DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment sad and Cyp11b1

DIOPT Version :9

Sequence 1:	NP_650123.1	Gene:	sad / 44858	FlyBaseID:	FBgn0003312	Length:	520	Species:	Drosophila melanogaster
Sequence 2:	NP_001028401.2	Gene:	Cyp11b1 / 110115	MGIID:	88583	Length:	501	Species:	Mus musculus

Alignment Length:	501	Identity:	127/501 - (25%)
Similarity:	229/501 - (45%)	Gaps:	55/501 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly    37 PPPLQRFPATELPPAVAAKYVPIPRVKGLPVVGTLVDLIAAGGATHLHKYIDARHKQYGPIFRER 101
            |..||.|.|  :|.....|::            .::.::...|..:||..:....::.|||||..
Mouse    34 PKTLQPFEA--IPQYSRNKWL------------KMIQILREQGQENLHLEMHQVFRELGPIFRHS 84

  Fly   102 LGGTQDAVFVSSANLMRGVFQHEGQYP-QHPLPDAWTLYNQQHACQRGLFFMEGAEWLHNRRILN 165
            :|.|| .|||:....:..::|.|..:| :.|| ::|.::.:.....||:|.:.|.||..||..||
Mouse    85 VGKTQ-IVFVTLPEDVEKLYQVESTHPCRMPL-ESWIVHRELRGLGRGVFLLNGPEWYFNRLQLN 147

  Fly   166 RLLLNGNLNWMDVH-IESCTRRMVDQWKRRTAEAAAIPLAESGEIRSYELPLLEQQLYRWSIEVL 229
            ..:|:.......|. ::...|..||..|::..|:..         .|:.:. .:..::.::||..
Mouse   148 PNVLSPKAVQKFVPLVDGIARDFVDNLKKKMLESVH---------GSFSMD-FQSSVFNYTIEAS 202

  Fly   230 CCIMFGTSV-LTCPKIQSSLDYFTQIVHKVFEHSSRLMTFPPRLAQILRLPIWRDFEANVDEVLR 293
            ..::||..: |....:......|...:|.:|:.:::|:..|..|.:.....:|::...:.|.:
Mouse   203 HFVLFGERLGLIGRDLSPDSLKFLHTLHSMFKTTTQLLYLPRSLTRWTSTRVWKENLESWDFI-- 265

  Fly   294 EGAAIIDHCIR-VQED--QRRPHDEALYHRLQA-ADVPGDMIKRIFVDLVIAAGDTTAFSSQWAL 354
              :..:..||: |..:  :.||...::...|.| ..:..|.|:...::|:..:.|||:.......
Mouse   266 --SEYVTKCIKNVYRELAEGRPQSWSVTAELVAERTLSMDAIQANSMELIAGSTDTTSTPLVMTF 328

  Fly   355 FALSKEPRLQQRLAKE-------------RATNDSRLMHGLIKESLRLYPVAPFIGRYLPQDAQL 406
            |.|::.|.:||.|.:|             :|.:|..|:...:||:||||||..|:.|.|..|..|
Mouse   329 FELARNPDVQQALRQESLAAEASIAANPQKAMSDLPLLRAALKETLRLYPVGTFLERILSSDLVL 393

  Fly   407 GGHFIEKDTMVLLSLYTAGRDPSHFEQPERVLPERWCIGETEQVHKSHGSLPFAIGQRSCIGRRV 471
            ..:.:...|::.::||:.||:|:.|.:|||.:|:||.     :..:|...|.|..|.|.|:|||:
Mouse   394 QNYHVPAGTVLNVNLYSMGRNPAVFPRPERYMPQRWL-----ERKRSFKHLAFGFGVRQCLGRRL 453

  Fly   472 ALKQLHSLLGRCAAQFEMSCLNEMPVDSVLRMVTVPDRTLRLALRP 517
            |..::..||......|.:....:..|....|.|.:|..:..|..||
Mouse   454 AEAEMMLLLHHVLKSFHVETQEKEDVRMAYRFVLMPSSSPLLTFRP 499

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
sad	NP_650123.1	p450	63..497	CDD:299894	113/453 (25%)
Cyp11b1	NP_001028401.2	p450	44..497	CDD:278495	120/485 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0159
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D185685at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.820