DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment sdt and mpp7

DIOPT Version :9

Sequence 1:	NP_001033835.2	Gene:	sdt / 44861	FlyBaseID:	FBgn0261873	Length:	2020	Species:	Drosophila melanogaster
Sequence 2:	XP_031759046.1	Gene:	mpp7 / 100127657	XenbaseID:	XB-GENE-950404	Length:	601	Species:	Xenopus tropicalis

Alignment Length:	717	Identity:	221/717 - (30%)
Similarity:	351/717 - (48%)	Gaps:	177/717 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly  1342 AYLPDEDQPQAEQIDGYGELIAALTRLQNQLSKSGLSTLAGRVSAAHSVLASASVAHVLAARTAV 1406
            |.||.:.||..:..:.       ||.|.:...:..|          ||::......|.......:
Frog    19 ATLPAQLQPHVDSQED-------LTFLWDMFGEKSL----------HSLVKIHEKLHYYEKENPM 66

  Fly  1407 LQRRRSRVSGPLHHSSLGLQKDIVELLTQSNTAAAI-ELGNLLTSHEMEGLLLAHDRIANHTDGT 1470
                      |:.||:..|.:::.|.|...:..:.| ||..||:...::.||..||.:|..:
Frog    67 ----------PVIHSATALAEELAEELQSKSLNSEIRELLKLLSKPNLKALLSVHDTVAQKS--- 118

  Fly  1471 PSPTPTPTPAIGAATGSTLSSPVAGPKRNLGMVVPPPVVPPPLAQRGAMPLPRGESPPPVPMPPL 1535
                                              ..||:||
Frog   119 ----------------------------------YDPVLPP------------------------ 125

  Fly  1536 ATMPMSMPVNLPMSACFGTLNDQNDNIRIIQIEKSTEPLGATVRNEGE--AVVIGRIVRGGAAEK 1598
                  ||         ..::|..|:::||::.|:.||||||::.:.:  |:|:.||:|||||::
Frog   126 ------MP---------DDIDDDEDSVKIIRLVKNREPLGATIKKDEKTGAIVVARIMRGGAADR 175

  Fly  1599 SGLLHEGDEILEVNGQELRGKTVNEVCALLGAMQGTLTFLIVPA--GSPPSVGVMGGTTGSQLAG 1661
            |||:|.|||:.||||..:..|...|:..:|...||.:||.|:|:  ..||:
Frog   176 SGLIHVGDELREVNGISVEDKKPEEIIHILAQSQGAITFKIIPSIKEEPPN-------------- 226

  Fly  1662 LGGAHRDTAVLHVRAHFDYDPEDDLYIPCRELGISFQKGDVLHVISREDPNWWQAYREGEEDQTL 1726
                  :...:.|:|.|||.|.:|..|||:|.|:||:|||:|.::|::|..||||..||:.:..
Frog   227 ------NDGKMFVKALFDYYPNEDKAIPCKEAGLSFRKGDILQIMSQDDATWWQAKHEGDANPR- 284

  Fly  1727 AGLIPSQSFQHQR----------------------ETMKLAIAEEAG--LARSRGKDGSGSKGAT 1767
            ||||||:.||.:|                      ||::....||..  .|.|.|...:|.:.:.
Frog   285 AGLIPSKQFQERRFALRKPVVSNQPQKVPNRKSYEETVEYEEIEEDAEFAAHSTGTYLAGFRRSF 349

  Fly  1768 LLCARKGRKKKKKASSEAGYPLYATTAPDETDPEEILTYEEVALYYPRATHK-RPIVLIGPPNIG 1831
            .| :||.||..|.        :|.....|:.|..::.||||||||..:...| |.::|:||..:|
Frog   350 RL-SRKDRKTNKF--------MYECKKSDQYDTADVPTYEEVALYQRKPNEKYRLVILVGPVGVG 405

  Fly  1832 RHELRQR-LMADSERFSAAVPHTSRARREGEVPGVDYHFITRQAFEADILARRFVEHGEYEKAYY 1895
            .:||::: |:.:|:.:...||||:|.:|..|..||:|.||::..||.||...:|:|:|||:..||
Frog   406 VNELKRKVLIGNSQHYGVTVPHTTRGKRSQENDGVEYIFISKHLFETDIHNNKFIEYGEYKNNYY 470

  Fly  1896 GTSLEAIRTVVASGKICVLNLHPQSLKLLRASDLKPYVVLVAPPSLDKLRQKKLRN--------- 1951
            ||||:::|:|:|..|||:|::.|.|||.||.|:.||:|:.:.||::::||:.: ||
Frog   471 GTSLDSVRSVLAKNKICLLDVQPNSLKHLRTSEFKPFVIFIKPPTIERLRETR-RNAKVISGKDE 534

  Fly  1952 ---GEPFKEEELKDIIATARDMEARWGHLFDMIIINNDTERAYHQLLAEINSLEREPQWVPAQWV 2013
               .:||.:|:.:::|.:|..|||::.|.||..|:|:|...||::|.:.:..||.|..|||..|:
Frog   535 RGAAKPFSDEDFEEMIQSAEAMEAQYDHFFDTTIVNDDLSAAYNELRSTLERLEMEGFWVPVSWL 599

  Fly  2014 HN 2015
            |:
Frog   600 HS 601

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
sdt	NP_001033835.2	PDZ_signaling	<54..102	CDD:238492
		L27	1423..1466	CDD:295425	13/43 (30%)
		PDZ_signaling	1562..1640	CDD:238492	36/79 (46%)
		SH3_MPP5	1673..1734	CDD:212969	32/60 (53%)
		Guanylate_kin	1820..1994	CDD:279019	75/186 (40%)
		GuKc	1831..2002	CDD:214504	72/183 (39%)
mpp7	XP_031759046.1	L27	12..68	CDD:197794	12/75 (16%)
		L27	<87..125	CDD:197794	12/74 (16%)
		PDZ_signaling	137..217	CDD:238492	36/79 (46%)
		SH3_MPP7	232..292	CDD:212966	32/60 (53%)
		GuKc	403..585	CDD:214504	72/182 (40%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D245552at33208
OrthoFinder	1	1.000	-	-		FOG0000824
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.920