|
Worm    93 PAAT----TSTSNYNLSSTTPLISDLRDRGGFSYLNGGGLGNGLGNGLGNGLLSSPYNSSST--- 150

  Fly   931 LCVVDGLYQGRKDTASPSSSAFDEVMSKHTLDSFGSIAYRHLHQQHQATSNGNSSSNTSNTNSNT 995
                                                   .:||::.:.||:..:...|:....:|
Worm   151 ---------------------------------------HYLHERQRQTSHDGTWRETTTRTVDT 176

  Fly   996 NSNTNSNSNTNGNTSNNTAVSTKTATVTKTGVSSSNSNSNSL-NSSNSSMHTS---SSSSGHSSN 1056
            .|                  ..:...|..|||...:.....| |......||.   |.:.|....
Worm   177 PS------------------GLERRVVEHTGVIDDHGRKWELENIVLEKGHTGLGFSITGGMDQP 223

  Fly  1057 IASATSSSSATSSSTVPDDLSLAPPGYEVSQQQQQQHLVATPVTMLLPPMAKHRELPVDVPDSFI 1121
            .....:|...|         ::...|..::..:.:::.:.|.|........|| |:.|:...|..
Worm   224 TEDGDTSIYVT---------NIIEGGAALADGRMRKNDIITAVNNTNCENVKH-EVAVNALKSSG 278

  Fly  1122 EMVK-TTPRYPPPAHLSSRGSLLSNGSASTAHTTLSSMGVAPSPVTATAAAAASASAACATTAVA 1185
            .:|. :..|....|.|...|:.  .||.|...:     ||.||
Worm   279 NVVSLSLKRRKDEAFLPIGGNF--GGSTSYLRS-----GVTPS---------------------- 314

  Fly  1186 AAAVSGVADGDARRVADELNGNAKPVPPPRDHLRVEKDGRLVNCSPAPQLPDRRAPGNASSGSSG 1250
                  |:.|:.:......:....|.|||
Worm   315 ------VSAGNLQHAIHSPSAPIHPPPPP------------------------------------ 337

  Fly  1251 ATTHPLQHQQIAQIVEPTLEQLDSIKKYQEQLRRRREEEERIAQQNEFLRNSLRGSRKLKALQDT 1315
                |:.|..::|:         |:.:|            |..:.|..:.:.::|:|.|
Worm   338 ----PVHHGSLSQL---------SVGQY------------RSTRPNTSVIDLVKGARGL------ 371

  Fly  1316 ATPGKAVAQQQQQATLATQVVGVENEAYLPDEDQPQAEQIDGYGELIAALTRLQNQLSKSGLSTL 1380
               |.::|..|..                        |.:.|..::..      .::.:.|.:.|
Worm   372 ---GFSIAGGQGN------------------------EHVKGDTDIYV------TKIIEEGAAEL 403

  Fly  1381 AGRVSAAHSVLASASVAHVLAARTAVLQRRRSRVSGPLHHSSLGLQKDI---VELLTQSNTAAAI 1442
            .||:.....:|   .|.|.....|.             |.:::.:.|:.   |.||.|..|.|..
Worm   404 DGRLRVGDKIL---EVDHHSLINTT-------------HENAVNVLKNTGNRVRLLIQQGTGAIF 452

  Fly  1443 ELGNLLTSHEMEGLLLAHDRIANHTDGTPSPTPTPTPAIGAATGSTLSSPVAGPKRNLGMVVPPP 1507
                                    .|.........||.:..::....:....|.:.:|..
Worm   453 ------------------------NDSASQQFMPTTPILRPSSVQDYNRSQMGSQSHLSY----- 488

  Fly  1508 VVPPPLAQRGAMPLPRGESPPPVPMPPLATMPMSM-PVNLPMSACFGTLNDQNDNIRIIQIEKST 1571
                     |.               ||.|...|. |:.:|:..            |.:|:.|..
Worm   489 ---------GG---------------PLNTSYSSQAPIAIPLEP------------RPVQLVKGQ 517

  Fly  1572 EPLGATV--RNEGEAVVIGRIVRGGAAEKSGLLHEGDEILEVNGQELRGKTVNEVCALLGAMQGT 1634
            ..||..:  ..:.|.:.|..::.||.|:.||.:..||.:|||||..||..|..|....|.
Worm   518 NGLGFNIVGGEDNEPIYISFVLPGGVADLSGNVKTGDVLLEVNGVVLRNATHKEAAEALR----- 577

  Fly  1635 LTFLIVPAGSPPSVGVMGGTTGSQL---------------AGLGGAHRDTAVLHVRAHFDYDP-E 1683
                  .||:|..:.:.......|:               :.:|...|.:.  :|||.||||| .
Worm   578 ------NAGNPVYLTLQYRPQEYQIFESKIEKLRNDVIAQSRMGTLSRKSE--YVRALFDYDPSR 634

  Fly  1684 DDLYIPCRELGISFQKGDVLHVISREDPNWWQA---YREGEEDQTLAGLIPSQSFQHQRETMKLA 1745
            ::...|.|.:|  |..||:||:|:..|..||.|   :..|||  |..|:|||:....:||.::..
Worm   635 ENSVAPHRSMG--FNYGDILHIINSSDDEWWTARKVHENGEE--TAEGVIPSKKRVEKRERLRRK 695

  Fly  1746 IAEEAGLARSRGKDGSGSKGATLLCARKGRKKKKKASSEAGYPLYATT--------APDETDPEE 1802
            .......::|.|::.|    .|.|..|:|.:.:...|.:  :|...:|        .......|.
Worm   696 QVNFNSGSQSLGRNSS----TTGLENRRGSRSQLSFSRK--FPFVKSTDRLNDLNEESSNVAEEP 754

  Fly  1803 ILTY---EEVALYYPRATHKRPIVLIGPPNIGRHELRQRL-----MADSERFSAAVPHTSRARRE 1859
            :.:|   |:.|:.|     .||::::|       .|:.|:     ..|..:||:.||||||..||
Worm   755 VWSYQAVEQQAINY-----VRPVIILG-------ALKDRINDELVNRDPSKFSSCVPHTSRPPRE 807

  Fly  1860 GEVPGVDYHFITRQAFEADILARRFVEHGEYEKAYYGTSLEAIRTVVASGKICVLNLHPQSLKLL 1924
            |||.|.||:|:.:...|.|:....|:|.|:::...||||::::|.|...|:.|:|::...:::.|
Worm   808 GEVNGRDYYFVNKHNMEEDVKNNLFIEAGQFQNNLYGTSIQSVRDVANQGRHCILDVSGNAIRRL 872

  Fly  1925 RA-SDLKPYVVLVAPPS------LDKLRQKKLRNGEPFKEEELKDIIATARDMEARWGHLFDMII 1982
            :: ::::|..:.:.|.|      ||.......::......||.:...:....:|..:|.||...|
Worm   873 QSNANIQPISIFIKPSSAQQILELDSQLATNRQDDRAMSGEEAQAQYSRCHRIEQTFGDLFTQEI 937

  Fly  1983 IN----NDTERAYHQLLAEINS-LERE---PQWVP 2009
            .|    ||       :|:::.| :.||   |.|||
Worm   938 SNVHSAND-------VLSKVYSIISRESQTPIWVP 965

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
sdt	NP_001033835.2	PDZ_signaling	<54..102	CDD:238492
		L27	1423..1466	CDD:295425	7/45 (16%)
		PDZ_signaling	1562..1640	CDD:238492	24/79 (30%)
		SH3_MPP5	1673..1734	CDD:212969	29/64 (45%)
		Guanylate_kin	1820..1994	CDD:279019	53/189 (28%)
		GuKc	1831..2002	CDD:214504	52/187 (28%)
dlg-1	NP_001024431.1	L27_1	7..63	CDD:312556	6/34 (18%)
		PDZ	199..289	CDD:214570	18/99 (18%)
		PDZ_signaling	361..445	CDD:238492	21/138 (15%)
		PDZ	507..591	CDD:214570	27/106 (25%)
		SH3_DLG-like	623..684	CDD:212795	29/64 (45%)
		GuKc	776..944	CDD:214504	49/174 (28%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910