DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment sdt and Guk1

DIOPT Version :9

Sequence 1:	NP_001033835.2	Gene:	sdt / 44861	FlyBaseID:	FBgn0261873	Length:	2020	Species:	Drosophila melanogaster
Sequence 2:	NP_032219.2	Gene:	Guk1 / 14923	MGIID:	95871	Length:	219	Species:	Mus musculus

Alignment Length:	185	Identity:	81/185 - (43%)
Similarity:	115/185 - (62%)	Gaps:	9/185 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly  1820 RPIVLIGPPNIGRHELRQRLMAD-SERFSAAVPHTSRARREGEVPGVDYHFITRQAFEADILARR 1883
            ||:||.||...|:..|.::|..: |..|..:|.||:|..|.||..|.||:|:||:..:.||.|..
Mouse    26 RPVVLSGPSGAGKSTLLKKLFQEHSSIFGFSVSHTTRNPRPGEEDGKDYYFVTREMMQRDIAAGD 90

  Fly  1884 FVEHGEYEKAYYGTSLEAIRTVVASGKICVLNLHPQSLKLLRASDLKPYVVLVAPPSLDKLRQK- 1947
            |:||.|:....||||.||:|.|.|..:||||::..|.::.::.:||.|..:.|.|||||.|.|:
Mouse    91 FIEHAEFSGNLYGTSKEAVRAVQAMNRICVLDVDLQGVRSIKKTDLCPIYIFVQPPSLDVLEQRL 155

  Fly  1948 KLRNGEPFKEEELKDIIATAR-DME-ARWGHLFDMIIINNDTERAY---HQLLAE 1997
            :|||.|  .||.|...:|.|| ||| ::...|||::|||:|.::||   .|.|:|
Mouse   156 RLRNTE--TEESLAKRLAAARTDMESSKEPGLFDLVIINDDLDKAYATLKQALSE 208

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
sdt	NP_001033835.2	PDZ_signaling	<54..102	CDD:238492
		L27	1423..1466	CDD:295425
		PDZ_signaling	1562..1640	CDD:238492
		SH3_MPP5	1673..1734	CDD:212969
		Guanylate_kin	1820..1994	CDD:279019	78/180 (43%)
		GuKc	1831..2002	CDD:214504	75/174 (43%)
Guk1	NP_032219.2	Guanylate_kin	24..209	CDD:279019	81/185 (44%)
Guk1	NP_032219.2	guanyl_kin	26..208	CDD:213788	80/183 (44%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0194
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810