DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment sad and Cyp4c3

DIOPT Version :9

Sequence 1:	NP_650123.1	Gene:	sad / 44858	FlyBaseID:	FBgn0003312	Length:	520	Species:	Drosophila melanogaster
Sequence 2:	NP_524598.1	Gene:	Cyp4c3 / 43663	FlyBaseID:	FBgn0015032	Length:	535	Species:	Drosophila melanogaster

Alignment Length:	581	Identity:	116/581 - (19%)
Similarity:	213/581 - (36%)	Gaps:	158/581 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly    17 LLDQLLVRILSLSLFRSRCDPPPLQRFPATELPPAVAAKYV-PIPRVKGLPVVGTLVDLIAAGGA 80
            ||..:|:.::..:..|||                  ..||: .||....:|.:|..:::    ..
  Fly    33 LLGSILIFLVVYNKRRSR------------------LVKYIEKIPGPAAMPFLGNAIEM----NV 75

  Fly    81 TH--LHKYIDARHKQYGPIFRERLG------GTQDAVFVSSANLMRGVFQHEGQYPQHPLPDAWT 137
            .|  |...:....|.:|    .|:|      ||...|.         :|:.|   ...|:.::..
  Fly    76 DHDELFNRVIGMQKLWG----TRIGINRVWQGTAPRVL---------LFEPE---TVEPILNSQK 124

  Fly   138 LYNQQHACQ-------RGLFFMEGAEWLHNRRILNRLLLNGNLNWMDVHIESCTRRMVDQWKRRT 195
            ..|:.|...       .||......:|...|:||....   :...:|        ..:|.:..::
  Fly   125 FVNKSHDYDYLHPWLGEGLLTSTDRKWHSRRKILTPAF---HFKILD--------DFIDVFNEQS 178

  Fly   196 AEAAAIPLAESGEIRSYELPLLEQQLYRWSIEVLCCIMFGTSVLTCPKIQSSLDYFTQIVHKVFE 260
            |..|.....|.|.    |...|...:...:::::|....|..:..    ||:.:  ::.|..|:.
  Fly   179 AVLARKLAVEVGS----EAFNLFPYVTLCTLDIVCETAMGRRIYA----QSNSE--SEYVKAVYG 233

  Fly   261 HSSRLMTFPPRLAQILRLPIW--RDFEANV------------------DEVLREGAAIIDHCIRV 305
            ..|        :.|..:..||  .||..::                  :.|:||..|   ....:
  Fly   234 IGS--------IVQSRQAKIWLQSDFIFSLTAEYKLHQSYINTLHGFSNMVIRERKA---ELAIL 287

  Fly   306 QEDQRRPHDEALYHRLQAADVPGDMIKRIFVDLVIAAG-----------------------DTTA 347
            ||:....::.|    ..|.|..|...:..|:||:|.|.                       |||:
  Fly   288 QENNNNNNNNA----PDAYDDVGKKKRLAFLDLLIDASKEGTVLSNEDIREEVDTFMFEGHDTTS 348

  Fly   348 FSSQWALFALSKEPRLQQRLAKE---------------RATNDSRLMHGLIKESLRLYPVAPFIG 397
            .:..|.||.|...|..|:|:.:|               :...|.|.:...||:||||:|..|.:.
  Fly   349 AAISWTLFLLGCHPEYQERVVEELDSIFGDDKETPATMKNLMDMRYLECCIKDSLRLFPSVPMMA 413

  Fly   398 RYLPQDAQLGGHFIEKDTMVLLSLYTAGRDPSHFEQPERVLPERW----CIGETEQVHKSHGSLP 458
            |.:.:|..:||..:...|..::..|...|:|..|.:||:..|:.:    |.|.....:     :|
  Fly   414 RMVGEDVNIGGKIVPAGTQAIIMTYALHRNPRVFPKPEQFNPDNFLPENCAGRHPFAY-----IP 473

  Fly   459 FAIGQRSCIGRRVALKQLHSLLGRCAAQFEMSCLNEMPVDSVL-RMVTVPDRTLRLALRPR 518
            |:.|.|:|||::.|:.:..:::.....::::..::.....::| .::..|...||:.:.||
  Fly   474 FSAGPRNCIGQKFAILEEKAVISTVLRKYKIEAVDRREDLTLLGELILRPKDGLRVKITPR 534

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
sad	NP_650123.1	p450	63..497	CDD:299894	100/510 (20%)
Cyp4c3	NP_524598.1	p450	59..531	CDD:278495	105/532 (20%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24291
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	2.010