Protein Alignment sad and CYP27B1

DIOPT Version :10

• Sequence 1: NP_650123.1
• Gene: sad / 44858
• FlyBaseID: FBgn0003312
• Length: 520
• Species: Drosophila melanogaster
• Sequence 2: NP_000776.1
• Gene: CYP27B1 / 1594
• HGNCID: 2606
• Length: 508
• Species: Homo sapiens
• Alignment Length: 492
• Identity: 139/492 - (28%)
• Similarity: 210/492 - (42%)
• Gaps: 76/492 - (15%)

  Fly    71 LVDLIAAGGATHLHKYIDARHKQYGPIFRERLGGTQDAVFVSSANLMRGVFQHEGQYPQHPLPDA 135
            |.:|...||.:.||:........:||::.... ||...|:|::..|:..:.:.||..|:......
Human    49 LAELFCKGGLSRLHELQVQGAAHFGPVWLASF-GTVRTVYVAAPALVEELLRQEGPRPERCSFSP 112

  Fly   136 WTLYN--QQHACQRGLFFMEGAEWLHNRRILNRLLLN--------GNLNWMDVHIESCTRRMVDQ 190
            ||.:.  :|.||  ||...||.||...|.:|..|||.        |.||.:   :....||:..|
Human   113 WTEHRRCRQRAC--GLLTAEGEEWQRLRSLLAPLLLRPQAAARYAGTLNNV---VCDLVRRLRRQ 172

  Fly   191 WKRRTAEAAAIPLAESGEIRSYELPLLEQQLYRWSIEVLCCIMFGTSVLTC--PKIQSSLDYFTQ 253
            ..|.|...|.: ...:||            .|::.:|.:..::.| |.|.|  .::....:.|.:
Human   173 RGRGTGPPALV-RDVAGE------------FYKFGLEGIAAVLLG-SRLGCLEAQVPPDTETFIR 223

  Fly   254 IVHKVFEHSSRLMTFPPRLAQILRLPIW----RDFE------------ANVDEVLREGAAIIDHC 302
            .|..||..:...|..|..|..::..| |    ||::            ...:..:|.|.
Human   224 AVGSVFVSTLLTMAMPHWLRHLVPGP-WGRLCRDWDQMFAFAQRHVERREAEAAMRNGG------ 281

  Fly   303 IRVQEDQRRPHDEALYHRLQAADVPGDMIKRIFVDLVIAAGDTTAFSSQWALFALSKEPRLQQRL 367
               |.::.......|.|.|...::|...|.....:|::|..||.:.:..|||:.||:.|.:|..|
Human   282 ---QPEKDLESGAHLTHFLFREELPAQSILGNVTELLLAGVDTVSNTLSWALYELSRHPEVQTAL 343

  Fly   368 AKE-------------RATNDSR--LMHGLIKESLRLYPVAPFIGRYLPQDAQLGGHFIEKDTMV 417
            ..|             .||..|:  |:..::||.||||||.|...|...:|..:|.:.|.|:|:|
Human   344 HSEITAALSPGSSAYPSATVLSQLPLLKAVVKEVLRLYPVVPGNSRVPDKDIHVGDYIIPKNTLV 408

  Fly   418 LLSLYTAGRDPSHFEQPERVLPERWCIGETEQVHKSHGSLPFAIGQRSCIGRRVALKQLHSLLGR 482
            .|..|...|||:.|.:|....|.|| :||....| ...||||..|:|||:|||:|..:|...|.:
Human   409 TLCHYATSRDPAQFPEPNSFRPARW-LGEGPTPH-PFASLPFGFGKRSCMGRRLAELELQMALAQ 471

  Fly   483 CAAQFEMSC-LNEMPVDSVLRMVTVPDRTLRLALRPR 518
            ....||:.. ....||....|.|.||:|::.|....|
Human   472 ILTHFEVQPEPGAAPVRPKTRTVLVPERSINLQFLDR 508

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
sad	NP_650123.1	CYP24A1-like	91..512	CDD:410677	131/464 (28%)
CYP27B1	NP_000776.1	CYP27B1	68..503	CDD:410741	131/466 (28%)