DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment sad and Cyp11a1

DIOPT Version :9

Sequence 1:	NP_650123.1	Gene:	sad / 44858	FlyBaseID:	FBgn0003312	Length:	520	Species:	Drosophila melanogaster
Sequence 2:	NP_062753.3	Gene:	Cyp11a1 / 13070	MGIID:	88582	Length:	526	Species:	Mus musculus

Alignment Length:	463	Identity:	113/463 - (24%)
Similarity:	200/463 - (43%)	Gaps:	44/463 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly    79 GATHLHKYIDARHKQYGPIFRERLGGTQDAVFVSSANLMRGVFQHEGQYPQHPLPDAWTLYNQQH 143
            |...:|.:.....::||||:||:| ||.::|::........:|..||..|:..|...|..|:|.:
Mouse    67 GTQKIHYHQMQSFQKYGPIYREKL-GTLESVYIVDPKDASILFSCEGPNPERFLVPPWVAYHQYY 130

  Fly   144 ACQRGLFFMEGAEWLHNRRILNR-LLLNGNLNWMDVHIESCTRRMVDQWKRRTAEAAAIPLAESG 207
            ....|:.|.....|..:|.:||: ::..|.:......:|...:..:....||      |....||
Mouse   131 QRPIGVLFKSSDAWKKDRIVLNQEVMAPGAIKNFVPLLEGVAQDFIKVLHRR------IKQQNSG 189

  Fly   208 EIRSYELPLLEQQLYRWSIEVLCCIMFGTSV-----LTCPKIQSSLDYFTQIVHKVFEHSSRLMT 267
            ....    ::...|:|:|.|.:..::||..:     :..|:.|.    |...|:::|..|..::.
Mouse   190 NFSG----VISDDLFRFSFESISSVIFGERMGMLEEIVDPEAQR----FINAVYQMFHTSVPMLN 246

  Fly   268 FPPRLAQILRLPIWRDFEANVDEVLREGAAIIDHCIRVQEDQRRPHD-----EALYHRLQAADVP 327
            .||...::||...|:|..|..|.:..:..   ::......|.|:..|     ..||..|....:|
Mouse   247 LPPDFFRLLRTKTWKDHAAAWDVIFNKAD---EYTQNFYWDLRQKRDFSQYPGVLYSLLGGNKLP 308

  Fly   328 GDMIKRIFVDLVIAAGDTTAFSSQWALFALSKEPRLQQRL------AKERATNDSR-------LM 379
            ...|:....:::....|||:.:.||.|:.::...::|:.|      |:.:|..|..       |:
Mouse   309 FKNIQANITEMLAGGVDTTSMTLQWNLYEMAHNLKVQEMLRAEVLAARRQAQGDMAKMVQLVPLL 373

  Fly   380 HGLIKESLRLYPVAPFIGRYLPQDAQLGGHFIEKDTMVLLSLYTAGRDPSHFEQPERVLPERWCI 444
            ...|||:|||:|::..:.||...|..|..:.|...|:|.::.:..||||..|..|.:..|.||..
Mouse   374 KASIKETLRLHPISVTLQRYTVNDLVLRNYKIPAKTLVQVASFAMGRDPGFFPNPNKFDPTRWLE 438

  Fly   445 GETEQVHKSHGSLPFAIGQRSCIGRRVALKQLHSLLGRCAAQFEMSCLNEMPVDSVLRMVTVPDR 509
            ......|..:  |.|..|.|.|:|||:|..::..||......|.:...|...|.:...::.:|:.
Mouse   439 KSQNTTHFRY--LGFGWGVRQCLGRRIAELEMTILLINLLENFRIEVQNLRDVGTKFSLILMPEN 501

  Fly   510 TLRLALRP 517
            .:....:|
Mouse   502 PILFNFQP 509

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
sad	NP_650123.1	p450	63..497	CDD:299894	110/441 (25%)
Cyp11a1	NP_062753.3	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	30..49
Cyp11a1	NP_062753.3	p450	49..507	CDD:278495	112/459 (24%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0159
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D185685at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_110753
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	4.720