DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment rib and CG8924

DIOPT Version :9

Sequence 1:	NP_001261085.1	Gene:	rib / 44855	FlyBaseID:	FBgn0003254	Length:	680	Species:	Drosophila melanogaster
Sequence 2:	NP_573091.1	Gene:	CG8924 / 32557	FlyBaseID:	FBgn0030710	Length:	514	Species:	Drosophila melanogaster

Alignment Length:	582	Identity:	140/582 - (24%)
Similarity:	211/582 - (36%)	Gaps:	137/582 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MGGPTAPVASSGEVGQTYCLRWNNHQTNLVQILHALHEVGSYVDCSLVVDDEQFQAHRVVLAANS 65
            |.|.|          |.:|:|||:|..::......|.....:||.:|..:.:|...||:||||.|
  Fly     1 MSGAT----------QEFCVRWNSHLGSIGAAFPQLLAGQRFVDVTLACEGQQVHCHRLVLAACS 55

  Fly    66 PYFQHILKDVPQDHCSIILP-GVKGFEIAALLQYMYTGETTVTKSQEPEILRTAKELQVKGLYDN 129
            .||:.||.:.|..|..|||| .:|.:||.||:.:||.||..||::...::||.|::||::|||.:
  Fly    56 TYFEAILAEHPCKHPVIILPREIKLWEIQALVDFMYKGEVNVTQAGLGQLLRCAEQLQIRGLYGS 120

  Fly   130 LMKFNHASVTPTSSSGAGGAKPQNGSASNH--SSSVISTSTHISPSAAISSSCSPPPPPQFGYQP 192
            ....|:..:...|...|.........:..|  |:.....:|:.:.|..:::|.:||.|... .||
  Fly   121 EAPINYKKLQQASLEAAKDPAATTARSFKHVDSAETDDAATNSTTSTTMTTSSAPPLPVNH-QQP 184

  Fly   193 ---------GYSHYPQQQPMSASQIPA--GEAPLTPTQAT------PHSAASGAGEAGGQWPLTP 240
                     ......|||.....|.|.  |.....|::||      .||.|....::|.:.|..
  Fly   185 TVLKRQNPDARQQQQQQQQQQVQQRPQINGSNAQQPSKATSTNVLGSHSNAPTEDDSGDEVPNN- 248

  Fly   241 SAAAAMLNSVYESAADMNPLKRKKLSAISSMLLSGNRDTPI------LRNVLAQANPADSSQPGP 299
                  .|:..|...|.|         ||:..:....:..:      ::..|.|....||:....
  Fly   249 ------WNAYGEQFDDCN---------ISAQAVDNKMNVHLSLQQARMQMQLQQQQYLDSNVEDD 298

  Fly   300 MNANGEKTPTHPHQN-----TQLPAGLGVSGGERNHSFNGSDYGGDKEPLSPYTDRSFEEETGQS 359
            .|    ....|...|     |.:|.|.|:|                   ||..||  .:.....|
  Fly   299 HN----YVAAHDENNDSSFATGVPCGSGLS-------------------LSLDTD--LDTSANTS 338

  Fly   360 GGKKPE----WKRYKQYTR--ADMMCAIQAVREGMSALQASRKYGLPSRTLYDKVRKLNITTGRG 418
            ||....    :..||:..|  |.:..|.:.|.:|.:....|..:.:|..|:...:.:..|
  Fly   339 GGLSHSSIDGYTSYKRVRRSEASLAQAAKCVSKGETFQTVSNMFNIPVSTIRFYMARKGI----- 398

  Fly   419 THRTPKRSPPGAESSQGFSYSAAAAAAAHNYGHGHGHHSEV---KRDQKVDHVPAHHGMPPTIPP 480
               .|||                      ..|.|..|...:   ....|:..|||....||..|.
  Fly   399 ---LPKR----------------------KRGRGASHAGNIIITTNSGKLSTVPASITHPPAHPH 438

  Fly   481 SAAALLDHAFLQQALENRGGDMAGREALH-----AMALAAAAHAAANRLSSSPAEMDQRSNG 537
            .....|.|...||         ...::||     |....:.:.|.|...|.||: .|..:.|
  Fly   439 IHTNPLPHTQSQQ---------MSMDSLHLKAGIANTSGSNSPATATATSMSPS-FDMATTG 490

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
rib	NP_001261085.1	BTB	33..133	CDD:279045	41/100 (41%)
		BTB	44..133	CDD:197585	39/89 (44%)
		HTH_psq	373..417	CDD:283007	9/45 (20%)
CG8924	NP_573091.1	BTB	25..117	CDD:279045	38/91 (42%)
		BTB	34..117	CDD:197585	36/82 (44%)
		MerR	378..407	CDD:278788	8/58 (14%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	59	1.000	Domainoid score	I10615
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1229475at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm40394
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR23110
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	5	5.020