Protein Alignment sad and CYP4V2

DIOPT Version :10

• Sequence 1: NP_650123.1
• Gene: sad / 44858
• FlyBaseID: FBgn0003312
• Length: 520
• Species: Drosophila melanogaster
• Sequence 2: NP_997235.3
• Gene: CYP4V2 / 285440
• HGNCID: 23198
• Length: 525
• Species: Homo sapiens
• Alignment Length: 500
• Identity: 101/500 - (20%)
• Similarity: 178/500 - (35%)
• Gaps: 169/500 - (33%)

  Fly   120 VFQHEGQYPQHPLPDAW-------TLYNQQHA----------------------CQRGLFFMEGA 155
            :.::..:|...||...|       .|||.::.                      ...||....|.
Human    77 IIEYTEEYRHMPLLKLWVGPVPMVALYNAENVEVILTSSKQIDKSSMYKFLEPWLGLGLLTSTGN 141

  Fly   156 EWLHNRRIL----NRLLLNGNLNWMDVHIESCTRRMVDQWKRRTAEAAAIPLAESGEIRSYELPL 216
            :|...|::|    :..:|...|:.|:.......:::...
Human   142 KWRSRRKMLTPTFHFTILEDFLDIMNEQANILVKKLEKH-------------------------- 180

  Fly   217 LEQQLYR-------WSIEVLCCIMFGTSVLTCPKIQSSLD-YFTQIVHKVFEHSSRLMTFPPRLA 273
            :.|:.:.       .:::::|....|.::    ..||:.| .:.:.|:::.|...|.:..|
Human   181 INQEAFNCFFYITLCALDIICETAMGKNI----GAQSNDDSEYVRAVYRMSEMIFRRIKMP---- 237

  Fly   274 QILRLPIW---------------------------RDFEANVDEVLR-----------EGAAIID 300
             .|.|.:|                           |..|.|.:|..|           :..|.:|
Human   238 -WLWLDLWYLMFKEGWEHKKSLQILHTFTNSVIAERANEMNANEDCRGDGRGSAPSKNKRRAFLD 301

  Fly   301 HCIRVQEDQRRPHDEALYHRLQAADVPGDMIKRIFVDLVIAAG-DTTAFSSQWALFALSKEPRLQ 364
            ..:.|.:|:.        :||...|:      |..||..:..| ||||.:..|:|:.|...|.:|
Human   302 LLLSVTDDEG--------NRLSHEDI------REEVDTFMFEGHDTTAAAINWSLYLLGSNPEVQ 352

  Fly   365 QRLAKE----------RATNDS----RLMHGLIKESLRLYPVAPFIGRYLPQDAQLGGHFIEKDT 415
            :::..|          .||.:.    |.:..:|||:|||:|..|...|.:.:|.::.|:.:.|.|
Human   353 KKVDHELDDVFGKSDRPATVEDLKKLRYLECVIKETLRLFPSVPLFARSVSEDCEVAGYRVLKGT 417

  Fly   416 MVLLSLYTAGRDPSHFEQPERVLPERWCIGETEQVHKSHGSLPFAIGQRSCIGRRVALKQLHSLL 480
            ..::..|...|||.:|..||...|||: ..|..|....:..:||:.|.|:|||::.|:.:..::|
Human   418 EAVIIPYALHRDPRYFPNPEEFQPERF-FPENAQGRHPYAYVPFSAGPRNCIGQKFAVMEEKTIL 481

  Fly   481 GRCAAQFEMSCLNEMPVDSVLRMVTVPDRTLR--------LALRP 517
                     ||        :||...:.....|        |.|||
Human   482 ---------SC--------ILRHFWIESNQKREELGLEGQLILRP 509

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
sad	NP_650123.1	CYP24A1-like	91..512	CDD:410677	96/485 (20%)
CYP4V2	NP_997235.3	CYP4V	76..515	CDD:410773	100/499 (20%)