DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment sad and CYP11B1

DIOPT Version :9

Sequence 1:	NP_650123.1	Gene:	sad / 44858	FlyBaseID:	FBgn0003312	Length:	520	Species:	Drosophila melanogaster
Sequence 2:	NP_000488.3	Gene:	CYP11B1 / 1584	HGNCID:	2591	Length:	503	Species:	Homo sapiens

Alignment Length:	519	Identity:	137/519 - (26%)
Similarity:	224/519 - (43%)	Gaps:	64/519 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    28 LSLFRSRCDPPPLQRFPATELPPAVAAKYVPIPRVKGLPVVGTLVDLIAAGGATHLHKYIDARHK 92
            |||.|::.......|.|.|.||      :..:||..|...: .|:.:....|...||..:....:
Human    16 LSLQRAQALGTRAARVPRTVLP------FEAMPRRPGNRWL-RLLQIWREQGYEDLHLEVHQTFQ 73

  Fly    93 QYGPIFRERLGGTQDAVFVSSANLMRGVFQHEGQYPQHPLPDAWTLYNQQHACQRGLFFMEGAEW 157
            :.|||||..|||. ..|.|.....:..:.|.:..:|.....:.|..|.|....:.|:|.:.|.||
Human    74 ELGPIFRYDLGGA-GMVCVMLPEDVEKLQQVDSLHPHRMSLEPWVAYRQHRGHKCGVFLLNGPEW 137

  Fly   158 LHNRRILNRLLLNGNLNWMDVHIESCTRR---MVDQWKRRTAEAAAIPLAESGEIRSYELPL-LE 218
            ..||..||..:|:.|          ..:|   |||...|..::|....:.::..   ..|.| ::
Human   138 RFNRLRLNPEVLSPN----------AVQRFLPMVDAVARDFSQALKKKVLQNAR---GSLTLDVQ 189

  Fly   219 QQLYRWSIEVLCCIMFGTSVLTCPKIQSSLDY-FTQIVHKVFEHSSRLMTFPPRLAQILRLPIWR 282
            ..::.::||.....:||..:.......||... |...:..:|:.:.:||..|..|::.....:|:
Human   190 PSIFHYTIEASNLALFGERLGLVGHSPSSASLNFLHALEVMFKSTVQLMFMPRSLSRWTSPKVWK 254

  Fly   283 D-FEANVDEVLREGAAIIDHCIRVQEDQRRPHDEALYHRLQA-----------ADVPGDMIKRIF 335
            : ||| .|.:.:.|    |:||      ::.:.|..:.|.|.           |::..|.||...
Human   255 EHFEA-WDCIFQYG----DNCI------QKIYQELAFSRPQQYTSIVAELLLNAELSPDAIKANS 308

  Fly   336 VDLVIAAGDTTAFSSQWALFALSKEPRLQQRLAKE-------------RATNDSRLMHGLIKESL 387
            ::|...:.|||.|.....||.|::.|.:||.|.:|             :||.:..|:...:||:|
Human   309 MELTAGSVDTTVFPLLMTLFELARNPNVQQALRQESLAAAASISEHPQKATTELPLLRAALKETL 373

  Fly   388 RLYPVAPFIGRYLPQDAQLGGHFIEKDTMVLLSLYTAGRDPSHFEQPERVLPERWCIGETEQVHK 452
            |||||..|:.|....|..|..:.|...|:|.:.||:.||:|:.|.:|||..|:||.  :.....:
Human   374 RLYPVGLFLERVASSDLVLQNYHIPAGTLVRVFLYSLGRNPALFPRPERYNPQRWL--DIRGSGR 436

  Fly   453 SHGSLPFAIGQRSCIGRRVALKQLHSLLGRCAAQFEMSCLNEMPVDSVLRMVTVPDRTLRLALR 516
            :...:||..|.|.|:|||:|..::..||.......::..|.:..:..|...:..|.....|..|
Human   437 NFYHVPFGFGMRQCLGRRLAEAEMLLLLHHVLKHLQVETLTQEDIKMVYSFILRPSMFPLLTFR 500

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
sad	NP_650123.1	p450	63..497	CDD:299894	122/463 (26%)
CYP11B1	NP_000488.3	p450	42..454	CDD:365848	118/439 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0159
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D185685at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.820