DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment sdt and Card10

DIOPT Version :9

Sequence 1:	NP_001033835.2	Gene:	sdt / 44861	FlyBaseID:	FBgn0261873	Length:	2020	Species:	Drosophila melanogaster
Sequence 2:	XP_036014949.1	Gene:	Card10 / 105844	MGIID:	2146012	Length:	1144	Species:	Mus musculus

Alignment Length:	923	Identity:	184/923 - (19%)
Similarity:	307/923 - (33%)	Gaps:	298/923 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly  1199 RVADE--LNGNAKPVPPPRDHLRVEKDGRLVNCSPAPQLPDRRA--------------------- 1240
            |:.:|  |...|:..||..:....|.||       |..|.:.||
Mouse   366 RLEEECALLRRARGPPPGAEEKEREPDG-------ADLLSELRAENQRLTASLQELQEGLQQEMS 423

  Fly  1241 -PGNASSGSSGATTHPLQH---------QQIAQ---IVEPTLEQLDSIK-KYQEQLRRRREEEER 1291
             ||  ::||.......|:|         |::.|   .|:..|:..:.:: ||.:::...|.:...
Mouse   424 RPG--AAGSERILLDILEHDWREAQDSRQELCQKLHAVQGELQWAEELRDKYLQEMEDLRLKHRT 486

  Fly  1292 IAQQNEFLRNSLRGSRKLKALQDTATPGKAVAQQQQQATLATQVVGVENEAYLPDEDQPQAEQID 1356
            :.:..:..::  |.:..|..|::       :.:::.||..:...:.::....|.::|| ..:|:.
Mouse   487 LLKDCDLYKH--RMATVLAQLEE-------IEKERDQAIQSRDRIQLQYSQSLIEKDQ-YRKQVR 541

  Fly  1357 GY----GELIAALTRLQNQLSKSGLSTLAGRVSAAHSVLASASVAHVLAAR---TAVLQRRRSRV 1414
            |.    .||:..:|.|:.  :|:.|.....|......:.|.|| :|.|.:.   |..|....|.:
Mouse   542 GLEAERDELLTTVTSLEG--TKAMLEAQLQRTQGGSCLKACAS-SHSLCSNLSSTWSLSEFPSPL 603

  Fly  1415 SGP-LHHSSLGLQKDIVELLTQSNTAAAIELGNLLTSHEMEGLLLAHDR----------IANHTD 1468
            .|| ....:.|.:....|..|.|.  ..|...::|......|.:|...|          .::.:|
Mouse   604 GGPEATGEAGGSEPHTSEEATDSE--KEINRLSILPFPPSAGSILRRQREEDPEPPKRSFSSMSD 666

  Fly  1469 GTPSPTPTP-TPAIGAATGSTLSSPVAGPK----RNLGMVVPPPVVPPPLAQRGAMPLPRGESPP 1528
            .|.|.|..| :|.:.:::.|....|:..|:    |..|:         ....|.......|.| |
Mouse   667 ITGSVTLKPWSPGLSSSSSSDSVWPLGKPEGLLARGCGL---------DFLNRSLAIRVSGWS-P 721

  Fly  1529 PVPMPPLATMPMSMPVNLPMSACFGTLNDQNDNIRIIQIEKSTEPLGATVRNEGEAVVIGRIVRG 1593
            |..:.|....|.|||          .|.|:..              ||.||         |::.|
Mouse   722 PAGLDPQDKSPDSMP----------GLGDRWS--------------GAVVR---------RVLSG 753

  Fly  1594 GA----------AEKSGLLHEGDEILEVNGQELRGKTVNEVCALLGAMQGTLTFLI--------- 1639
            ..          ||.:||...|   ||...|: |....|:        ..||.||:
Mouse   754 PGSARTEQKEPRAEGTGLEGAG---LEAEAQQ-RTLPWNQ--------SSTLPFLLDSKACHSFH 806

  Fly  1640 --------VPAGSPPSVGVMGGTTGSQLAGLGGAHRDTAVLHVRAHFDYDPEDDLYIPCRELGIS 1696
                    .|...|                          .::||:|......|.:..|
Mouse   807 EALDAWAKGPGAEP--------------------------FYIRANFSLPERSDPHALC------ 839

  Fly  1697 FQKGDVLHVISREDPNWWQAYREGEE-----DQTLA------GLIPSQSFQHQRETMKLAIAEEA 1750
            .:..::|.::   ||    |::..:|     ..||.      |.:|:    :||....|.:.|:.
Mouse   840 VKAQEILRLV---DP----AHKRRQEWFCTRVDTLTLRDLDRGTVPN----YQRAQQLLEVQEKY 893

  Fly  1751 GLARSRGKDGSGSKGATLLCARKGRKKKKKASSEAGYPLYATTAPDETDPEEILTYEEVALYYP- 1814
            .::.......|..|...|     |..:.|.|...||..  |...|.|...|...:.:..:|..|
Mouse   894 LISSRHRSPRSNLKKRAL-----GLVRPKPAGGTAGDS--AEQLPAEPCSELERSLKPYSLVRPL 951

  Fly  1815 RATHKRPIVLIGPPNIGRHELRQRLMADSERFSAAV-PHTSRARRE---GEVPGVDYHFITRQAF 1875
            ..:..||:||: |..:....:|..|...|.|....| |..|.:..|   ...||..      :|:
Mouse   952 LVSALRPVVLL-PECLAPRLIRNLLDLPSSRLDFQVCPAESLSGEEQCTSSAPGAP------KAW 1009

  Fly  1876 EADILARRFVEHGEYEKAYYGTSLEAIRTVVASGKICVLNLHPQSLKLLRASDLKPYVVLVAPPS 1940
            .|              .|..|:.:.||:..|.. |.|:|.|..:.::.|..|::.|.|:.|
Mouse  1010 PA--------------TAGLGSRIRAIQESVGK-KHCLLELGARGVRELVHSEVYPIVIHV---- 1055

  Fly  1941 LDKLRQKKLRNGEPFKEEELKDIIATA--RDMEARWGHLFDMIIINNDTERAYHQLLAEINSLER 2003
              ::.:|.:|        |::.::...  ||.|                      ||.:....|
Mouse  1056 --EVTEKNVR--------EIRGLLGRPGWRDSE----------------------LLRQCRGSE- 1087

  Fly  2004 EPQW---VPAQWV 2013
              ||   :|..||
Mouse  1088 --QWLWGLPCSWV 1098

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
sdt	NP_001033835.2	PDZ_signaling	<54..102	CDD:238492
		L27	1423..1466	CDD:295425	9/52 (17%)
		PDZ_signaling	1562..1640	CDD:238492	20/104 (19%)
		SH3_MPP5	1673..1734	CDD:212969	14/71 (20%)
		Guanylate_kin	1820..1994	CDD:279019	37/179 (21%)
		GuKc	1831..2002	CDD:214504	34/176 (19%)
Card10	XP_036014949.1	CARD_CARD10_CARMA3	150..235	CDD:260069
		Smc	<270..>573	CDD:224117	43/227 (19%)
		SH3	822..884	CDD:418401	16/78 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0194
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900