DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment pnr and Gata1

DIOPT Version :9

Sequence 1:	NP_476685.1	Gene:	pnr / 44849	FlyBaseID:	FBgn0003117	Length:	540	Species:	Drosophila melanogaster
Sequence 2:	NP_036896.1	Gene:	Gata1 / 25172	RGDID:	2663	Length:	413	Species:	Rattus norvegicus

Alignment Length:	353	Identity:	140/353 - (39%)
Similarity:	170/353 - (48%)	Gaps:	69/353 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 STSDQQSTRDYPHFSGDYQNVTLSAASASTSASASATHVAAVKMY-------HSSAVAAYTDL-- 65
            ||||...     .||...:  :|..||:|||.:|:.....|:..|       ||.....|..|
  Rat    26 STSDSAG-----FFSSGPE--SLDTASSSTSPNAATAAATALAYYREAEAYRHSPVFQVYPLLNS 83

  Fly    66 --AAAGSAASAGVGVG---------VSGYHQQAVNAPVYVPSNRQYNHV------------AAHF 107
              ...||:..|.....         |...|:.|.:..:..|..:..|..            ....
  Rat    84 MEGIPGSSPYASWAYSKTALYPASTVCPSHEDAPSQTLEDPDGKNNNTFLETLKTERLSPDLLTL 148

  Fly   108 GSAAAQN-AWTTEGFGSAH--AQFYSPNAAVMMGSWRSAYDPSGFQRSSPYESAMDFQFGEGREC 169
            |:|...: ..|:..:|.|.  :.|:||..:.:..   :||....|..|.|....      |.|||
  Rat   149 GTALPTSLPVTSSAYGGADFPSPFFSPTGSPLSS---AAYSSPKFHGSLPLAPC------EAREC 204

  Fly   170 VNCGAISTPLWRRDGTGHYLCNACGLYHKMNGMNRPLIKPSKRLVSATATRRMGLCCTNCGTRTT 234
            |||||.:|||||||.|||||||||||||||||.|||||:|.||::   .::|.|..||||.|.||
  Rat   205 VNCGATATPLWRRDRTGHYLCNACGLYHKMNGQNRPLIRPKKRMI---VSKRAGTQCTNCQTTTT 266

  Fly   235 TLWRRNNDGEPVCNACGLYYKLHGVNRPLAMRKDGIQTRKRK-----PKKTGSGSAVGAGTGSGT 294
            ||||||..|:|||||||||||||.|||||.|||||||||.||     .||.|| |..|||...|.
  Rat   267 TLWRRNASGDPVCNACGLYYKLHQVNRPLTMRKDGIQTRNRKASGKGKKKRGS-SLAGAGAAEGP 330

  Fly   295 GSTLEAIK------ECKEEHDLKPSLSL 316
            ......:.      .|.|   :.|.|:|
  Rat   331 AGGFMVVAGGSSSGNCGE---VAPGLTL 355

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
pnr	NP_476685.1	ZnF_GATA	164..212	CDD:214648	39/47 (83%)
		ZnF_GATA	168..212	CDD:238123	37/43 (86%)
		ZnF_GATA	223..270	CDD:214648	37/46 (80%)
		ZnF_GATA	226..276	CDD:238123	41/49 (84%)
Gata1	NP_036896.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	109..128		4/18 (22%)
		Interaction with MED1 and CCAR1. /evidence=ECO:0000250\|UniProtKB:P15976	200..330		94/133 (71%)
		ZnF_GATA	202..247	CDD:214648	38/44 (86%)
		ZnF_GATA	203..249	CDD:238123	39/45 (87%)
		Required for interaction with ZFPM1. /evidence=ECO:0000250	203..222		15/18 (83%)
		Interaction with CALCOCO1. /evidence=ECO:0000250\|UniProtKB:P15976	249..315		45/68 (66%)
		ZnF_GATA	<268..308	CDD:238123	33/39 (85%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	297..325		17/28 (61%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	391..413
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5641
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000130
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.810