DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment sad and Cyp49a1

DIOPT Version :9

Sequence 1:	NP_650123.1	Gene:	sad / 44858	FlyBaseID:	FBgn0003312	Length:	520	Species:	Drosophila melanogaster
Sequence 2:	NP_001246256.1	Gene:	Cyp49a1 / 36105	FlyBaseID:	FBgn0033524	Length:	589	Species:	Drosophila melanogaster

Alignment Length:	532	Identity:	129/532 - (24%)
Similarity:	220/532 - (41%)	Gaps:	109/532 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    25 ILSLSLFRSRCDPPPLQRFPATELPPAVAAKYVPIPRVKGLPVVGT---LVDLIAAGGATHLHKY 86
            :.|::..|:.....|.:   .|..|.|....|..:|....||::|.   ...||.....:.|.|.
  Fly    72 VTSVATTRTTASSLPAE---TTSSPAAAVRPYSEVPGPYPLPLIGNSWRFAPLIGTYKISDLDKV 133

  Fly    87 IDARHKQYGPIFRERLGGT---QDAVFVSSANLMRGVFQHEGQYPQHP-LPDAWTLYNQQHACQR 147
            ::..|..||.:  .::||.   .|.:||...:.:|.:|:.|...|..| :|   :|.:.:...:|
  Fly   134 MNELHVNYGKM--AKVGGLIGHPDLLFVFDGDEIRNIFKKEEAMPHRPSMP---SLRHYKGDLRR 193

  Fly   148 -------GLFFMEGAEWLHNRRILNRLLLNGNLNWMDVHIESCTRRMVDQWKRRTAEAAAIPLAE 205
                   ||..:.|.:|...|:.:..:||                      :.:||:....||.:
  Fly   194 DFFGDVAGLIGVHGPKWEAFRQEVQHILL----------------------QPQTAKKYIPPLND 236

  Fly   206 -----SGEI-----RSYELPL-LEQQLYRWSIEVLCCIMFGTSVLTCPKIQSSLDYFTQIVHKVF 259
                 .|.|     ...|||. ...:||:|::|.:..:...|. |.|...:.|     :...::.
  Fly   237 IASEFMGRIELMRDEKDELPANFLHELYKWALESVGRVSLDTR-LGCLSPEGS-----EEAQQII 295

  Fly   260 EHSSRLMTFPPRLAQILRLPIWRDFEANVDEVLREGAAIIDH----CIR--VQEDQRRPHDEALY 318
            |..:......|.|.  ||:|:||.:..   :..|.....:|.    |::  .:...:...|||..
  Fly   296 EAINTFFWAVPELE--LRMPLWRIYPT---KAYRSFVKALDQFTAICMKNIGKTMDKADADEARG 355

  Fly   319 HRLQAADVPGDMIKRIF-------------VDLVIAAGDTTAFSSQWALFALSKEPRLQQRL--- 367
            .....||:  .:::||.             :||.:...|||:.::...::.|:|.|..|::|
  Fly   356 LSKSEADI--SIVERIVRKTGNRKLAAILALDLFLVGVDTTSVAASSTIYQLAKNPDKQKKLFDE 418

  Fly   368 ------AKERATNDSRL-----MHGLIKESLRLYPVAPFIGRYLPQDAQLGGHFIEKDTMVLLSL 421
                  .:|...|.:.|     :...:||:||:.||....||.|..||.:.|:.:.|.|.|:...
  Fly   419 LQKVFPHREADINQNVLEQMPYLRACVKETLRMRPVVIANGRSLQSDAVINGYHVPKGTHVIFPH 483

  Fly   422 YTAGRDPSHFEQPERVLPERWCIGETEQVHKSHG--------SLPFAIGQRSCIGRRVALKQLHS 478
            .....||::|.:|:|.|||||....|:.....|.        ||||..|:|.|:|||.|..:||:
  Fly   484 LVVSNDPAYFPEPKRFLPERWLKQSTDAAGCPHANQKIHPFVSLPFGFGRRMCVGRRFAEIELHT 548

  Fly   479 LLGRCAAQFEMS 490
            ||.:...::::|
  Fly   549 LLAKIFRKYKVS 560

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
sad	NP_650123.1	p450	63..497	CDD:299894	121/494 (24%)
Cyp49a1	NP_001246256.1	p450	104..565	CDD:299894	122/497 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0159
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D185685at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	3	2.820