DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment sad and CYP11B2

DIOPT Version :9

Sequence 1:	NP_650123.1	Gene:	sad / 44858	FlyBaseID:	FBgn0003312	Length:	520	Species:	Drosophila melanogaster
Sequence 2:	NP_000489.3	Gene:	CYP11B2 / 1585	HGNCID:	2592	Length:	503	Species:	Homo sapiens

Alignment Length:	521	Identity:	143/521 - (27%)
Similarity:	229/521 - (43%)	Gaps:	72/521 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    28 LSLFRSRCDPPPLQRFPATELPPAVAAKYVPIPRVKGLPVVGTLVDLIAAGGATHLHKYIDARHK 92
            |||.|:|.......|.|.|.||      :..:|:..|...: .|:.:....|..|||..:....:
Human    16 LSLQRARALGTRAARAPRTVLP------FEAMPQHPGNRWL-RLLQIWREQGYEHLHLEMHQTFQ 73

  Fly    93 QYGPIFRERLGGTQDAVFVSSANLMRGVFQHEGQYPQHPLPDAWTLYNQQHACQRGLFFMEGAEW 157
            :.|||||..|||.: .|.|.....:..:.|.:..:|...:.:.|..|.|....:.|:|.:.|.||
Human    74 ELGPIFRYNLGGPR-MVCVMLPEDVEKLQQVDSLHPCRMILEPWVAYRQHRGHKCGVFLLNGPEW 137

  Fly   158 LHNRRILNRLLLNGNLNWMDVHIESCTRR---MVDQWKRRTAEAAAIPLAESGEIRSYELPL-LE 218
            ..||..||          .||......:|   |||...|..::|....:.::..   ..|.| ::
Human   138 RFNRLRLN----------PDVLSPKAVQRFLPMVDAVARDFSQALKKKVLQNAR---GSLTLDVQ 189

  Fly   219 QQLYRWSIEVLCCIMFGTSVLTCPKIQSSLDY-FTQIVHKVFEHSSRLMTFPPRLAQILRLPIWR 282
            ..::.::||.....:||..:.......||... |...:..:|:.:.:||..|..|::.:...:|:
Human   190 PSIFHYTIEASNLALFGERLGLVGHSPSSASLNFLHALEVMFKSTVQLMFMPRSLSRWISPKVWK 254

  Fly   283 D-FEANVDEVLREGAAIIDHCIRVQEDQRRPHDEALYHR-----------LQAADVPGDMIKRIF 335
            : ||| .|.:.:.|    |:||      ::.:.|..::|           |..|::..:.||...
Human   255 EHFEA-WDCIFQYG----DNCI------QKIYQELAFNRPQHYTGIVAELLLKAELSLEAIKANS 308

  Fly   336 VDLVIAAGDTTAFSSQWALFALSKEPRLQQRLAKE-------------RATNDSRLMHGLIKESL 387
            ::|...:.|||||.....||.|::.|.:||.|.:|             :||.:..|:...:||:|
Human   309 MELTAGSVDTTAFPLLMTLFELARNPDVQQILRQESLAAAASISEHPQKATTELPLLRAALKETL 373

  Fly   388 RLYPVAPFIGRYLPQDAQLGGHFIEKDTMVLLSLYTAGRDPSHFEQPERVLPERW--CIGETEQV 450
            |||||..|:.|.:..|..|..:.|...|:|.:.||:.||:.:.|.:|||..|:||  ..|.....
Human   374 RLYPVGLFLERVVSSDLVLQNYHIPAGTLVQVFLYSLGRNAALFPRPERYNPQRWLDIRGSGRNF 438

  Fly   451 HKSHGSLPFAIGQRSCIGRRVALKQLHSLLGRCAAQFEMSCLNE----MPVDSVLRMVTVPDRTL 511
            |    .:||..|.|.|:|||:|..::..||......|.:..|.:    |....:||..|.|..|.
Human   439 H----HVPFGFGMRQCLGRRLAEAEMLLLLHHVLKHFLVETLTQEDIKMVYSFILRPGTSPLLTF 499

  Fly   512 R 512
            |
Human   500 R 500

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
sad	NP_650123.1	p450	63..497	CDD:299894	126/469 (27%)
CYP11B2	NP_000489.3	p450	42..454	CDD:365848	119/441 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0159
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D185685at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.820