DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment sad and cyp27a7

DIOPT Version :9

Sequence 1:	NP_650123.1	Gene:	sad / 44858	FlyBaseID:	FBgn0003312	Length:	520	Species:	Drosophila melanogaster
Sequence 2:	XP_002663445.1	Gene:	cyp27a7 / 402831	ZFINID:	ZDB-GENE-081104-519	Length:	524	Species:	Danio rerio

Alignment Length:	496	Identity:	134/496 - (27%)
Similarity:	231/496 - (46%)	Gaps:	62/496 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    59 IPRVKGLPVVGTLVDLIAAGGATHLHKYIDARHKQ-YGPIFRERLGGTQDAVFVSSANLMRGVFQ 122
            :|.:|   :...|..|:..|..:.:|: :....|| |||:::..:|..| :|.::|.:|:..:.:
Zfish    56 LPEIK---IFTMLYRLLFKGYLSRMHE-LQLYEKQLYGPLYKINVGNFQ-SVALNSVDLLEELLR 115

  Fly   123 HEGQYPQHPLPDAWTLYNQQHACQRGLFFMEGAEWLHNRRILNRLLLN--GNLNWMDVHIESCTR 185
            .:.::|.......||.|........|.|..||.:|...|.:||:.:|:  .::.:.||     ..
Zfish   116 KDEKFPSRGDMTLWTEYRDMKGIGYGPFTEEGEKWYKLRAVLNKRMLHPKDSVQYGDV-----VN 175

  Fly   186 RMVDQWKRRTAEAAAIPLAESGEIRSYELPLLEQQLYRWSIEVLCCIMFGTSVLTCPK-IQSSLD 249
            .::..:.:|.....  .::.:|::.|.    |..:|||:|:|.:..|:|.|.:....| |.:...
Zfish   176 AVITDFIKRIYYLR--EMSPTGDLVSN----LTNELYRFSLEGISSILFETRIGCLEKEIPAETQ 234

  Fly   250 YFTQIVHKVFEHSSRLMTFPPRLAQILRLPIWRDFEANVDEVLREGAAIIDHCI-----RVQEDQ 309
            :|...:.::..:|..::..|......  ||.|:.:....|.:.:....:||..:     ||..:|
Zfish   235 HFINSIAQMLTYSMPVVFMPNWTRNY--LPFWQRYIGGWDGIFKFAGKMIDMKMEALQKRVDANQ 297

  Fly   310 RRPHDEALY----HRLQAADVPGDMIKRIFVDLVIAAGDTTAFSSQWALFALSKEPRLQQRLAKE 370
            ....:...|    .::.:.||.|.:     .:|::|..|||:.:..:||:.|||:|..|..|.:|
Zfish   298 EVAGEYLTYLLSNGKMSSKDVYGSV-----SELLLAGVDTTSNTMLFALYHLSKDPETQDILYQE 357

  Fly   371 RATN---DSRL-----------MHGLIKESLRLYPVAPFIGRYLPQ-DAQLGGHFIEKDTMVLLS 420
             .||   |.|:           :..:|||:||||||.|...|.:.: :..:|||...|:|...|.
Zfish   358 -VTNVLKDDRIPTAQEVNTMSYLKAVIKETLRLYPVVPMNARLIAENEVVIGGHLFPKNTTFTLC 421

  Fly   421 LYTAGRDPSHFEQPERVLPERWC-IGETEQVHKSHGSLPFAIGQRSCIGRRVALKQLHSLLGRCA 484
            .|...||...|.:|::..||||. .|.|..  ...||:||..|.|.|:|||:|..:::..|.|..
Zfish   422 HYAISRDEKVFPEPQKFKPERWLRDGRTRP--NPFGSIPFGFGVRGCVGRRIAELEMYLALARLI 484

  Fly   485 AQFEM---SCLNEMPVDSVLRMVTVPDRTLRLAL--RPRTE 520
            ..||:   ..:.|  |.|:.|.|..|||.:.|..  |.:||
Zfish   485 KLFEIRPDPTVGE--VRSLNRTVLAPDRKVNLHFVERKKTE 523

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
sad	NP_650123.1	p450	63..497	CDD:299894	122/465 (26%)
cyp27a7	XP_002663445.1	p450	68..507	CDD:278495	124/463 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170592734
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0159
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG48087
OrthoDB	1	1.010	-	-		D185685at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	5	4.760