DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment sad and Cyp4d20

DIOPT Version :9

Sequence 1:	NP_650123.1	Gene:	sad / 44858	FlyBaseID:	FBgn0003312	Length:	520	Species:	Drosophila melanogaster
Sequence 2:	NP_647723.2	Gene:	Cyp4d20 / 38311	FlyBaseID:	FBgn0035344	Length:	510	Species:	Drosophila melanogaster

Alignment Length:	573	Identity:	126/573 - (21%)
Similarity:	228/573 - (39%)	Gaps:	135/573 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    13 WLRHLLDQLLVRILSLSLFRSRCDPPPLQRFPATELPPAVAAKYVPIPRVKGLPVVGTLVDLIAA 77
            ||. |:...|:.:|:....|.|      ||        .:|.:...||....:|::|..:..:..
  Fly     2 WLT-LITGALILLLTWDFGRKR------QR--------VLAFEKSAIPGPISIPILGCGLQALHL 51

  Fly    78 GGATHLHKYIDARHKQYGPIFR-----ERLGGTQDAVF----VSSANLMRGVFQHEGQYPQHPLP 133
             ||.::..::..:..:||..||     |.|..|:|..:    :||..|:     .:||..::..|
  Fly    52 -GAENIIGWVGEKFDKYGKTFRFWILGESLIYTKDLQYFETILSSTTLL-----EKGQLYEYLRP 110

  Fly   134 DAWTLYNQQHACQRGLFFMEGAEWLHNRRILNRL----LLNGNLNWMDVHIESCTRRMVDQWKRR 194
                ..|.      ||....|.:|...|:|....    :|...:..||.|    :..|||..::.
  Fly   111 ----FLND------GLLVSTGRKWHARRKIFTHAFHFKVLEHYVEIMDRH----SSVMVDNLRKV 161

  Fly   195 TAEAAAIPLAESGEIRSYELPLLEQQLYRWSIEVLCCIMFGTSVLTCPKIQSSLDY-----FTQI 254
            .....|:.:.:...:.              :::|:.....|..|    ..|:..|:     ...:
  Fly   162 ADGKTAVDMLKYVSLA--------------ALDVITEAAMGVQV----NAQNDPDFPYIKALKSV 208

  Fly   255 VH----KVFEHSSRLMTFPPRLAQILR------LPIWRDFEANVDEVLREGAAIIDHCIRVQEDQ 309
            |:    ::|..|.|.....|..|.:|.      :.:..||   .|:|:.|.          :|..
  Fly   209 VYIQPDRMFRFSRRYNWLFPLAAPLLHRQLLSDIRVMHDF---TDKVISER----------RETV 260

  Fly   310 RRPHDEALYHRLQAADVP-GDMIKRIFVDLVIAAG-----------------------DTTAFSS 350
            ||...:..|..|...|.. |...:...:|:::.:.                       |||:...
  Fly   261 RRAKADGTYRPLSLGDAEIGSKSQMALLDILLQSSINNQPLSDADIREEVDTFMFEGDDTTSSGV 325

  Fly   351 QWALFALSKEPRLQQRLAKE---------------RATNDSRLMHGLIKESLRLYPVAPFIGRYL 400
            ..||:|:::.|.:|||:.:|               ....|.:.:..:|||::||||..|.|||:.
  Fly   326 SHALYAIARHPEVQQRIFEELQRVLGPDASAPVTQAQLQDLKYLDCVIKETMRLYPPVPAIGRHA 390

  Fly   401 PQDAQLGGHFIEKDTMVLLSLYTAGRDPSHFEQPERVLPERWCIGETEQVHKSHGSLPFAIGQRS 465
            .::.::|...|..:|.:.|.||.|.||.::|..|....|||: :.:.||.|.:...:||:.|.::
  Fly   391 QKELEIGDKTIPANTSIYLVLYYAHRDANYFPDPLSFRPERF-LEDQEQGHNTFAYVPFSAGPKN 454

  Fly   466 CIGRRVALKQLHSLLGRCAAQFEMSCLNEMPVDSVLRMVTVPDRTLRLALRPR 518
            |||::.|:.::..|:.:....:|:..|.| .:..:|..:......:.:.||||
  Fly   455 CIGQKFAVLEMKVLISKVLRFYELLPLGE-ELKPMLNFILRSASGINVGLRPR 506

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
sad	NP_650123.1	p450	63..497	CDD:299894	109/500 (22%)
Cyp4d20	NP_647723.2	p450	34..493	CDD:278495	111/511 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24291
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	2.010