DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment rib and Btbd18

DIOPT Version :9

Sequence 1:	NP_001261085.1	Gene:	rib / 44855	FlyBaseID:	FBgn0003254	Length:	680	Species:	Drosophila melanogaster
Sequence 2:	XP_002729248.1	Gene:	Btbd18 / 100363270	RGDID:	2323370	Length:	724	Species:	Rattus norvegicus

Alignment Length:	718	Identity:	150/718 - (20%)
Similarity:	251/718 - (34%)	Gaps:	187/718 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly    33 LHALHEVGSYVDCSLVVDDEQFQAHRVVLAANSPYF-QHILKDVPQDHCSIILP--GVKGFEIAA 94
            ||...:.|.:.|..|..:.|...||..:|:|.||:| :.:.::.|.....::|.  |:|...:..
  Rat    24 LHHQQQSGVFCDALLQAEGEAVPAHCCILSACSPFFTERLERERPVQGRKVVLELGGLKIQTLRK 88

  Fly    95 LLQYMYTGETTVTKSQEPEILRTAKELQVKGLYDNLMKFNHASVTPTSSSGAGG--AKPQNGSAS 157
            |:.::||.|..|::.:..::|..|::|:|..|....::              ||  .|...|...
  Rat    89 LVDFLYTSEMEVSQEEAQDVLSAARQLRVSELETLQLE--------------GGKLVKAPQGRRL 139

  Fly   158 NHSSSVISTSTHISPSAAISSSCSPPPPPQFGYQPGYSHYPQQQPMSASQIPAGEAPLTPTQATP 222
            |.                   .|..|              |...|:||..:.....|.||...|.
  Rat   140 NR-------------------ECLQP--------------PSAAPISARVVVPRSRPRTPLPVTQ 171

  Fly   223 HSAASGA------GEAGGQWPLT--PSAAAAMLNSVYESAADMNPLKRKK---LSAISSMLLSGN 276
            ..:..||      ||..|....:  |:|         ::.:|...||:|.   |:...|...|..
  Rat   172 TPSPLGAVKLKSLGEEEGAHKKSNLPNA---------DNLSDTLLLKKKARVCLTQERSSSPSSQ 227

  Fly   277 RDTPILRNVLAQANPADSSQPG----------PMNANGEKTPTHPHQNTQLPAGLGVSGGE---- 327
            |:.| ..|   ::||..::.|.          |......::...||..|..|:.: :||..
  Rat   228 REGP-KEN---KSNPGSTALPSLYPSVDEQLLPRKIRLSRSKPSPHVYTSKPSSM-LSGPSSMPT 287

  Fly   328 -------RNHSFNGSDYGGDKE-PLSPYTDRSFEE--ETGQSGGKK---PEWKRYKQYTRADMMC 379
                   |..:.:.:..|.||: |....|.:|..:  :.|::||||   ||       :||.
  Rat   288 APGRRLWRQRTVSEATQGVDKQKPGEVSTLQSTPDPPDVGKTGGKKQPSPE-------SRAP--- 342

  Fly   380 AIQAVREGMSALQASRKYGLPSRTLYDKVRKLNITTGRGTHRTPK-------RSPPGAESSQGFS 437
            |..:|.||.......||  :.:.|.::.|::..|   |.|..:|:       ..|||...|   |
  Rat   343 ASNSVEEGQVGRVKLRK--IVNGTCWEVVQEPPI---RNTQDSPQILESSDADEPPGTLLS---S 399

  Fly   438 YSAAAAAAAHNYGHGHGHHSEVK-----RDQKVDH--VPAHHGMPPTIPPSAAAL---------L 486
            .:.....|.....|....:|.::     .....||  |.:..|..|.:......|         .
  Rat   400 VNEQEIPARIQLCHDSPENSRLQDILLSASHSPDHPVVKSEFGSSPMLTGKEPELNIDCREPYTF 464

  Fly   487 DHAFLQQALE-------NRGGDMAGREALHAMALAAAAHAAANRLSSSPAEMDQRSNGHGMRSP- 543
            |...|.|..|       :........|.|..|...:........|.|..||        |.|:|
  Rat   465 DTTLLSQPCEAEQYRITSAAATSELEEILDFMLCGSDVEPPVGSLESPGAE--------GCRTPS 521

  Fly   544 ---SPQGRHYPHEQE--AMDLEMEKHEQNIIKRERDQDEREDADD-----EEDHEQEHVEDLS-- 596
               |..|:::...:|  ..|:|:...:...:::|...:.:|..:.     ......|.:|.||
  Rat   522 YHLSETGKNWIEGEEWCLPDMELWPRDLTGLEKEPVGENKEPVEPFSPLVMRSENTESIEPLSPL 586

  Fly   597 -----LARKE-------RPPSPY-SPQPTEAGAGVIMHASSASANGKDHVDY-PSSPQFVPIGLK 647
                 ::|:|       .|.... |.||.:.....::|..|:..:.:.:.|. |..|.:...||:
  Rat   587 VMPSEVSREELSLRGSWTPDLEITSSQPLDGQGEKLIHLDSSDPSQRSYSDLSPPCPNWADTGLE 651

  Fly   648 REL 650
            ..|
  Rat   652 VSL 654

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
rib	NP_001261085.1	BTB	33..133	CDD:279045	27/102 (26%)
		BTB	44..133	CDD:197585	24/91 (26%)
		HTH_psq	373..417	CDD:283007	11/43 (26%)
Btbd18	XP_002729248.1	BTB	24..123	CDD:279045	27/98 (28%)
Btbd18	XP_002729248.1	BTB	35..123	CDD:197585	24/87 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	59	1.000	Domainoid score	I10373
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.910