DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment sdt and Cask

DIOPT Version :9

Sequence 1:	NP_001033835.2	Gene:	sdt / 44861	FlyBaseID:	FBgn0261873	Length:	2020	Species:	Drosophila melanogaster
Sequence 2:	XP_011245733.1	Gene:	Cask / 12361	MGIID:	1309489	Length:	972	Species:	Mus musculus

Alignment Length:	864	Identity:	216/864 - (25%)
Similarity:	351/864 - (40%)	Gaps:	238/864 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly  1254 HPLQHQQIAQIVEP------TLEQLDSIKKYQEQLRRRREEEERIA------QQNEFLRNSLRGS 1306
            :|.|...|::..:.      .|:..:.|..|:.......:|.:|.|      :..|.|| .....
Mouse   244 NPRQWSHISESAKDLVRRMLMLDPAERITVYEALNHPWLKERDRYAYKIHLPETVEQLR-KFNAR 307

  Fly  1307 RKLKALQDTATPGKAVAQQQQQATLATQVVGVENEAY------LPD--ED----------QPQAE 1353
            ||||.                 |.||.......|..|      |||  ||          :..::
Mouse   308 RKLKG-----------------AVLAAVSSHKFNSFYGDPPEELPDFSEDPTSSGLLAAERAVSQ 355

  Fly  1354 QIDGYGELIAALTRLQNQLSKSGLSTLAGRVSAAHSVLASASVAHVLAARTAVLQRRRSRVSGPL 1418
            .:|...| |.|||    ..|:..|..|       |||.....:..:|.....:..:...::..|
Mouse   356 VLDSLEE-IHALT----DCSEKDLDFL-------HSVFQDQHLHTLLDLYDKINTKSSPQIRNP- 407

  Fly  1419 HHSSLGLQKDIVELLT---QSNTAAAIELGNLLTSHEMEGLLLAHDRIAN--HTDGTPSPTPTPT 1478
            ...::...|:::|.::   ::|.|.  ||..:||......||..||.:|:  ::|.....||.||
Mouse   408 PSDAVQRAKEVLEEISCYPENNDAK--ELKRILTQPHFMALLQTHDVVAHEVYSDEALRVTPPPT 470

  Fly  1479 PAIGAATGSTLSSPVAGPKRNLGMVVPPPVVPPPLAQRGAMPLPRGESPPPVPMPPLATMPMSMP 1543
                                                    .|...|:||
Mouse   471 ----------------------------------------SPYLNGDSP---------------- 479

  Fly  1544 VNLPMSACFGTLNDQN-DNIRIIQIEKST-EPLGATVR-NEGEAVVIGRIVRGGAAEKSGLLHEG 1605
                 .:..|.::.:| ..:|::|.:|:| ||:|.|:: ||....::.||:.||...:.|.||.|
Mouse   480 -----ESANGDMDMENVTRVRLVQFQKNTDEPMGITLKMNELNHCIVARIMHGGMIHRQGTLHVG 539

  Fly  1606 DEILEVNGQELRGKTVNEVCALLGAMQGTLTFLIVPA----------GSPPSVGVMGGTTGSQLA 1660
            |||.|:||..:..:||.::..:|..|:|::||.|||:          .||        :|..|..
Mouse   540 DEIREINGISVANQTVEQLQKMLREMRGSITFKIVPSYRTQSSSCERDSP--------STSRQSP 596

  Fly  1661 GLGGAHRDTAV-------------LHVRAHFDYDPEDDLYIPCRELGISFQKGDVLHVISREDPN 1712
            ..|.:..:.:|             ::|||.|:|||..|..|||:|.||.|:.||::.:||::|.|
Mouse   597 ANGHSSTNNSVSDLPSTTQPKGRQIYVRAQFEYDPAKDDLIPCKEAGIRFRVGDIIQIISKDDHN 661

  Fly  1713 WWQAYREGEEDQTLAGLIPSQSFQHQRETMKLAIAEEAGLARSRGKDGSGSKGATLLCARKGRKK 1777
            |||...|..::.| ||||||...|..|         .|.:|..:.|....:.     |...|:||
Mouse   662 WWQGKLENSKNGT-AGLIPSPELQEWR---------VACIAMEKTKQEQQAS-----CTWFGKKK 711

  Fly  1778 KKKASSEAGYPLYATTAPDETDPEEILTYEEVALYYPRATHKRPIVLIGPPNIGRHELRQRLMA- 1841
            |:....      |........|..:::||||| :..| |..::.:||:|...:||..::..|:.
Mouse   712 KQYKDK------YLAKHNAVFDQLDLVTYEEV-VKLP-AFKRKTLVLLGAHGVGRRHIKNTLITK 768

  Fly  1842 DSERFSAAVPHTSRARREGEVPGVDYHFITRQAFEADILARRFVEHGEYEKAYYGTSLEAIRTVV 1906
            ..:||:..:|||:|..::.|..|.:|:|::......||....::|:|.:|.|.|||.||.||.:.
Mouse   769 HPDRFAYPIPHTTRPPKKDEENGKNYYFVSHDQMMQDISNNEYLEYGSHEDAMYGTKLETIRKIH 833

  Fly  1907 ASGKICVLNLHPQ----------------------------------------SLKLLRASDLKP 1931
            ..|.|.:|::.||                                        :||:||.::..|
Mouse   834 EQGLIAILDVEPQGLEKSSGQGWLEAKSQSWSWSSTSSPWVPHWSSPERRFLLALKVLRTAEFAP 898

  Fly  1932 YVVLVAPPSLDK-LRQKKLRNGEPFKEEELKDIIATARDMEARWGHLFDMIIINNDTERAYHQLL 1995
            :||.:|.|::.. |.:          :|.|:.:...:..::..:.|.||:.||||:.:.....|.
Mouse   899 FVVFIAAPTITPGLNE----------DESLQRLQKESDVLQRTYAHYFDLTIINNEIDETIRHLE 953

  Fly  1996 AEINSLEREPQWVPAQWVH 2014
            ..:..:...|||||..||:
Mouse   954 EAVELVCTAPQWVPVSWVY 972

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
sdt	NP_001033835.2	PDZ_signaling	<54..102	CDD:238492
		L27	1423..1466	CDD:295425	13/47 (28%)
		PDZ_signaling	1562..1640	CDD:238492	31/79 (39%)
		SH3_MPP5	1673..1734	CDD:212969	32/60 (53%)
		Guanylate_kin	1820..1994	CDD:279019	53/215 (25%)
		GuKc	1831..2002	CDD:214504	51/212 (24%)
Cask	XP_011245733.1	STKc_CASK	8..313	CDD:270996	16/86 (19%)
		L27	354..407	CDD:197794	13/64 (20%)
		L27	412..462	CDD:397114	14/51 (27%)
		PDZ_signaling	494..574	CDD:238492	31/79 (39%)
		SH3_CASK	622..683	CDD:213014	32/61 (52%)
		Guanylate_kin	744..957	CDD:395500	54/222 (24%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910