DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment sad and Cyp11b2

DIOPT Version :9

Sequence 1:	NP_650123.1	Gene:	sad / 44858	FlyBaseID:	FBgn0003312	Length:	520	Species:	Drosophila melanogaster
Sequence 2:	NP_034121.4	Gene:	Cyp11b2 / 13072	MGIID:	88584	Length:	500	Species:	Mus musculus

Alignment Length:	503	Identity:	136/503 - (27%)
Similarity:	227/503 - (45%)	Gaps:	58/503 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly    37 PPPLQRFPATELPPAVAAKYVPIPRVKGLPVVGTLVDLIAAGGATHLHKYIDARHKQYGPIFRER 101
            |..||.|.|  :|.....|::            .::.::...|..:||..:....::.|||||..
Mouse    32 PKTLQPFEA--IPQYSRNKWL------------KMIQILREQGQENLHLEMHQVFRELGPIFRHS 82

  Fly   102 LGGTQDAVFVSSANLMRGVFQHEGQYPQHPLPDAWTLYNQQHACQRGLFFMEGAEWLHNRRILNR 166
            :|.|| .|.|........:.|.|...|:....:.|..:.:....:||:|.:.|.||..||..|||
Mouse    83 VGKTQ-IVSVMLPEDAEKLHQVESMLPRRMHLEPWVAHRELRGLRRGVFLLNGPEWRLNRLRLNR 146

  Fly   167 LLLNGNLNWMDV-HIESCTRRMVDQWKRRTAEAAAIPLAESGEIRSYELPLLEQQLYRWSIEVLC 230
            .:|:.......| .::...|..::..|.:..:.|...|...          ::|.|:.::||...
Mouse   147 NVLSPKAVQKFVPMVDMVARDFLETLKEKVLQNARGSLTMD----------VQQSLFNYTIEASN 201

  Fly   231 CIMFG--TSVLTCPKIQSSLDYFTQIVHKVFEHSSRLMTFPPRLAQILRLPIWRD-FEANVDEVL 292
            ..:||  ..:|.......||. |...:|.:|:.:|:|:..|..|.:.....:|:: |:|  .:|:
Mouse   202 FALFGERLGLLGHDLSPGSLK-FIHALHSMFKSTSQLLFLPKSLTRWTSTRVWKEHFDA--WDVI 263

  Fly   293 REGAAIIDHCI-RVQEDQR----RPHDEALYHRLQAADVPGDMIKRIFVDLVIAAGDTTAFSSQW 352
            .|.|   :.|| :|.::.|    :.:...:...:....:|.|.||...::|...:.||||.....
Mouse   264 SEYA---NRCIWKVHQELRLGSSQTYSGIVAELISQGSLPLDAIKANSMELTAGSVDTTAIPLVM 325

  Fly   353 ALFALSKEPRLQQRLAKE-------------RATNDSRLMHGLIKESLRLYPVAPFIGRYLPQDA 404
            .||.|::.|.:|:.|.:|             :|.:|..|:...:||:||||||..|:.|.|..|.
Mouse   326 TLFELARNPDVQKALRQESLAAEASIAANPQKAMSDLPLLRAALKETLRLYPVGGFLERILSSDL 390

  Fly   405 QLGGHFIEKDTMVLLSLYTAGRDPSHFEQPERVLPERWCIGETEQVHKSHGSLPFAIGQRSCIGR 469
            .|..:.:...|:|||.||:.||:|:.|.:|||.:|:||.     :..:|...|.|..|.|.|:||
Mouse   391 VLQNYHVPAGTLVLLYLYSMGRNPAVFPRPERYMPQRWL-----ERKRSFQHLAFGFGVRQCLGR 450

  Fly   470 RVALKQLHSLLGRCAAQFEMSCLNEMPVDSVLRMVTVPDRTLRLALRP 517
            |:|..::..||......|::..|.:..|....|.|.:|..:..|..||
Mouse   451 RLAEVEMMLLLHHILKTFQVETLRQEDVQMAYRFVLMPSSSPVLTFRP 498

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
sad	NP_650123.1	p450	63..497	CDD:299894	122/455 (27%)
Cyp11b2	NP_034121.4	p450	42..496	CDD:365848	129/487 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S5034
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D185685at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.870