DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment sdt and Mpp1

DIOPT Version :9

Sequence 1:	NP_001033835.2	Gene:	sdt / 44861	FlyBaseID:	FBgn0261873	Length:	2020	Species:	Drosophila melanogaster
Sequence 2:	NP_032647.1	Gene:	Mpp1 / 17524	MGIID:	105941	Length:	466	Species:	Mus musculus

Alignment Length:	456	Identity:	137/456 - (30%)
Similarity:	231/456 - (50%)	Gaps:	61/456 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly  1562 IRIIQIEKST-EPLGATVR-NEGEAVVIGRIVRGGAAEKSGLLHEGDEILEVNGQELRGKTVNEV 1624
            :|:||.||.| ||:|.|:: ||.::..:.||:.||...:.|.||.||||||:||..:...:|:::
Mouse    69 VRLIQFEKITEEPMGITLKLNEKQSCTVARILHGGMIHRQGSLHVGDEILEINGTNVTNHSVDQL 133

  Fly  1625 CALLGAMQGTLTFLIVPAGSPPSVGVMGGTTGSQLAGLGGAHRDTAVLHVRAHFDYDPEDDLYIP 1689
            ...:...:|.::..::            ....|:|..|        .:.:||.|||||:.|..||
Mouse   134 QKAMKETKGMISLKVI------------ANQQSRLPAL--------QMFMRAQFDYDPQKDNLIP 178

  Fly  1690 CRELGISFQKGDVLHVISREDPNWWQAYREGEEDQTLAGLIPSQSFQHQRETMKLAIAEEAGLAR 1754
            |:|.|:.|..||::.:|:::|.||||...||...:: ||||||...|..|      :|..|..|.
Mouse   179 CKEAGLKFVTGDIIQIINKDDSNWWQGRVEGSSKES-AGLIPSPELQEWR------VASVAHSAP 236

  Fly  1755 SRGKDGSGSKGATLLCARKGRKKKKKASSEAGYPLYATTAPDETDPEEILTYEEVALYYPRATHK 1819
            |....          |:..|:|||.|..       |........|..::::|||| :..| |..:
Mouse   237 SEAPS----------CSPFGKKKKCKDK-------YLAKHSSIFDQLDVVSYEEV-VRLP-AFKR 282

  Fly  1820 RPIVLIGPPNIGRHELRQRLMA-DSERFSAAVPHTSRARREGEVPGVDYHFITRQAFEADILARR 1883
            :.:||||...:||..::..|:: :.|:|:...|:|:|..::.|..|.:||||:.:....:|.|..
Mouse   283 KTLVLIGASGVGRSHIKNGLLSHNPEKFAYPAPYTTRPPKKSEEDGKEYHFISTEEMTKNISANE 347

  Fly  1884 FVEHGEYEKAYYGTSLEAIRTVVASGKICVLNLHPQSLKLLRASDLKPYVVLVAPPSLDKLRQKK 1948
            |:|.|.|:...:||..|.:..:....||.:|::.||:||.:|.::|.|::|.:||
Mouse   348 FLEFGSYQGNMFGTKFETVHQIHKQDKIAILDIEPQTLKTVRTAELSPFIVFIAP---------- 402

  Fly  1949 LRNGEPFKEEELKDIIATARDMEARWGHLFDMIIINNDTERAYHQLLAEINSLEREPQWVPAQWV 2013
              ..:..:.|.|:.:...:..:.:::.|.||:.::||..:....:|....:.....|||||..||
Mouse   403 --TDQGTQTEALQQLQKDSEAIRSQYAHYFDLSLVNNSVDETLKKLQEAFDQACSSPQWVPVSWV 465

  Fly  2014 H 2014
            :
Mouse   466 Y 466

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
sdt	NP_001033835.2	PDZ_signaling	<54..102	CDD:238492
		L27	1423..1466	CDD:295425
		PDZ_signaling	1562..1640	CDD:238492	29/79 (37%)
		SH3_MPP5	1673..1734	CDD:212969	30/60 (50%)
		Guanylate_kin	1820..1994	CDD:279019	47/174 (27%)
		GuKc	1831..2002	CDD:214504	44/171 (26%)
Mpp1	NP_032647.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	29..65
		PDZ	71..149	CDD:278991	28/77 (36%)
		SH3_MPP1	162..223	CDD:213013	30/61 (49%)
		Interaction with PALS1. /evidence=ECO:0000250	268..466		60/211 (28%)
		Guanylate_kin	281..453	CDD:279019	48/183 (26%)
		GuKc	291..454	CDD:214504	44/174 (25%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0194
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810