DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment sad and cyp27b1

DIOPT Version :9

Sequence 1:	NP_650123.1	Gene:	sad / 44858	FlyBaseID:	FBgn0003312	Length:	520	Species:	Drosophila melanogaster
Sequence 2:	NP_001298720.1	Gene:	cyp27b1 / 793309	ZFINID:	ZDB-GENE-111005-2	Length:	505	Species:	Danio rerio

Alignment Length:	517	Identity:	141/517 - (27%)
Similarity:	235/517 - (45%)	Gaps:	66/517 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    39 PLQRFPATELPPAVAAKYVPIPRVKGL-----PVVGTLV-DLIAAGGATHLHK-YIDARHKQYGP 96
            ||.|| |......:.|.  |.|:||.|     |.....: ||....|.:.||: .::.|.| |||
Zfish    18 PLLRF-AERWADVIRAP--PTPQVKTLEQMPGPSPARFIRDLFMKRGFSRLHQLQLEGRQK-YGP 78

  Fly    97 IFRERLGGTQDAVFVSSANLMRGVFQHEGQYPQHPLPDAWTLYNQQHACQRGLFFMEGAEWLHNR 161
            :::...|... .|.|:...|::.|.:.|||:|......:|..|........||...||.||...|
Zfish    79 MWKASFGPIL-TVHVAEPELIQQVLRQEGQHPVRSELSSWKDYRALRGEGYGLLTAEGEEWQCVR 142

  Fly   162 RILNRLLL--------NGNLNWMDVHIESCTRRMVDQWKRRTAEAAAIPLAESGEIRSYELPLLE 218
            .:|::.:|        :|.||       :....::.:.|.|:.|:::..:::           :.
Zfish   143 SLLSKHMLRPQAVEAYDGALN-------AVVSDLLQKLKLRSQESSSRIVSD-----------IS 189

  Fly   219 QQLYRWSIEVLCCIMFGTSVLTC--PKIQSSLDYFTQIVHKVFEHSSRLMTFPPRLAQILRLPIW 281
            .:.||:.:|.:..::| .|.:.|  ..:....:.|.|.::.:|..:...|..|..|.::|..| |
Zfish   190 AEFYRFGLEGISSVLF-ESRIGCLDAVVPVETERFIQSINTMFVMTLLTMAMPQWLHRLLPKP-W 252

  Fly   282 RDFEANVDEVLREGAAIIDHCIRVQED-QRRPHDEALYHR-----LQAADVPGDMIKRIFVDLVI 340
            ..|....|.:.......||.  |:||: |:....|.|..|     |..|.:|...:.....:|::
Zfish   253 DTFCRCWDVMFEFAKGHIDQ--RLQEEKQKLECGEQLEGRYLTYFLSQAGLPLTSVYSNVTELLL 315

  Fly   341 AAGDTTAFSSQWALFALSKEPRLQQRL-------AKERATNDSR------LMHGLIKESLRLYPV 392
            |..||.:.:..|:|:.||:.|.:|..|       .|:|:...:.      |:..::||.||||||
Zfish   316 AGVDTISSTLSWSLYELSRHPDVQTALRDEVLSVMKDRSVPQASDVAAMPLLKAVVKEILRLYPV 380

  Fly   393 APFIGRYLPQDAQLGGHFIEKDTMVLLSLYTAGRDPSHFEQPERVLPERWCIGETEQVHKSHGSL 457
            .|...|.:.:|.::||:.|.|:|::.|..|...|||..|..|:...|:||  |:.......:.::
Zfish   381 IPANARVINKDIEVGGYVIPKNTLITLCHYATSRDPQQFRDPDSFRPQRW--GDRSDRSHPYATV 443

  Fly   458 PFAIGQRSCIGRRVALKQLHSLLGRCAAQFEMSCLNEM-PVDSVLRMVTVPDRTLRLALRPR 518
            ||.:|:|||||||:|..:::..|.|....|.|..:.|. .|..:.|.:.||:|.:.|....|
Zfish   444 PFGVGKRSCIGRRIAELEVYLALSRILMHFTMEPVRENDTVHPMTRTLLVPERQIDLRFTER 505

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
sad	NP_650123.1	p450	63..497	CDD:299894	125/470 (27%)
cyp27b1	NP_001298720.1	p450	45..493	CDD:278495	125/473 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170592737
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG48087
OrthoDB	1	1.010	-	-		D185685at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	4	3.860