DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment sad and Cyp24a1

DIOPT Version :9

Sequence 1:	NP_650123.1	Gene:	sad / 44858	FlyBaseID:	FBgn0003312	Length:	520	Species:	Drosophila melanogaster
Sequence 2:	NP_963966.1	Gene:	Cyp24a1 / 25279	RGDID:	2462	Length:	514	Species:	Rattus norvegicus

Alignment Length:	537	Identity:	148/537 - (27%)
Similarity:	235/537 - (43%)	Gaps:	63/537 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly    18 LDQLLVRILSLSLFRSRCDPPPLQRFPATELPPAVAAKYVP---------------IPRVKGLPV 67
            :|:....|..|...|....||   |...::...:.|.|.||               :|.....|:
  Rat     5 IDKRRTLIAFLRRLRDLGQPP---RSVTSKASASRAPKEVPLCPLMTDGETRNVTSLPGPTNWPL 66

  Fly    68 VGTLVDLIAAGGATHLHKYIDARHKQYGPIFRERLGGTQDAVFVSSANLMRGVFQHEGQYPQHPL 132
            :|:|:::...||....|..:...||:||.|||.:| |:.|:|.:.|.:|:..:::.|..:||...
  Rat    67 LGSLLEIFWKGGLKKQHDTLAEYHKKYGQIFRMKL-GSFDSVHLGSPSLLEALYRTESAHPQRLE 130

  Fly   133 PDAWTLYNQQHACQRGLFFMEGAEWLHNRRILNRLLLNGNLNWMDVHIESCTRR---MVDQWKRR 194
            ...|..|........||..:||.||...|....:.|:.      .|.|....::   ::..:..|
  Rat   131 IKPWKAYRDHRNEAYGLMILEGQEWQRVRSAFQKKLMK------PVEIMKLDKKINEVLADFLER 189

  Fly   195 TAEAAAIPLAESGEIRSYELPLLEQQLYRWSIEVLCCIM----FGTSVLTCPKIQSSLDYFTQIV 255
            ..|..    .|.|.|     |.|..:|.:||.|.:|.::    ||  :|.....:.:|.:.|.|
  Rat   190 MDELC----DERGRI-----PDLYSELNKWSFESICLVLYEKRFG--LLQKETEEEALTFITAI- 242

  Fly   256 HKVFEHSSRLMTFPPRLAQILRLPIWRDFEANVDEVLREGAAIIDHCIRVQEDQRRPHDEALYHR 320
            ..:.....::|..|..|.:.|...:|:......|.:.:.....||:  |:|...::|..:.|...
  Rat   243 KTMMSTFGKMMVTPVELHKRLNTKVWQAHTLAWDTIFKSVKPCIDN--RLQRYSQQPGADFLCDI 305

  Fly   321 LQAADVPGDMIKRIFVDLVIAAGDTTAFSSQWALFALSKEPRLQQRLAKE-----------RATN 374
            .|...:....:.....:|.:||.:|||.|..|.|:.||:.|:.|:||.:|           || .
  Rat   306 YQQDHLSKKELYAAVTELQLAAVETTANSLMWILYNLSRNPQAQRRLLQEVQSVLPDNQTPRA-E 369

  Fly   375 DSRLMHGL---IKESLRLYPVAPFIGRYLPQDAQLGGHFIEKDTMVLLSLYTAGRDPSHFEQPER 436
            |.|.|..|   :|||:||.|..||..|.|.:...||.:.:.|.|::.|:....|....:||...:
  Rat   370 DLRNMPYLKACLKESMRLTPSVPFTTRTLDKPTVLGEYALPKGTVLTLNTQVLGSSEDNFEDSHK 434

  Fly   437 VLPERWCIGETEQVHKSHGSLPFAIGQRSCIGRRVALKQLHSLLGRCAAQFEMSCLNEMPVDSVL 501
            ..||||.  :.|:.......|||.||:|.|||||:|..|||..|.....::::...:..||:.:.
  Rat   435 FRPERWL--QKEKKINPFAHLPFGIGKRMCIGRRLAELQLHLALCWIIQKYDIVATDNEPVEMLH 497

  Fly   502 RMVTVPDRTLRLALRPR 518
            ..:.||.|.|.:|.|||
  Rat   498 LGILVPSRELPIAFRPR 514

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
sad	NP_650123.1	p450	63..497	CDD:299894	126/454 (28%)
Cyp24a1	NP_963966.1	CYP24A1	90..508	CDD:410738	125/441 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166351011
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0159
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D185685at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	4.750