DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment sdt and Mpp3

DIOPT Version :9

Sequence 1:	NP_001033835.2	Gene:	sdt / 44861	FlyBaseID:	FBgn0261873	Length:	2020	Species:	Drosophila melanogaster
Sequence 2:	NP_446120.1	Gene:	Mpp3 / 114202	RGDID:	620015	Length:	585	Species:	Rattus norvegicus

Alignment Length:	711	Identity:	213/711 - (29%)
Similarity:	341/711 - (47%)	Gaps:	175/711 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly  1350 PQAEQIDGYGELIAALTRLQNQLSKSGLSTLAGRVSAAHSVLASASVAHVLAARTAVLQRRRSRV 1414
            |...:..|..|.:|.||   :||...  |.....:.....|.:..|:.:::.....:....|...
  Rat     2 PVLSEDSGLHETLALLT---SQLRPD--SNHREEMGFLRDVFSEKSLGYLMKIHEKLRYYERQSP 61

  Fly  1415 SGPLHHSSLGLQKDIVELLTQSNTAAAI-----ELGNLLTSHEMEGLLLAHDRIANHTDGTPSPT 1474
            : |:.||::.|.:|::|.|    .||::     ||..||::..:..:|:.||.:|
  Rat    62 T-PVLHSAMALAEDVMEEL----QAASVHSDERELLQLLSTPHLRAVLMVHDTVA---------- 111

  Fly  1475 PTPTPAIGAATGSTLSSPVAGPKRNLGMVVPPPVVPPPLAQRGAMPLPRGESPPPVPMPPLATMP 1539
                                  ::|...|:||
  Rat   112 ----------------------QKNFDPVLPP--------------------------------- 121

  Fly  1540 MSMPVNLPMSACFGTLNDQNDNIRIIQIEKSTEPLGATVRNE--GEAVVIGRIVRGGAAEKSGLL 1602
              :|.|:..       :.:.::::|:::.|:.||||||:|.:  ..|||:.||:|||||::|||:
  Rat   122 --LPDNIDE-------DFEEESVKIVRLVKNKEPLGATIRRDEHSGAVVVARIMRGGAADRSGLV 177

  Fly  1603 HEGDEILEVNGQELRGKTVNEVCALLGAMQGTLTFLIVPAGSPPSVGVMGGTTGSQLAGLGGAHR 1667
            |.|||:.||||..:..|..:|:..:|...||::|..|:||.....                 ..:
  Rat   178 HVGDELREVNGITVLHKRPDEISQILAQSQGSITLKIIPATQEED-----------------RFK 225

  Fly  1668 DTAVLHVRAHFDYDPEDDLYIPCRELGISFQKGDVLHVISREDPNWWQAYREGEEDQTLAGLIPS 1732
            ::.|. :||.|.|||.:|..|||:|.|:.||:..||.|:|::||.||||.|.|:.: ..||||||
  Rat   226 ESKVF-MRALFHYDPREDRAIPCQEAGLPFQQRQVLEVVSQDDPTWWQAKRVGDTN-LRAGLIPS 288

  Fly  1733 QSFQHQR-------------ETMKLAIAEE------------------AGLARSRGKDGSGSKGA 1766
            :.||.:|             :.::..:.::                  |||.||
  Rat   289 KQFQERRLSYRRTTGTIPSPQNLRKPLYDQPCDKETCDCDGYFKGHYVAGLRRS----------- 342

  Fly  1767 TLLCARKGRKKKKKASSEAGYPLYATTAPDETDPEEILTYEEVALY-YPRATHKRPIVLIGPPNI 1830
                .|.|.:::...|.|...|:.|       :.:.:|||||||.| :......|.:||||....
  Rat   343 ----FRLGCRERLTGSQEVKVPVGA-------ESQVLLTYEEVARYQHQPGERSRLVVLIGSLGA 396

  Fly  1831 GRHELRQRLMA-DSERFSAAVPHTSRARREGEVPGVDYHFITRQAFEADILARRFVEHGEYEKAY 1894
            ..|||:||::| |.:.|..|||||:|.|:..|..||:|||:::|||||||...:|:||||:::..
  Rat   397 HLHELKQRVVAEDPQHFGVAVPHTTRPRKSHEREGVEYHFVSKQAFEADIQHNKFLEHGEHKENL 461

  Fly  1895 YGTSLEAIRTVVASGKICVLNLHPQSLKLLRASDLKPYVVLVAPPSLDKLRQKKLRNGEPFKE-- 1957
            ||||||||:||:|..|:|::::.|::|:.||..:.||||:.|.|...:|   :|.....|..|
  Rat   462 YGTSLEAIQTVMAKNKVCLVDVEPEALRHLRTPEFKPYVIFVKPAIQEK---RKTPPVSPDSEDP 523

  Fly  1958 -----EELKDIIATARDMEARWGHLFDMIIINNDTERAYHQLLAEINSLEREPQWVPAQWV 2013
                 |:.:::.|:|..::..:|||.|.:::..|.:....||.|.|.||.::..|||..||
  Rat   524 ATPLDEQQQEMAASAAFIDQHYGHLIDTVLVRQDLQSVCSQLRAVIESLSKDTYWVPISWV 584

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
sdt	NP_001033835.2	PDZ_signaling	<54..102	CDD:238492
		L27	1423..1466	CDD:295425	14/47 (30%)
		PDZ_signaling	1562..1640	CDD:238492	36/79 (46%)
		SH3_MPP5	1673..1734	CDD:212969	32/60 (53%)
		Guanylate_kin	1820..1994	CDD:279019	73/181 (40%)
		GuKc	1831..2002	CDD:214504	73/178 (41%)
Mpp3	NP_446120.1	L27	12..64	CDD:197794	10/57 (18%)
		L27	71..121	CDD:197794	16/85 (19%)
		PDZ_signaling	135..215	CDD:238492	36/79 (46%)
		SH3_MPP3	230..291	CDD:212972	32/62 (52%)
		GuKc	395..571	CDD:214504	72/178 (40%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	510..530		4/22 (18%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0194
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D245552at33208
OrthoFinder	1	1.000	-	-		FOG0000824
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	4.820