DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment sdt and Card14

DIOPT Version :9

Sequence 1:	NP_001033835.2	Gene:	sdt / 44861	FlyBaseID:	FBgn0261873	Length:	2020	Species:	Drosophila melanogaster
Sequence 2:	XP_006532429.1	Gene:	Card14 / 170720	MGIID:	2386258	Length:	1029	Species:	Mus musculus

Alignment Length:	875	Identity:	172/875 - (19%)
Similarity:	289/875 - (33%)	Gaps:	306/875 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly  1254 HPLQHQ--------QIAQIV--------EPTLEQLDSIKKYQEQLRRRREEEERIAQ------QN 1296
            |.||.:        |.|.:|        |.:|:...:::...|:|.|.:||.|::..      :.
Mouse   220 HSLQEELYLVKQELQRASLVSSCERESRERSLKMASNLEPQGEELNRLKEENEKLRSMTFSLVEK 284

  Fly  1297 EFLRNSLRGSRKLK--------ALQDTATPGKAVAQQQQQATLATQVVGVENEAYLPDEDQPQAE 1353
            :.|..||..:|:.|        :|::     :|||.::||            :.|..:::|..
Mouse   285 DILEQSLDEARESKQELVDRIHSLRE-----RAVAAERQQ------------KQYWEEKEQTL-- 330

  Fly  1354 QIDGYGELIAALTRLQNQLSKSGLSTLAGRVSAAHSVLASASVAHVLAARTAVLQRRR-----SR 1413
                   |....|::..:|.|..::.|.|:|                    |.||:.|     :|
Mouse   331 -------LQFRKTQVDCELYKEKMTMLQGQV--------------------AELQKERDQAYTAR 368

  Fly  1414 VSGPLHHSSLGLQKDIVELLTQSNTAAAIELGNLLTSHEMEGLLLAHDRIANHTDGTPSPTPTPT 1478
            ....:..|...::||.:.......|....||...|...:.|
Mouse   369 DRAQMEISQRLVEKDALRRRVFELTEQVCELRTQLRRLQAE------------------------ 409

  Fly  1479 PAIGAATGSTLSSPVAGPKRNLG-----------MVVPPPVVPP--------------------P 1512
                 |.|        |||:..|           :|....|.||                    .
Mouse   410 -----APG--------GPKQEAGARELCLRGKQRLVRMHAVCPPDDSDCSLLSSTESRLWWDLNS 461

  Fly  1513 LAQRGAMPLPRGESPPPVPMPPLATM--------------PMSMPVNLPMSACFGTLNDQNDNIR 1563
            .:.|..|...|..|    ||||....              .:|.|..|.|.....|::|.:.::.
Mouse   462 TSSREQMDSFRSSS----PMPPSQQSLYKRVAEDFLEDPESLSFPEVLEMRLQGATVDDTDTDLE 522

  Fly  1564 IIQIE-----KSTEPLGATVR--NEGEAV---------VIGRIVRGGAAEKSGLLHEGDEILE-- 1610
            ...|:     ::.:.|..:.|  |..|.:         |..|..|...::.:.|..:||.:||
Mouse   523 FEMIDGADLSQTEDSLQGSSRSLNVSERLCLPAHSSVPVRRRPARKILSQVTVLAFQGDALLEQI 587

  Fly  1611 -VNGQELRGKTVNEVCALLGAMQ-----GTLTFLIVPAGSPPSV-GVMGGTTGSQLAGLGGAHRD 1668
             |.|..|.|..::.|.....|.:     ||...::....:.||: ..:..||..|..||......
Mouse   588 GVIGGNLTGIFIHRVTPGSAADEMALRPGTQIMMVDYKPTKPSLRATLENTTLEQAVGLLRRVNG 652

  Fly  1669 TAVLHVRAHF--------DYDPE-----DDLYIPCRELGISFQKG----------DVLHVISR-- 1708
            :..|.|:.:.        |.|.:     |..||   .:.::.|:|          |:|||...
Mouse   653 SCYLSVKINTEGYKNLIQDLDAKVVTSGDSFYI---RVNLAMQRGGDGELQTHCNDILHVTDTMF 714

  Fly  1709 EDPNWWQAYREGE---EDQTLAGLIPSQSFQHQRE--------TMKLAIAEEAG----------- 1751
            :..:.|.|:....   :|.. .|.||:.| |.|::        |.:..:..:.|
Mouse   715 QGRSCWHAHHVNPYTMKDME-PGTIPNYS-QAQQQLLALIQDMTQRCTVPRKVGHLVLLGHRAPF 777

  Fly  1752 -----LARSRGKDG--------SGSKGATLLCARKGRKKKKKASSEAGYPLYATTAPDETDPEEI 1803
                 |:.|:...|        |..|.|.........:.:..:..|.|.|.....:      |..
Mouse   778 TLSTHLSLSKPPGGPQKLVRIVSVDKAAVSPLTSSFDQSQWDSGKEEGGPSVCFWS------ESC 836

  Fly  1804 LTYEEVALYYP-RATHKRPIVLIGPPNIGRHE-----LRQRLMADSERFSAAVPHTSRARR---- 1858
            .|.....|.:| |....||::.: |..:||..     |.|.....|..:.:...:.:.::|
Mouse   837 FTLAPYTLVHPHRPARPRPVLFV-PRLVGRILGKKLCLLQGFKQCSAEYLSQEEYATWSQRGDII 900

  Fly  1859 -EGEVPGVDYHFITRQAFEADILARRFVEHGEYEKAYYGTSLEAIRTVVASGKICVLNLHPQSLK 1922
             |||..| |:|:|||.|.|                     ||..:.|      ..:|::...|::
Mouse   901 QEGESIG-DHHWITRHAVE---------------------SLMNMST------HALLDVRLDSVR 937

  Fly  1923 LLRASDLKPYVVLVAPPSLDKLRQKKLRNG 1952
            :|...|:.|.::.|   |:::...||||.|
Mouse   938 VLHRMDMFPIIIHV---SVNEKTAKKLRKG 964

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
sdt	NP_001033835.2	PDZ_signaling	<54..102	CDD:238492
		L27	1423..1466	CDD:295425	7/42 (17%)
		PDZ_signaling	1562..1640	CDD:238492	21/101 (21%)
		SH3_MPP5	1673..1734	CDD:212969	18/88 (20%)
		Guanylate_kin	1820..1994	CDD:279019	35/143 (24%)
		GuKc	1831..2002	CDD:214504	32/132 (24%)
Card14	XP_006532429.1	DD	19..104	CDD:387368
		Smc	<132..410	CDD:224117	47/264 (18%)
		PDZ_signaling	587..659	CDD:238492	16/71 (23%)
		SH3	684..745	CDD:388381	16/65 (25%)
		NK	<884..1008	CDD:388413	27/112 (24%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0194
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900