DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment sdt and mpp4

DIOPT Version :9

Sequence 1:	NP_001033835.2	Gene:	sdt / 44861	FlyBaseID:	FBgn0261873	Length:	2020	Species:	Drosophila melanogaster
Sequence 2:	XP_031749716.1	Gene:	mpp4 / 100495166	XenbaseID:	XB-GENE-988529	Length:	684	Species:	Xenopus tropicalis

Alignment Length:	804	Identity:	198/804 - (24%)
Similarity:	336/804 - (41%)	Gaps:	235/804 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly  1318 PGKAVAQQQQQATLATQVVGVENEAYLPDEDQPQAEQIDGYGELIAALTRLQNQLSKSGLSTLAG 1382
            |.||....:...|:               |..|...|.:|..::   ||.:..:|.......:.|
Frog     4 PQKATESLRMHETM---------------EMTPSGLQENGLSQV---LTMVLEELGLYYHQDVNG 50

  Fly  1383 RVSAAHSVLASASVAHVLAARTAVLQRRRSRVSGPLHHSSLGLQKDIVELLTQSNTAAAI-ELGN 1446
             :...:::|.:..:..:|...:.:.|..:.|.. |:...:..|..::|.:|.::.::|.: ||..
Frog    51 -IGVLYNLLQAPWLQSLLKVHSCLQQYIQQRPQ-PVLPKACILSNEVVGVLRETTSSADLRELKR 113

  Fly  1447 LLTSHEMEGLLLAHDRIANHTDGTPSPTPTPTPAIGAATGSTLSSPVAGPKRNLGMVVPPPVVPP 1511
            ||.....:.||.|||.:|....                                     .||:||
Frog   114 LLQGPHFKALLSAHDMVAQADF-------------------------------------EPVLPP 141

  Fly  1512 PLAQRGAMPLPRGESPPPVPMPPLATMPMSMPVNLPMSACFGTLNDQNDNIRIIQIEKSTEPLGA 1576
                                          :|.|:|         |..:.:||:.:.|:.:||||
Frog   142 ------------------------------LPDNIP---------DNEEAMRIVCLVKNKQPLGA 167

  Fly  1577 TVRNE---GEAVVIGRIVRGGAAEKSGLLHEGDEILEVNGQELRGKTVNEVCALLGAMQGTLTFL 1638
            |::..   |: :::.|::.||.|::||||:.||:::||||..:.|....:|..:|...:||:.|.
Frog   168 TIKRHEITGD-IIVARVIHGGLADRSGLLYAGDKLVEVNGVLVDGLEPEQVIQILARSEGTIVFK 231

  Fly  1639 IVPAGSPPSVGVMGGTTGSQLAGLGGAHRDTAVLHVRAHFDYDPEDDLYIPCRELGISFQKGDVL 1703
            :    ||.:...:...|               :|:|||..||.|:.|..|||.:.|:.||:|::|
Frog   232 L----SPVNDRYISSHT---------------MLYVRAMADYWPQQDPAIPCADAGLPFQRGEIL 277

  Fly  1704 HVISREDPNWWQAYREGEEDQTLAGLIP--------------SQSF------------------- 1735
            .::.:.|..|||| |:..:....|||||              ||.|
Frog   278 QIVDQNDSLWWQA-RKASDLGRCAGLIPSNHLLKRKQREFWWSQPFMSHSCIKASQLSTIGEEED 341

  Fly  1736 ---------------------------------------------------------QHQRETMK 1743
                                                                     |.||...:
Frog   342 MKIEEKFVEADEETFESEELKGGNVICKFFCSVHRNSNHLVQDIYISMPQDLATIWMQPQRHNYR 406

  Fly  1744 LAIAEEAGLARSRGKDG---SGSKGATLLCARKGRKKKKKASSEAGYPLYATTAPDETDPEEILT 1805
            |....:......|.|||   :|.:.:..||.||.........|......|.|.|         ..
Frog   407 LEYFGQEKEDEFRDKDGNIIAGFRRSMRLCRRKTLINHMSCYSRCPSNCYHTVA---------AP 462

  Fly  1806 YEEVALYYPRATHK-RPIVLIGPPNIGRHELRQRLM-ADSERFSAAVPHTSRARREGEVPGVDYH 1868
            ||||..|..|...: |.|||:||..:|.:|:|::|: .:...|.:.||||:|.::..|..|.:|.
Frog   463 YEEVVRYQRRPCDRHRLIVLLGPSGVGVNEMRKQLIDLNPSMFKSPVPHTTRQKKTYEENGREYF 527

  Fly  1869 FITRQAFEADILARRFVEHGEYEKAYYGTSLEAIRTVVASGKICVLNLHPQSLKLLRASDLKPYV 1933
            |::::|||:.:.:..|:|:|||....||||:||::.|:.:|.||:::|.||.:..:|..:||||:
Frog   528 FVSKEAFESMVYSHGFLEYGEYNGHMYGTSVEAVKAVLDAGMICIIDLEPQCITGVRTHELKPYI 592

  Fly  1934 VLVAPPSLDKLRQKKLRNGE---------PFKEEELKDIIATARDMEARWGHLFDMIIINNDTER 1989
            :.:.|||.:.:|..: :|..         .||||:.::|..:|:.||.::|..||.:::|::.|.
Frog   593 IFIKPPSRNCMRYTR-KNASIFTDYYVNMKFKEEDFQEIEESAKKMEVQFGQFFDQVVVNDNLES 656

  Fly  1990 AYHQLLAEINSLEREPQWVPAQWV 2013
            |..||::.:...:.||||:||.|:
Frog   657 ATVQLMSILRCAQDEPQWIPASWI 680

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
sdt	NP_001033835.2	PDZ_signaling	<54..102	CDD:238492
		L27	1423..1466	CDD:295425	14/43 (33%)
		PDZ_signaling	1562..1640	CDD:238492	29/80 (36%)
		SH3_MPP5	1673..1734	CDD:212969	27/74 (36%)
		Guanylate_kin	1820..1994	CDD:279019	65/183 (36%)
		GuKc	1831..2002	CDD:214504	61/180 (34%)
mpp4	XP_031749716.1	L27	36..84	CDD:413432	6/49 (12%)
		L27	91..139	CDD:397114	15/84 (18%)
		PDZ	153..232	CDD:214570	29/79 (37%)
		SH3_MPP4	247..307	CDD:212967	26/60 (43%)
		Guanylate_kin	478..666	CDD:395500	67/188 (36%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D245552at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.010