DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment sdt and PATJ

DIOPT Version :9

Sequence 1:	NP_001033835.2	Gene:	sdt / 44861	FlyBaseID:	FBgn0261873	Length:	2020	Species:	Drosophila melanogaster
Sequence 2:	XP_011538764.1	Gene:	PATJ / 10207	HGNCID:	28881	Length:	1937	Species:	Homo sapiens

Alignment Length:	2153	Identity:	381/2153 - (17%)
Similarity:	651/2153 - (30%)	Gaps:	741/2153 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 SSRSNLSAQSSGTPSA------STISS-SQGKQ-QVVELS-------GYVIILVENVE-GKIKLY 53
            |:.|.:|.....||..      |.|.. :||:| :.:::.       |:.::.:.:.. ||:.::
Human    99 SNNSTVSGLFPWTPKLGNEDFNSVIQQMAQGRQIEYIDIERPSTGGLGFSVVALRSQNLGKVDIF 163

  Fly    54 ------GSPPDRD-NLEVGDEILEVNGLTL-ENISRTEVI------------------------- 85
                  ||..||| .|:..|:||.:|...| :|||..:.|
Human   164 VKDVQPGSVADRDQRLKENDQILAINHTPLDQNISHQQAIALLQQTTGSLRLIVAREPVHTKSST 228

  Fly    86 -RHIHDCIKSCTICL----RVRKKND-SRLAWDIGNSVQDAFVI--AVEEHARERLQRLAALNRV 142
             ..::|.....|:|.    .|...|| |.|.:.|........|:  .|.....:|..||...:.:
Human   229 SSSLNDTTLPETVCWGHVEEVELINDGSGLGFGIVGGKTSGVVVRTIVPGGLADRDGRLQTGDHI 293

  Fly   143 TPVDITQLSKKLQQTKSGTATSQRQDLSFLNESTPIYVTSFTSNQITCSSSTMTTATAGGPISAP 207
            ..:..|.:       :..|:....|.|.....|..:.|....:..|    |....|.|..|::.|
Human   294 LKIGGTNV-------QGMTSEQVAQVLRNCGNSVRMLVARDPAGDI----SVTPPAPAALPVALP 347

  Fly   208 SLATATTTVPTASSHTTTVVAQIEHG------------------ASALVSAAVAAATAADRN--- 251
            ::|:......::...|..|....:.|                  ||.:...::...:||..|
Human   348 TVASKGPGSDSSLFETYNVELVRKDGQSLGIRIVGYVGTSHTGEASGIYVKSIIPGSAAYHNGHI 412

  Fly   252 -----------------ANSTTSAALKQTANCIGNSTSSLGTTSTTSSQSTSSATGHIYQTSQAQ 299
                             ||......|:.....:..:.....|:|:||.....|..|.:.:
Human   413 QVNDKIVAVDGVNIQGFANHDVVEVLRNAGQVVHLTLVRRKTSSSTSPLEPPSDRGTVVE----- 472

  Fly   300 QQQLQQLQQQLAAAAAAGKPLQAKSLLASSLQHLAEEVDNEDLDDDDDVDGANYCGITYISYNNK 364
                               ||:..:|..:........||.||.:..:.:|......|..:....|
Human   473 -------------------PLKPPALFLTGAVETETNVDGEDEEIKERIDTLKNDNIQALEKLEK 518

  Fly   365 HAQLPTTTLPAT------TALPAAAASLATTAAIYQQRQQQQHQQQQQQQQQPVH---------- 413
            ....|...|.:.      .......|:|.|..|       ...:.|:..:..|:|
Human   519 VPDSPENELKSRWENLLGPDYEVMVATLDTQIA-------DDAELQKYSKLLPIHTLRLGVEVDS 576

  Fly   414 ---HHNHPPTASQLNRATAPAPLQLGGPVNP-SFVDAQTSTSPLMAQQLHSQH-----ADVDAAP 469
               ||......|             ||||:. ..:..:.....:...||:.:.     :.:...|
Human   577 FDGHHYISSIVS-------------GGPVDTLGLLQPEDELLEVNGMQLYGKSRREAVSFLKEVP 628

  Fly   470 PSSS--------SSSAVVVVERHVHGTTTPKTEYSTAISSGQLQQAFAELQLHSSNNNATQ---- 522
            |..:        ...|.|...|... |:.|:||....:.....:....||.|.|......:
Human   629 PPFTLVCCRRLFDDEASVDEPRRTE-TSLPETEVDHNMDVNTEEDDDGELALWSPEVKIVELVKD 692

  Fly   523 ---------QQQQHLLLSNNNNSNNSMAA---AQTTASLMKNCDLLISNNLY------------- 562
                     ..|..|..:.:.....|:.|   |:.:..|:.. |.|:|.|.|
Human   693 CKGLGFSILDYQDPLDPTRSVIVIRSLVADGVAERSGGLLPG-DRLVSVNEYCLDNTSLAEAVEI 756

  Fly   563 ----PPR-------RELLED------VIVHQASDVHSYSTSASAAAIASS--------------- 595
                ||.       :.|:||      .|:|.:|:......|.:...|.||
Human   757 LKAVPPGLVHLGICKPLVEDNEEESCYILHSSSNEDKTEFSGTIHDINSSLILEAPKGFRDEPYF 821

  Fly   596 --------------SNRSQQQQQQQQQHQLLSAAYELQQQQQLQLQQQQQQQNSPTSSISIGRTE 646
                          |..|||::.:|.:.     |:|:.:....:||:..:::            |
Human   822 KEELVDEPFLDLGKSFHSQQKEIEQSKE-----AWEMHEFLTPRLQEMDEER------------E 869

  Fly   647 LLLGDQ-SLRQDPRGNRRRSGSSIVVLDGDDLKPCLPDDYISGQHHLNHQQQLQLQQQLQQQHP- 709
            :|:.:: .|.|||..:.             :|.|            |:|         :|:..|
Human   870 ILVDEEYELYQDPSPSM-------------ELYP------------LSH---------IQEATPV 900

  Fly   710 --LQQQHYRT---HSGDIREIDQEMLTMLSV-NQDNGPHREMAVDCPDTFIARN---KTPPRYPP 765
              :.:.|:.|   |..:..| .||..|..:| :|:..|:..    ||:..:..|   ::.|..|.
Human   901 PSVNELHFGTQWLHDNEPSE-SQEARTGRTVYSQEAQPYGY----CPENVMKENFVMESLPSVPS 960

  Fly   766 PRPPQKHKK-----STNTTTTTTIT--ALTNNDHANKMLI---VAYHSSHQHEQLQQQHP----- 815
            .....:..:     :.|:...|::.  .:.|:.....:||   |......|.:....||.
Human   961 TEGNSQQGRFDDLENLNSLAKTSLDLGMIPNDVQGPSLLIDLPVVAQRREQEDLPLYQHQATRVI 1025

  Fly   816 SKTSTTTTTIALDVATQNLYNQKQQNKLEQIENYENCLQSERNEQHEQQFEQQKQHQATTAMAAT 880
            ||.|..|..::...||                  :.|   |..|:.|.:.|:.............
Human  1026 SKASAYTGMLSSRYAT------------------DTC---ELPEREEGEGEETPNFSHWGPPRIV 1069

  Fly   881 QVAQQQTPSHKLQATLSSDPNGNSNSNNNSHIVGI-------SSSSSSNNSSITDDFLCVVDGLY 938
            ::.::  |:..|..::...........|...:.||       .|.:...|:..|.|.:..|.|:
Human  1070 EIFRE--PNVSLGISIVGGQTVIKRLKNGEELKGIFIKQVLEDSPAGKTNALKTGDKILEVSGV- 1131

  Fly   939 QGRKDTASPSSSAFDEVMSKHTLDSFGSIAYRHLHQQHQATSNGNSSSNTSNTNSNTNSNTNSNS 1003
                |..:.|.|...|.:.
Human  1132 ----DLQNASHSEAVEAIK---------------------------------------------- 1146

  Fly  1004 NTNGNTSNNTAVSTKTATVTKTGVSSSNSNSNSLNSSNSSMHTSSSSSGHSSNIASATSSSSATS 1068
                |..|......::.:.|...:.:.::.:|.:                :.|....|.......
Human  1147 ----NAGNPVVFIVQSLSSTPRVIPNVHNKANKI----------------TGNQNQDTQEKKEKR 1191

  Fly  1069 SSTVPDDLSLAPPGYEV----SQQQQQQHLVATPVTMLLPPMAKHRELPVDVPDS--FIEMVKTT 1127
            ..|.|..:.|.|| |:.    |.:.:::.....         .|.|:...|:|..  .||:.|
Human  1192 QGTAPPPMKLPPP-YKALTDDSDENEEEDAFTD---------QKIRQRYADLPGELHIIELEK-- 1244

  Fly  1128 PRYPPPAHLSSRGSLLS-NGSASTAHTTLSSMGVAPSPVTATAAAAASASAACATTAVAAAAVSG 1191
                     ...|..|| .|:...:..::..:|:.|                           .|
Human  1245 ---------DKNGLGLSLAGNKDRSRMSIFVVGINP---------------------------EG 1273

  Fly  1192 VADGDAR-RVADEL------------NGNAKPV---PPPRDHLRVEKDGRLVNCSPAPQLPDRRA 1240
            .|..|.| |:.|||            :.||..:   .|.:..|...::...||.......|...:
Human  1274 PAAADGRMRIGDELLEINNQILYGRSHQNASAIIKTAPSKVKLVFIRNEDAVNQMAVTPFPVPSS 1338

  Fly  1241 PGNASSGSSGATTHPLQHQQIAQIVEPTLEQLDSIKKYQEQLRRRREEEERIAQQNEFLRNSLRG 1305
            ..::....||  |.|:..::... ||..::||...:.::.:...:...:..:|.|.
Human  1339 SPSSIEDQSG--TEPISSEEDGS-VEVGIKQLPESESFKLEDMSQVIGQGMVADQQ--------- 1391

  Fly  1306 SRKLKALQDTATPGKAVAQQQQQATLATQVVGVENEAYLPDEDQPQAEQID--GYGELIAALT-- 1366
                |||:  ..|..||:|.:|| ...|:|.....|..|.......:...|  |||...|.|:
Human  1392 ----KALE--YPPDNAVSQMKQQ-KYPTKVSFSSQEIPLAPASSYHSTDADFTGYGGFQAPLSVD 1449

  Fly  1367 ----------RLQNQLSKS----GLSTLAGRVSAAHSVLAS--ASVAHVLAARTAVLQRRRSRVS 1415
                      .:..::||.    |||.:.|:.:.....|.|  |...|::.|..
Human  1450 PATCPIVPGQEMIIEISKGRSGLGLSIVGGKDTPLFWRLGSPRAWSQHLVRAFM----------- 1503

  Fly  1416 GPLHHSSLGLQKDIVELLTQSNTAAAIELGNLLTSHEM--------EGLLLAHDRI--------- 1463
              |||                 ....:|..|.:..||:        :|.|.|.|:|
Human  1504 --LHH-----------------PVTEVEGQNAIVIHEVYEEGAAARDGRLWAGDQILEVNGVDLR 1549

  Fly  1464 -ANHTDGTPSPTPTPTPAIGAATGSTLSSPVAGPKRNLGMVVPPPVVPPPLAQRGAMPLPRGESP 1527
             ::|.:...:...||                                     |:..:.:.|.|:
Human  1550 NSSHEEAITALRQTP-------------------------------------QKVRLVVYRDEA- 1576

  Fly  1528 PPVPMPPLATMPMSMPVNLPMSACFGTLNDQNDNIRIIQIE---KSTEPLGATV--RNEGEAVVI 1587
                                      ...|: :|:.|..::   |:...||.::  :..|..|.|
Human  1577 --------------------------HYRDE-ENLEIFPVDLQKKAGRGLGLSIVGKRNGSGVFI 1614

  Fly  1588 GRIVRGGAAEKSGLLHEGDEILEVNGQELRGKTVNEVCALLGAMQGTLTFLI--VPAGSPPSVGV 1650
            ..||:||||:..|.|.:||:||.|||:::|..:...|..:|...||.:...|  :.|||..|...
Human  1615 SDIVKGGAADLDGRLIQGDQILSVNGEDMRNASQETVATILKCAQGLVQLEIGRLRAGSWTSART 1679

  Fly  1651 MG-GTTGSQ-----------------LAGLGGAHRDTAVLHVRAHFDYDPEDDLYIPCRELGISF 1697
            .. .:.|||                 |..|.|..|.:......:..|.:|        |.:.|:.
Human  1680 TSQNSQGSQQSAHSSCHPSFAPVITGLQNLVGTKRVSDPSQKNSGTDMEP--------RTVEINR 1736

  Fly  1698 QKGDVLHVI---SREDPNWWQAYREGEEDQTLAGLIP-----SQSFQHQRETMKLAIAEEAGLAR 1754
            :..|.|.:.   .|..|               .|.||     .|:......|.||.:.:......
Human  1737 ELSDALGISIAGGRGSP---------------LGDIPVFIAMIQASGVAARTQKLKVGDRIVSIN 1786

  Fly  1755 SRGKDG-SGSKGATLLCARKGR-------------KKKKKASSEAGYPLYATTA---PD--ETDP 1800
            .:..|| |.:....||....||             ...:..:...||.|.:.||   |:  ||.|
Human  1787 GQPLDGLSHADVVNLLKNAYGRIILQVVADTNISAIAAQLENMSTGYHLGSPTAEHHPEDTETPP 1851

  Fly  1801 EEILTYEE 1808
            .:|:|.|:
Human  1852 PKIITLEK 1859

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
sdt	NP_001033835.2	PDZ_signaling	<54..102	CDD:238492	18/79 (23%)
		L27	1423..1466	CDD:295425	9/60 (15%)
		PDZ_signaling	1562..1640	CDD:238492	28/84 (33%)
		SH3_MPP5	1673..1734	CDD:212969	11/68 (16%)
		Guanylate_kin	1820..1994	CDD:279019
		GuKc	1831..2002	CDD:214504
PATJ	XP_011538764.1	L27_2	8..65	CDD:117611
		PDZ_signaling	135..218	CDD:238492	18/82 (22%)
		PDZ_signaling	246..325	CDD:238492	16/85 (19%)
		PDZ_signaling	366..450	CDD:238492	10/83 (12%)
		PDZ_signaling	570..634	CDD:238492	11/76 (14%)
		PDZ	683..772	CDD:214570	13/89 (15%)
		PDZ_signaling	1066..1157	CDD:238492	17/147 (12%)
		PDZ	1236..1321	CDD:214570	21/122 (17%)
		PDZ	1459..1574	CDD:214570	27/181 (15%)
		PDZ_signaling	1586..1666	CDD:238492	27/79 (34%)
		PDZ_signaling	1729..1814	CDD:238492	21/107 (20%)
		PDZ_signaling	1852..1936	CDD:238492	3/8 (38%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0194
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810