DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment sdt and DLG4

DIOPT Version :9

Sequence 1:	NP_001033835.2	Gene:	sdt / 44861	FlyBaseID:	FBgn0261873	Length:	2020	Species:	Drosophila melanogaster
Sequence 2:	XP_011522001.1	Gene:	DLG4 / 1742	HGNCID:	2903	Length:	797	Species:	Homo sapiens

Alignment Length:	1015	Identity:	231/1015 - (22%)
Similarity:	368/1015 - (36%)	Gaps:	331/1015 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly  1094 LVATPVTMLLPPM--AKHREL---PVDVPDSFIEMVKTTPRY-------PP----PAHLSSRG-- 1140
            |:|.|:....||:  ..|.:|   .:|:.|.:...:..:.:|       ||    ||||.::.
Human    14 LLAPPLLRWAPPLLTVLHSDLFQALLDILDYYEASLSESQKYRYQDEDTPPLEHSPAHLPNQVNA 78

  Fly  1141 -----------SLLSNGSASTAHTTLSSMGVAPSPVTATAAAAASASAACATTAVAAAAVSG--- 1191
                       |.|..|.....|..||.......||...           ..|..|...|:|
Human    79 PELVHVAERNLSHLEAGHGVVGHAHLSPFKANSPPVIVN-----------TDTLEAPGYVNGTEG 132

  Fly  1192 -------------------VADG-DARRVADE--------LNGNAKPVPPPRDHLRVEKDGRL-V 1227
                               :|.| |...:.|:        :.|.|           ..:|||| |
Human   133 EMEYEEITLERGNSGLGFSIAGGTDNPHIGDDPSIFITKIIPGGA-----------AAQDGRLRV 186

  Fly  1228 NCSP--APQLPDRRAPGNASSGSSGATTHPLQHQQIAQIVEPTLEQLDSIKKYQEQLRRRREEEE 1290
            |.|.  ..::..|....:|:                   ||...|....::.|   :.||:...|
Human   187 NDSILFVNEVDVREVTHSAA-------------------VEALKEAGSIVRLY---VMRRKPPAE 229

  Fly  1291 RIAQQNEFLRNSLRGSRKLKALQDTATPGKAVAQQQQQATLATQVVGVENEAYLPDEDQPQAEQI 1355
            ::.:              :|.::.....|.::|.            ||.|: ::|.::.....:|
Human   230 KVME--------------IKLIKGPKGLGFSIAG------------GVGNQ-HIPGDNSIYVTKI 267

  Fly  1356 DGYGELIAALTRLQNQLSKSGLSTLAGRVSAAHSVLASASVAHVLAARTAVLQRRRSRVSGPLHH 1420
                             .:.|.:...||:.....:||..||.                :...:|.
Human   268 -----------------IEGGAAHKDGRLQIGDKILAVNSVG----------------LEDVMHE 299

  Fly  1421 SSLGLQK---DIVELLTQSNTAAAIELG----NLLTSHEMEGLLLAH-DRIANHTD--GTPSPTP 1475
            .::...|   |:|.|.....:.|.:...    ::.||:..      | |...:|:.  ||..||.
Human   300 DAVAALKNTYDVVYLKVAKPSNAYLSDSYAPPDITTSYSQ------HLDNEISHSSYLGTDYPTA 358

  Fly  1476 -TPTPAIGAATGSTLSSPVAGPKRNLGMVVPPPVVPPPLAQRGAMPLPRGESPPPVPMPPLATMP 1539
             |||                .|:|.      .||....|.:.            .:|..|
Human   359 MTPT----------------SPRRY------SPVAKDLLGEE------------DIPREP----- 384

  Fly  1540 MSMPVNLPMSACFGTLNDQNDNIRIIQIEKSTEPLGATV--RNEGEAVVIGRIVRGGAAEKSGLL 1602
                                   |.|.|.:.:..||..:  ..:||.:.|..|:.||.|:.||.|
Human   385 -----------------------RRIVIHRGSTGLGFNIVGGEDGEGIFISFILAGGPADLSGEL 426

  Fly  1603 HEGDEILEVNGQELRGKTVNEVC-ALLGAMQGTLTFLIVPAGSPPSVG------------VMGGT 1654
            .:||:||.|||.:||..:..:.. ||..|.|   |..|:....|....            :|..:
Human   427 RKGDQILSVNGVDLRNASHEQAAIALKNAGQ---TVTIIAQYKPEEYSRFEAKIHDLREQLMNSS 488

  Fly  1655 TGSQLAGLGGAHRDTAVLHVRAHFDYDPEDDLYIPCREL--GISFQKGDVLHVISREDPNWWQAY 1717
            .||..|.|  ........::||.||||...|    |..|  .:||:.|||||||...|..||||.
Human   489 LGSGTASL--RSNPKRGFYIRALFDYDKTKD----CGFLSQALSFRFGDVLHVIDASDEEWWQAR 547

  Fly  1718 REGEEDQT-LAGLIPSQSFQHQRETMKLAIAEEAGLARSRGKDGSGSKGATLLCARKGRKKKKKA 1781
            |...:.:| ..|.|||:....:||..:|           :.||...|.|:      :||:
Human   548 RVHSDSETDDIGFIPSKRRVERREWSRL-----------KAKDWGSSSGS------QGRE----- 590

  Fly  1782 SSEAGYPLYATTAPDETDPEEILTYEEVA---LYYPRATHKRPIVLIGPPNIGRHELRQRLMAD- 1842
                               :.:|:||.|.   ::|     .|||:::||.   :......|:::
Human   591 -------------------DSVLSYETVTQMEVHY-----ARPIIILGPT---KDRANDDLLSEF 628

  Fly  1843 SERFSAAVPHTSRARREGEVPGVDYHFI-TRQAFEADILARRFVEHGEYEKAYYGTSLEAIRTVV 1906
            .::|.:.||||:|.:||.|:.|.||||: :|:..|.||.|.:|:|.|:|....||||::::|.|.
Human   629 PDKFGSCVPHTTRPKREYEIDGRDYHFVSSREKMEKDIQAHKFIEAGQYNSHLYGTSVQSVREVA 693

  Fly  1907 ASGKICVLNLHPQSLKLLRASDLKPYVVLVAPPSLDKLRQKKLRNGEPFKEEELKDIIATARDME 1971
            ..||.|:|::...:::.|:|:.|.|..:.:.|.||:.:    |...:...||:.:.....|..:|
Human   694 EQGKHCILDVSANAVRRLQAAHLHPIAIFIRPRSLENV----LEINKRITEEQARKAFDRATKLE 754

  Fly  1972 ARWGHLFDMIIINNDTERAYHQLLAEINSLEREPQWVPAQ 2011
            ..:...|..|:..:..|..||::...|..|.....||||:
Human   755 QEFTECFSAIVEGDSFEEIYHKVKRVIEDLSGPYIWVPAR 794

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
sdt	NP_001033835.2	PDZ_signaling	<54..102	CDD:238492
		L27	1423..1466	CDD:295425	9/50 (18%)
		PDZ_signaling	1562..1640	CDD:238492	29/80 (36%)
		SH3_MPP5	1673..1734	CDD:212969	29/63 (46%)
		Guanylate_kin	1820..1994	CDD:279019	56/175 (32%)
		GuKc	1831..2002	CDD:214504	52/172 (30%)
DLG4	XP_011522001.1	L27	<26..49	CDD:413432	4/22 (18%)
		MAGUK_N_PEST	54..137	CDD:402306	19/93 (20%)
		PDZ	138..222	CDD:395476	19/116 (16%)
		PDZ	233..317	CDD:395476	20/143 (14%)
		PDZ_assoc	318..385	CDD:402299	20/134 (15%)
		PDZ	383..467	CDD:214570	31/114 (27%)
		SH3_DLG4	503..568	CDD:212963	29/68 (43%)
		Guanylate_kin	606..784	CDD:395500	58/189 (31%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0194
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810