DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment pnr and GATA3

DIOPT Version :9

Sequence 1:	NP_476685.1	Gene:	pnr / 44849	FlyBaseID:	FBgn0003117	Length:	540	Species:	Drosophila melanogaster
Sequence 2:	NP_001002295.1	Gene:	GATA3 / 2625	HGNCID:	4172	Length:	444	Species:	Homo sapiens

Alignment Length:	366	Identity:	134/366 - (36%)
Similarity:	162/366 - (44%)	Gaps:	123/366 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly    34 AASASTSASASATHVAAVKMYHSSAVAAYTDLAAAGSAASA------------------------ 74
            |:|:|.|...::.|:..........|:....|:..|||.||
Human   136 ASSSSLSGGHASPHLFTFPPTPPKDVSPDPSLSTPGSAGSARQDEKECLKYQVPLPDSMKLESSH 200

  Fly    75 ------GVGVGVSGYHQQAVNAPVYVPSNRQYNHVAAHFGSAAAQNAWTTEGFGSAHAQFYS--- 130
                  .:|...|..|......|.|||.                                ||
Human   201 SRGSMTALGGASSSTHHPITTYPPYVPE--------------------------------YSSGL 233

  Fly   131 -PNAAVMMGSWRSAYDPSGFQ-RSSPYESAMDFQFGEGRECVNCGAISTPLWRRDGTGHYLCNAC 193
             |.::::.||      |:||. :|.|...:..    ||||||||||.||||||||||||||||||
Human   234 FPPSSLLGGS------PTGFGCKSRPKARSST----EGRECVNCGATSTPLWRRDGTGHYLCNAC 288

  Fly   194 GLYHKMNGMNRPLIKPSKRLVSATATRRMGLCCTNCGTRTTTLWRRNNDGEPVCNACGLYYKLHG 258
            ||||||||.|||||||.:||   :|.||.|..|.||.|.||||||||.:|:|||||||||||||.
Human   289 GLYHKMNGQNRPLIKPKRRL---SAARRAGTSCANCQTTTTTLWRRNANGDPVCNACGLYYKLHN 350

  Fly   259 VNRPLAMRKDGIQTRKRKPKKTGSGSAVGAGTGSGTGSTLEAIKECKEEHD----------LKPS 313
            :||||.|:|:|||||.||.....                    |:||:.||          ..|:
Human   351 INRPLTMKKEGIQTRNRKMSSKS--------------------KKCKKVHDSLEDFPKNSSFNPA 395

  Fly   314 LSLERHSLSKLHTDMKSGTS------------SSSTLMGHH 342
             :|.||..|..|....|.:|            ||.:...||
Human   396 -ALSRHMSSLSHISPFSHSSHMLTTPTPMHPPSSLSFGPHH 435

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
pnr	NP_476685.1	ZnF_GATA	164..212	CDD:214648	43/47 (91%)
		ZnF_GATA	168..212	CDD:238123	40/43 (93%)
		ZnF_GATA	223..270	CDD:214648	33/46 (72%)
		ZnF_GATA	226..276	CDD:238123	37/49 (76%)
GATA3	NP_001002295.1	Interaction with TBX21. /evidence=ECO:0000250\|UniProtKB:P23772	1..258		29/159 (18%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..29
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	128..180		12/43 (28%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	194..216		2/21 (10%)
		ZnF_GATA	260..307	CDD:214648	43/46 (93%)
		ZnF_GATA	263..313	CDD:238123	43/52 (83%)
		Flexible linker	289..317		21/30 (70%)
		ZnF_GATA	313..362	CDD:214648	34/48 (71%)
		ZnF_GATA	317..367	CDD:238123	37/49 (76%)
		YxKxHxxxRP. /evidence=ECO:0000250	345..354		6/8 (75%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	362..390		11/47 (23%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	415..444		4/21 (19%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5641
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000130
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1745
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.840