DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment sad and cyp11a2

DIOPT Version :9

Sequence 1:	NP_650123.1	Gene:	sad / 44858	FlyBaseID:	FBgn0003312	Length:	520	Species:	Drosophila melanogaster
Sequence 2:	XP_021329545.1	Gene:	cyp11a2 / 563363	ZFINID:	ZDB-GENE-130911-1	Length:	512	Species:	Danio rerio

Alignment Length:	565	Identity:	139/565 - (24%)
Similarity:	239/565 - (42%)	Gaps:	119/565 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    12 RW------------LRHLLDQLLVRILSLSLFRSRCDPPPLQRFPATELPPAVAAKYVPIPRV-- 62
            ||            |:|||..::.|               ..|.||..|..:....:..||..
Zfish     3 RWSLSARLDQSVSSLKHLLQVIVTR---------------SGRAPAIGLQDSTVRPFNEIPGQWR 52

  Fly    63 KGLPVVGTLVDLIAAGGATHLHKYIDARHKQYGPIFRERLGGTQDAVFVSSANLMRG-----VFQ 122
            ..|..|.....:   ||..::|:.:......:|||:||::|      |..|.|:::.     :|:
Zfish    53 NSLKSVFAFAKM---GGLRNIHRIMVHNFNTFGPIYREKVG------FYESVNIIKPEDAAILFK 108

  Fly   123 HEGQYPQHPLPDAWTLYNQQHACQRGLFFMEGAEWLHNRRILNRLLLNGNLNWMDVHI------- 180
            .||.||:....||||.|......:.|:...:|.:|..||.|||:.:::..:....|.:
Zfish   109 AEGHYPKRLTIDAWTAYRDYRNRKYGVLLKDGEDWKSNRIILNKEVISPKVQGNFVPLLDEVGQD 173

  Fly   181 ------ESCTRRMVDQWKRRTAEAAAIPLAESGEIRSYELPLLEQQLYRWSIEVLCCIMFGTSVL 239
                  :...|...:||   |.:                   |..:|:::::|.:..:::|
Zfish   174 FVARVNKKIERSGQNQW---TTD-------------------LSHELFKFALESVSAVLYG---- 212

  Fly   240 TCPKIQSSLDY-------FTQIVHKVFEHSSRLMTFPPRLAQILRLPIWRDFEANVDEVLREGAA 297
              .::...|||       |...:..:|:.:|.::..||.|.:.:|..|||:.....|.:..:.
Zfish   213 --ERLGLLLDYIDPDSQRFIDCITLMFKTTSPMLYLPPGLLRPIRSKIWRNHVEAWDGIFNQA-- 273

  Fly   298 IIDHCIR--VQEDQRRPHDEALYHRLQAADVPGDM-----IKRIFVDLVIAAGDTTAFSSQWALF 355
              |.||:  .::.::.|.....|..:.|:.:..|.     ||....:|:....||||.:..|.|:
Zfish   274 --DRCIQNIYRQLRKNPEGNGKYTGVLASLLMLDKLSIEDIKASVTELMAGGVDTTAITLLWTLY 336

  Fly   356 ALSKEPRLQQRLAKE--RATNDSR-----------LMHGLIKESLRLYPVAPFIGRYLPQDAQLG 407
            .|::.|.||:.:..|  .|...|:           |:.|.:||:|||:|||..:.||:.:|..:.
Zfish   337 ELARNPDLQEEIRAEISAARIASKGDMVQMLKMIPLVKGTLKETLRLHPVAVSLQRYITEDIVIQ 401

  Fly   408 GHFIEKDTMVLLSLYTAGRDPSHFEQPERVLPERWCIGETEQVHKSHGSLPFAIGQRSCIGRRVA 472
            .:.|...|:|.|.||..|||...|..||:.||.|| :.......|   ||.|..|.|.|:|||:|
Zfish   402 KYHIPAGTLVQLGLYAMGRDHQVFPNPEQYLPSRW-VNSQNHYFK---SLSFGFGPRQCLGRRIA 462

  Fly   473 LKQLHSLLGRCAAQFEMSCLNEMPVDSVLRMVTVPDRTLRLALRP 517
            ..::...|......|.:....:|.|.|:..::.:|::.:.|.::|
Zfish   463 ETEMQLFLIHMLENFRIEKQRQMEVKSMFELILLPEKPIMLTIKP 507

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
sad	NP_650123.1	p450	63..497	CDD:299894	121/478 (25%)
cyp11a2	XP_021329545.1	p450	69..505	CDD:306555	121/477 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0159
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D185685at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_110753
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	4	3.720