DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment sad and Cyp12d1-p

DIOPT Version :9

Sequence 1:	NP_650123.1	Gene:	sad / 44858	FlyBaseID:	FBgn0003312	Length:	520	Species:	Drosophila melanogaster
Sequence 2:	NP_001286304.1	Gene:	Cyp12d1-p / 246648	FlyBaseID:	FBgn0050489	Length:	521	Species:	Drosophila melanogaster

Alignment Length:	485	Identity:	111/485 - (22%)
Similarity:	191/485 - (39%)	Gaps:	87/485 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    56 YVPIPRVKGLPVVGTLVDLIAAGGA---THLHKYIDARHKQYGPIF-RERLGGTQDAVFVSSANL 116
            |..|||    |.....:.....||.   ..:.:|..|..|:||.|: ...:.|.:|.|...:...
  Fly    42 YDEIPR----PNKFKFMRAFMPGGEFQNASITEYTSAMRKRYGDIYVMPGMFGRKDWVTTFNTKD 102

  Fly   117 MRGVFQHEGQYP------------QHPLPDAWTLYNQQHACQRGLFFMEGAEWLHNRRILNRLLL 169
            :..||::||.:|            :|..||   :|.:    .:||...:...|...|..:|.:.:
  Fly   103 IEMVFRNEGIWPRRDGLDSIVYFREHVRPD---VYGE----VQGLVASQNEAWGKLRSAINPIFM 160

  Fly   170 N-GNLNWMDVHIESCTRRMVDQWKRRTAEAAAIPLAESGEIRSYELPL-LEQQLYRWSIEVLCCI 232
            . ..|......:.:.....:::.|            |..:.::.|:|. ...::.|...|.|..:
  Fly   161 QPRGLRMYYEPLSNINNEFIERIK------------EIRDPKTLEVPEDFTDEISRLVFESLGLV 213

  Fly   233 MFGTSVLTCPKIQSSLDYFT--QIVHKVFEHSSRLMTFPPRLAQILRLPIWRDFEANVDEVLREG 295
            .|...:....|.:.:.|..|  |....:|..:.:| ...|.:.:|:..|.:|..:..:::.|
  Fly   214 AFDRQMGLIRKNRDNSDALTLFQTSRDIFRLTFKL-DIQPSMWKIISTPTYRKMKRTLNDSL--- 274

  Fly   296 AAIIDHCIRVQEDQRRPHDEALYHRLQAADV--PGDMIKRIF-----------VDLVIAAGDTTA 347
                    .|.:...:.:.:||..|.||.:.  ...|::|:.           :|::.|..|.||
  Fly   275 --------NVAQKMLKENQDALEKRRQAGEKINSNSMLERLMEIDPKVAVIMSLDILFAGVDATA 331

  Fly   348 FSSQWALFALSKEPRLQQRLAKE----RATNDSRL----------MHGLIKESLRLYPVAPFIGR 398
            ......|..|||.|..|.:|.:|    ..|.||.|          :..:|||:||.||......|
  Fly   332 TLLSAVLLCLSKHPDKQAKLREELLSIMPTKDSLLNEENMKDMPYLRAVIKETLRYYPNGLGTMR 396

  Fly   399 YLPQDAQLGGHFIEKDTMVLLSLYTAGRDPSHFEQPERVLPERWCIGETEQVHKSHGS----LPF 459
            ....|..|.|:.:.|.|.|||......::.:::.:|:..||||| :.:.|...|...|    |||
  Fly   397 TCQNDVILSGYRVPKGTTVLLGSNVLMKEATYYPRPDEFLPERW-LRDPETGKKMQVSPFTFLPF 460

  Fly   460 AIGQRSCIGRRVALKQLHSLLGRCAAQFEM 489
            ..|.|.|||:||...::.:.:.:....|.:
  Fly   461 GFGPRMCIGKRVVDLEMETTVAKLIRNFHV 490

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
sad	NP_650123.1	p450	63..497	CDD:299894	107/478 (22%)
Cyp12d1-p	NP_001286304.1	p450	70..508	CDD:299894	104/453 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0159
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D185685at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	3	2.820