DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment sad and cyp27c1

DIOPT Version :9

Sequence 1:	NP_650123.1	Gene:	sad / 44858	FlyBaseID:	FBgn0003312	Length:	520	Species:	Drosophila melanogaster
Sequence 2:	NP_001106808.2	Gene:	cyp27c1 / 558396	ZFINID:	ZDB-GENE-080204-68	Length:	540	Species:	Danio rerio

Alignment Length:	473	Identity:	128/473 - (27%)
Similarity:	215/473 - (45%)	Gaps:	47/473 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly    44 PATELPPAVAAKYVPIPRVKGLPVVGTLVDLIAAGGATHLHKYIDARH-KQYGPIFRERLGGTQD 107
            ||.|:..|...|  .:..:.|...|..|::.....|.:.:|: |...| |:||.||:.|. |.|.
Zfish    57 PAEEVQKAARVK--SLKEMPGPSTVANLLEFFYRDGFSRIHE-IQMEHAKKYGKIFKSRF-GPQF 117

  Fly   108 AVFVSSANLMRGVFQHEGQYPQHPLPDAWTLYNQQHACQRGLFFMEGAEWLHNRRILNRLLLNGN 172
            .|.::..:::..|.:.|...||....::|..|........||...||.|||..|.:|.:|::...
Zfish   118 VVSIADRDMVAQVLRSESATPQRGNMESWKEYRDLRGRSTGLISAEGDEWLKMRSVLRQLIMRPR 182

  Fly   173 LNWMDVHIESCTRR--MVDQWKRRTAEAAAIPLAESGEIRSYELPLLEQQLYRWSIEVLCCIMFG 235
                ||.:.|....  :.|..||       :....|.:..|..:..:....:::::|.:..|::.
Zfish   183 ----DVAVFSSDVNDVVADLVKR-------VKTLRSQQDDSQTVLNINDLFFKYAMEGVATILYE 236

  Fly   236 TSVLTC-----PKIQSSLDYFTQIVHKVFEHSSRLM---TFPPRLAQILRLPIWRDFEANVDEVL 292
            |. |.|     ||:  |.:|.|.: |.:|......|   ..|..|..|:..| |.:|.::.|.:.
Zfish   237 TR-LGCLENEIPKM--SQEYITAL-HLMFSSFKTTMYAGAIPKWLRPIIPKP-WEEFCSSWDGLF 296

  Fly   293 REGAAIIDHCIRVQEDQRRPHDE----ALYHRLQAADVPGDMIKRIFVDLVIAAGDTTAFSSQWA 353
            :.....:|..:...:.|....:|    .|.|.|...::..:.|.....::::|..|||:|:..|:
Zfish   297 KFSQIHVDKRLSEIKKQMEKSEEIKGGLLTHMLVTREMNLEEIYANMTEMLLAGVDTTSFTLSWS 361

  Fly   354 LFALSKEPRLQQRLAKE--------RATNDS----RLMHGLIKESLRLYPVAPFIGRYLPQDAQL 406
            .:.|::.|.:||::.:|        ..|.:.    .|:.||:||:|||:||.|..||....|..:
Zfish   362 TYLLARHPTIQQQIFEEVDRVLGGRVPTGEDVPYLPLIRGLVKETLRLFPVLPGNGRVTHDDLIV 426

  Fly   407 GGHFIEKDTMVLLSLYTAGRDPSHFEQPERVLPERWCIGETEQVHKSHGSLPFAIGQRSCIGRRV 471
            ||:.|.|.|.:.|..|:...|..:|.:||...|:||...:......:.||:||..|.|||||||:
Zfish   427 GGYLIPKGTQLALCHYSTSMDEENFPRPEEFRPDRWIRKDASDRVDNFGSIPFGYGIRSCIGRRI 491

  Fly   472 ALKQLHSLLGRCAAQFEM 489
            |..::|..|.:....|.:
Zfish   492 AELEMHLALTQLLQNFHI 509

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
sad	NP_650123.1	p450	63..497	CDD:299894	123/454 (27%)
cyp27c1	NP_001106808.2	p450	74..517	CDD:306555	123/454 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170592738
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0159
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG48087
OrthoDB	1	1.010	-	-		D185685at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	5	4.760