DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment pnr and gata4

DIOPT Version :9

Sequence 1:	NP_476685.1	Gene:	pnr / 44849	FlyBaseID:	FBgn0003117	Length:	540	Species:	Drosophila melanogaster
Sequence 2:	NP_001016949.1	Gene:	gata4 / 549703	XenbaseID:	XB-GENE-487458	Length:	394	Species:	Xenopus tropicalis

Alignment Length:	447	Identity:	163/447 - (36%)
Similarity:	213/447 - (47%)	Gaps:	133/447 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly    27 YQNVTLSAASA------------STSASASATHVAAVKMYHSSAVAAYTDLAAAGSAASAGVGVG 79
            ||::.::|...            |.:|:.|..:|...::  ||.:.:...|..:||:..   |..
Frog     2 YQSIAMAANHGPPAYEGAGGYMHSATAATSPVYVPTTRV--SSMIPSLPYLQTSGSSQQ---GSP 61

  Fly    80 VSGYHQQA-------------------------VNAPVYVPSNRQYNHVAAHFGSAAAQNAWTTE 119
            |||::..|                         .:.|:...|||:     ..:.|..|.:|...|
Frog    62 VSGHNMWAQAGAEPSAYNPGTSHPPVSPRFTFSSSPPISAASNRE-----VPYSSPLAISANGRE 121

  Fly   120 GFGSA-HAQFYSPNAAVM---MG-SWRSAYDPSGFQRSSPYESAM------------------DF 161
            .:|.| .|.:.||..|.|   || :|          .:||::|:|                  :|
Frog   122 QYGRALGATYSSPYPAYMSPDMGATW----------TASPFDSSMLHNLQNRAGPAASRHPNIEF 176

  Fly   162 --QFGEGRECVNCGAISTPLWRRDGTGHYLCNACGLYHKMNGMNRPLIKPSKRLVSATATRRMGL 224
              .|.||||||||||:||||||||||||||||||||||||||:|||||||.:||   :|:||:||
Frog   177 FDDFSEGRECVNCGAMSTPLWRRDGTGHYLCNACGLYHKMNGINRPLIKPQRRL---SASRRVGL 238

  Fly   225 CCTNCGTRTTTLWRRNNDGEPVCNACGLYYKLHGVNRPLAMRKDGIQTRKRKPKK-------TGS 282
            .|.||.|.||||||||.:|||||||||||.|||||.|||||:|:||||||||||.       ||.
Frog   239 SCANCHTTTTTLWRRNAEGEPVCNACGLYMKLHGVPRPLAMKKEGIQTRKRKPKNLSKSKTPTGQ 303

  Fly   283 GSAVG-AGTGSGTGSTLEAIKECKEEHDLKPSLSLERHSLSKLHTDMKSGTSSSSTLMGHHSAQQ 346
            .|:.. ..:.|.|.|..|.::..|.|..|.|...         |:...|..|..||...|.|:.
Frog   304 NSSDSLTPSTSSTNSAGEEMRPIKIEPGLSPPYG---------HSSSLSQASVLSTTTSHGSSS- 358

  Fly   347 QQQQQQQQQQQQQQQQQQSAHQQCFPLYGQTTTQQQHQQHGHSMTSSSGQAHLSARH 403
                                    :|:.....:.|.|    ||..::|.||  |::|
Frog   359 ------------------------YPMSSLKLSPQNH----HSTINTSPQA--SSKH 385

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
pnr	NP_476685.1	ZnF_GATA	164..212	CDD:214648	43/47 (91%)
		ZnF_GATA	168..212	CDD:238123	40/43 (93%)
		ZnF_GATA	223..270	CDD:214648	36/46 (78%)
		ZnF_GATA	226..276	CDD:238123	40/49 (82%)
gata4	NP_001016949.1	GATA-N	1..174	CDD:283099	39/191 (20%)
		ZnF_GATA	181..228	CDD:214648	43/46 (93%)
		ZnF_GATA	185..235	CDD:238123	43/52 (83%)
		ZnF_GATA	237..284	CDD:214648	36/46 (78%)
		ZnF_GATA	239..290	CDD:238123	40/50 (80%)
		Peptidase_S64	293..>387	CDD:285411	28/133 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	81	1.000	Domainoid score	I8385
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	223	1.000	Inparanoid score	I3430
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000130
OrthoInspector	1	1.000	-	-		otm47735
Panther	1	1.100	-	-	LDO	PTHR10071
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1745
SonicParanoid	1	1.000	-	-		X1091
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	8	8.090