DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment sdt and card14

DIOPT Version :9

Sequence 1:	NP_001033835.2	Gene:	sdt / 44861	FlyBaseID:	FBgn0261873	Length:	2020	Species:	Drosophila melanogaster
Sequence 2:	XP_002937355.2	Gene:	card14 / 100486738	XenbaseID:	XB-GENE-989887	Length:	972	Species:	Xenopus tropicalis

Alignment Length:	853	Identity:	159/853 - (18%)
Similarity:	276/853 - (32%)	Gaps:	263/853 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly  1248 SSGATTHPLQHQQIAQIVE--------PTLEQLDSIKKYQ-------------EQLRRRRE---- 1287
            |...|||....:::..:.|        ||.|:|.::::.|             .|||..:|
Frog   243 SKSWTTHAQCEEELLCLREENRQLRDRPTQEELGTLEEQQPLDVTLQGNQELLAQLRLSKEKLAA 307

  Fly  1288 ----------EEERIAQQNEFLR---NSLRGSRKLKALQDTATPGKAVAQQQQQATLATQVVGVE 1339
                      |::.:.|:...|:   :.||  :|.:|........|   :::.||..|..:|..|
Frog   308 SEAVEKLWEKEKDTMVQERHNLQLECDILR--KKSEAFHSHVCELK---KERDQAYRARDMVQTE 367

  Fly  1340 NEAYLPDED---QPQAEQIDGYGELIAALTRLQNQLSKSGLSTLAGRVSAAHSVLASASVAHVLA 1401
            ....|.::|   |...|..|...||:..:..||.||...  ..:.|.:.|......|....|:..
Frog   368 ISTILAEKDSLRQQVMELTDRNSELLQQILSLQEQLQTQ--REMRGSLHACEQRDVSTKSKHMRL 430

  Fly  1402 ART-AVLQRRRSRVSGPLHHSSLGLQKDIVELLTQSNTAAAIELGNLLTSHEMEGLLLAHDRIAN 1465
            .|. ||.         |....|..|...|.|..|:::...:.:||....|:..     .||...
Frog   431 VRMYAVC---------PSEEGSRSLSSSISETWTENSCQTSSDLGESFNSYAP-----PHDDYL- 480

  Fly  1466 HTDGTPSPTPTPTPAIGAATGSTLSSPVAGPKRNLGMVVPPPVVPPPLAQRGAMPLPRGESPPPV 1530
             ||.|.|.:......:......|.|....|
Frog   481 -TDLTKSASQDLPDLLQTEKTETDSEYEEG----------------------------------- 509

  Fly  1531 PMPPLATMPMS--------MPVNLP--MSACFGTLNDQNDNIRIIQIEKSTEPLGATVRNEG--- 1582
             :|..:.|..|        :.:::|  ..||       .|..|:..|....:.|...:...|
Frog   510 -LPMFSQMQSSESCSSYNNLAISVPRRRHAC-------RDTSRVTVIAFQGDDLLKQISIIGGNR 566

  Fly  1583 EAVVIGRIVRGGAAEKSGLLHEGDEILEVNGQ--------ELRGKTVNEVCALLGAMQGTLTFLI 1639
            ..:.|.|:..|.||::.. |..|.:|:.|:..        .|.|.|..:...:|..:.|.....:
Frog   567 TGIFIHRVTEGSAADEMS-LRPGYQIIAVDFDVLNPSYKVALEGMTSEDAHCILNRVNGFCCLSV 630

  Fly  1640 -------------VPAGSPPSVGVMGGTTGSQLAG-LGGAHRDTAVLHVRAHFDYDPEDDLYIPC 1690
                         :.:||..|...........:|| :||.                    |.:.|
Frog   631 KCNKDEYRKLLRDIESGSVSSGDSFYVQVNQSMAGRVGGG--------------------LQVTC 675

  Fly  1691 RELGISFQKGDVLHVISR--EDPNWWQAYR-------EGEEDQTLAGLIPSQSFQHQRETMKLAI 1746
                     |::||:...  :....|.|:|       :||     :|:||:.. |.|::.:
Frog   676 ---------GEILHITDTMYKGSYQWFAHRVNAYTMKDGE-----SGIIPNYP-QAQQQLI---- 721

  Fly  1747 AEEAGLARSRGKDGSGSKGATLLCARKGRKKKKKASSEAGYPLYATTAPD------ETDPE-EIL 1804
               ..:.....::|:         .|:.:|:.:..|::........|:.|      |..|. .:|
Frog   722 ---TTIQHLTWQNGT---------PRRPQKQIRIVSTDRCNSHLLWTSLDCGICQCEDPPAGSVL 774

  Fly  1805 -TYEEVALYYPRATH-----KRPIVLIGPPNIGRHELRQRLMADSERFSAAVPHTSRARREGEVP 1863
             |.....|.|...||     .||::|: |..:|| .|.::|.:..:....
Frog   775 GTSCFTLLPYTLVTHLKTVIPRPVLLV-PSLLGR-ILSEKLCSSKDFIKC--------------- 822

  Fly  1864 GVDYHFITRQAFEADILARRFVEHGEYEKAYYGTSLEAIRTVVASGKICVLNLHPQSLKLLRASD 1928
              |..::|...:.|..|....:...|.|......:.:.:.:|......|:|.|....|..|....
Frog   823 --DTEYLTDAEYSARYLRGDIIGEKEREDVRCCFTRQNVESVAKQNAHCILELGLSCLSALLRVG 885

  Fly  1929 LKPYVVLVAPPSLDKLRQKKLRNGEPFKEEELKDIIATARDMEARWGHLFDMIIINNDTERAYHQ 1993
            :.| ::|..|  |.:...|||:  :|.:                .|.:..|:::..:..|.
Frog   886 IYP-IILHIP--LTEKSTKKLK--KPLQ----------------WWRNCEDLLMECSQREE---- 925

  Fly  1994 LLAEINSL 2001
              ||::||
Frog   926 --AELDSL 931

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
sdt	NP_001033835.2	PDZ_signaling	<54..102	CDD:238492
		L27	1423..1466	CDD:295425	9/42 (21%)
		PDZ_signaling	1562..1640	CDD:238492	18/101 (18%)
		SH3_MPP5	1673..1734	CDD:212969	13/69 (19%)
		Guanylate_kin	1820..1994	CDD:279019	31/173 (18%)
		GuKc	1831..2002	CDD:214504	31/171 (18%)
card14	XP_002937355.2	DD	26..104	CDD:387368
		Smc	<146..>413	CDD:224117	39/176 (22%)
		PDZ_signaling	559..631	CDD:238492	15/72 (21%)
		SH3	653..717	CDD:388381	18/98 (18%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910