DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment pnr and Gata2

DIOPT Version :9

Sequence 1:	NP_476685.1	Gene:	pnr / 44849	FlyBaseID:	FBgn0003117	Length:	540	Species:	Drosophila melanogaster
Sequence 2:	NP_001342182.1	Gene:	Gata2 / 14461	MGIID:	95662	Length:	480	Species:	Mus musculus

Alignment Length:	321	Identity:	137/321 - (42%)
Similarity:	165/321 - (51%)	Gaps:	51/321 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    33 SAASASTSASASATHVAAVKMYHSSAVAAYTDLAAAGSAASAGVGVGVS-GYHQQAVNAPVYVPS 96
            |.||.:.:|:.|.:|:..........|:.......|.|.||:..|..|: |..:..|...|.:..
Mouse   155 SVASLTPTAAHSGSHLFGFPPTPPKEVSPDPSTTGAASPASSSAGGSVARGEDKDGVKYQVSLSE 219

  Fly    97 NRQYNHVAAHFGSAAAQNAWTTEGFGSA-HAQF-----YSPNAAVMMGSWRSAYDPSGF-----Q 150
            :.:..      |.:..:....|.|...| |...     |.|.||...||  |.:.|.||     .
Mouse   220 SMKME------GGSPLRPGLATMGTQPATHHPIPTYPSYVPAAAHDYGS--SLFHPGGFLGGPAS 276

  Fly   151 RSSPYESAMDFQFGEGRECVNCGAISTPLWRRDGTGHYLCNACGLYHKMNGMNRPLIKPSKRLVS 215
            ..:|.:.:......||||||||||.:|||||||||||||||||||||||||.|||||||.:||
Mouse   277 SFTPKQRSKARSCSEGRECVNCGATATPLWRRDGTGHYLCNACGLYHKMNGQNRPLIKPKRRL-- 339

  Fly   216 ATATRRMGLCCTNCGTRTTTLWRRNNDGEPVCNACGLYYKLHGVNRPLAMRKDGIQTRKRKPKKT 280
             :|.||.|.||.||.|.||||||||.:|:|||||||||||||.|||||.|:|:|||||.||....
Mouse   340 -SAARRAGTCCANCQTTTTTLWRRNANGDPVCNACGLYYKLHNVNRPLTMKKEGIQTRNRKMSSK 403

  Fly   281 GSGSAVGAGTGSGTGSTLEAIKECKEEHDLKPSLSLERHSLSKLHTDMKSGTSSSSTLMGH 341
            ...|..||              ||.||             |||...: ||...|::.|.||
Mouse   404 SKKSKKGA--------------ECFEE-------------LSKCMQE-KSPPFSAAALAGH 436

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
pnr	NP_476685.1	ZnF_GATA	164..212	CDD:214648	42/47 (89%)
		ZnF_GATA	168..212	CDD:238123	39/43 (91%)
		ZnF_GATA	223..270	CDD:214648	35/46 (76%)
		ZnF_GATA	226..276	CDD:238123	38/49 (78%)
Gata2	NP_001342182.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	166..208		10/41 (24%)
		ZnF_GATA	294..344	CDD:238123	42/52 (81%)
		ZnF_GATA	349..398	CDD:238123	38/48 (79%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	457..480
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5641
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000130
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1745
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.840